GlpBio

FXR & LXR

FXR (farnesoid X receptor) is a nuclear receptor that binds to hormone response elements on DNA, regulating the expression of certain genes when it is activated.

LXR (liver X receptor) is a member of the nuclear receptor family of transcription factors and is an important regulator of cholesterol, fatty acid, and glucose homeostasis.

FXR & LXR 相关产品(77)

  • GC10760 structure
    GC10760XL335
    CAS: 629664-81-9
    纯度: >99.50%

    A potent and selective FXR agonist

  • GC10975 structure
    GC10975GW4064
    CAS: 278779-30-9
    纯度: >99.50%

    GW4064作为合成的FXR激动剂，用于治疗胆汁淤积性肝病、代谢综合征和酒精性肝病。

  • GC17985 structure
    GC17985Chenodeoxycholic Acid
    CAS: 474-25-9
    纯度: >98.00%

    A primary bile acid

  • GC19421 structure
    GC19421LY2562175
    CAS: 1103500-20-4
    纯度: >98.00%

    An FXR agonist

  • GC10596 structure
    GC10596T0901317
    CAS: 293754-55-9
    纯度: >99.50%

    T0901317是一种口服活性高选择性LXR激动剂，对LXRα的EC 50 为15nM，并能激活异生物质受体孕烷X受体(PXR)，EC 50 为23nM。

  • GC10755 structure
    GC10755Fexaramine
    CAS: 574013-66-4
    纯度: >99.00%

    A selective FXR agonist

  • GC11700 structure
    GC1170025(S)-27-hydroxy Cholesterol
    CAS: 56845-83-1

    An endogenous agonist for LXR

  • GC11885 structure
    GC11885Sevelamer HCl
    CAS: 152751-57-0
    纯度: >98.00%

    Sevelamer HCl 是一种磷酸盐结合药物，用于治疗慢性肾病患者的高磷血症；由与环氧氯丙烷交联的聚烯丙胺组成。

  • GC13431 structure
    GC1343124α-methyl Cholesterol
    CAS: 474-62-4
    纯度: >98.00%

    A phytosterol

  • GC13680 structure
    GC13680SR-9243
    CAS: 1613028-81-1
    纯度: >99.50%

    An LXR inverse agonist

  • GC13887 structure
    GC1388725(R)-27-hydroxy Cholesterol
    CAS: 20380-11-4
    纯度: >98.00%

    25(R)-27-hydroxy Cholesterol是肝脏X受体（LXR）α和LXRβ的激动剂，EC 50 值分别为0.085μM和0.071μM。

  • GC13954 structure
    GC13954LXR-623
    CAS: 875787-07-8
    纯度: >99.50%

    An LXR modulator

  • GC14158 structure
    GC14158Obeticholic Acid
    CAS: 459789-99-2
    纯度: >98.00%

    Obeticholic Acid（奥贝胆酸；INT-747；6-ECDCA；6-Ethylchenodeoxycholic acid）是一种有效的，选择性的和口服活性的法尼醇X受体（FXR ）激动剂，EC 50 为99nM。

  • GC14638 structure
    GC14638SR9238
    CAS: 1416153-62-2
    纯度: >99.50%

    A liver-specific inverse agonist of LXR

  • GC14972 structure
    GC1497222(R)-hydroxy Cholesterol
    CAS: 17954-98-2
    纯度: >98.00% / >99.50%

    22(R)-hydroxy Cholesterol是一种肝X受体（LXR）的内源性激动剂，其EC 50 值为325nM。

  • GC16964 structure
    GC16964GW3965
    CAS: 405911-09-3

    An orally-active agonist of LXRα and LXRβ

  • GC17059 structure
    GC17059Acetyl Podocarpic Acid Anhydride
    CAS: 344327-48-6

    An endogenous LXR agonist

  • GC17658 structure
    GC17658Guggulsterone
    CAS: 95975-55-6
    纯度: >99.50%

    Guggulsterone是一种从植物Commiphora wightii的树脂中提取的植物甾醇。Guggulsterone可以抑制多种肿瘤细胞的生长，并通过下调抗凋亡基因产物（IAP1、xIAP、Bfl-1/A1、Bcl-2、cFLIP和survivin）、调节细胞周期蛋白（如Cyclin D1和c-Myc）、激活半胱氨酸蛋白酶、抑制Akt以及激活JNK来诱导细胞凋亡。

  • GC17696 structure
    GC17696GW3965 HCl
    CAS: 405911-17-3
    纯度: >99.50%

    GW3965 HCl是一种选择性的口服活性非甾体激动剂，用于肝X受体（LXR）。

  • GC17827 structure
    GC1782724(R)-hydroxy Cholesterol
    CAS: 27460-26-0
    纯度: >98.00%

    A synthetic enantiomer of a brain-derived oxysterol

  • GC18076 structure
    GC1807624(S)-hydroxy Cholesterol
    CAS: 474-73-7
    纯度: >95.00%

    An agonist of LXR receptors

  • GC18212 structure
    GC18212Cilofexor
    CAS: 1418274-28-8
    纯度: >99.50%

    An FXR ligand

  • GC18270 structure
    GC1827022(S)-hydroxy Cholesterol
    CAS: 22348-64-7
    纯度: >95.00%

    A synthetic oxysterol and LXR modulator

  • GC19363 structure
    GC19363Tropifexor
    CAS: 1383816-29-2
    纯度: >98.00%

    An FXR agonist