DNA Damage/DNA Repair
DNA Damage/DNA Repair(DNA损伤/DNA修复)
- MTH1(4)
- PARP(124)
- ATM/ATR(29)
- DNA Alkylating(25)
- DNA Ligases(3)
- DNA Methyltransferase(32)
- DNA-PK(31)
- HDAC(182)
- Nucleoside Antimetabolite/Analogue(160)
- Telomerase(16)
- Topoisomerase(185)
- tankyrase(5)
- Antifolate(33)
- CDK(271)
- Checkpoint Kinase (Chk)(33)
- CRISPR/Cas9(9)
- Deubiquitinase(76)
- DNA Alkylator/Crosslinker(73)
- DNA/RNA Synthesis(473)
- Eukaryotic Initiation Factor (eIF)(27)
- IRE1(23)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(48)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(1)
- Early 2 Factor (E2F)(1)
DNA Damage/DNA Repair 相关产品(1788)
- GC19566N-Nitrosodiethylamine (950mg/mL)CAS: 55-18-5纯度: >99.00% / >95.00%
N-Nitrosodiethylamine (Diethylnitrosamine) 是一种有效的肝癌致癌二烷基亚硝胺。 N-亚硝基二乙胺主要存在于烟草烟雾、水、切达奶酪、腌制食品、油炸食品和许多酒精饮料中。 N-亚硝基二乙胺负责与 DNA 修复/复制相关的核酶的变化。 N-亚硝基二乙胺在所有动物物种中导致各种肿瘤。主要靶器官为鼻腔、气管、肺、食道和肝脏。
- GC25139Biphenyl-4-sulfonyl chlorideCAS: 1623-93-4
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation.
- GC25372Elimusertib (BAY-1895344) hydrochloride
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM.
- GC25593LY3143921 hydrateCAS: 1627696-53-0
LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor.
- GC26084XL413 (BMS-863233)CAS: 1169562-71-3
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2.
- GC30276Casein Kinase II Inhibitor IVCAS: 863598-09-8纯度: >98.00%
CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC19451 | SBI-0640756 | 1821280-29-8 | >98.50% | |
SBI-0640756 (SBI-756) 是 eIF4G1 的抑制剂，可破坏 eIF4F 复合物。 | ||||
| GC19468 | AZD1390 | 2089288-03-7 | >99.50% | |
AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。 | ||||
| GC19495 | DL-Folinic Acid (calcium salt) | 1492-18-8 | >99.00% | |
A reduced folic acid | ||||
| GC19505 | RK-287107 | 2171386-10-8 | >99.50% | |
A TNKS1/2 inhibitor | ||||
| GC19506 | NITD008 | 1044589-82-3 | >98.00% | |
NITD008 是一种有效的选择性黄病毒抑制剂，可抑制 2 型登革热病毒 (DENV-2)，EC50 为 0.64 μM。 | ||||
| GC19528 | 1,4-Benzoquinone | 106-51-4 | >99.00% | |
A toxic metabolite of benzene | ||||
| GC19542 | GeA-69 | 2143475-98-1 | >99.50% | |
GeA-69 是一种多聚腺苷二磷酸核糖聚合酶 14 (PARP14) 的选择性变构抑制剂，靶向大结构域 2 (MD2)，Kd 值为 2.1 µM。 GeA-69 参与 DNA 损伤修复机制并阻止 PARP14 MD2 募集到激光诱导的 DNA 损伤部位。 | ||||
| GC19566 | N-Nitrosodiethylamine (950mg/mL) | 55-18-5 | >99.00% / >95.00% | |
N-Nitrosodiethylamine (Diethylnitrosamine) 是一种有效的肝癌致癌二烷基亚硝胺。 N-亚硝基二乙胺主要存在于烟草烟雾、水、切达奶酪、腌制食品、油炸食品和许多酒精饮料中。 N-亚硝基二乙胺负责与 DNA 修复/复制相关的核酶的变化。 N-亚硝基二乙胺在所有动物物种中导致各种肿瘤。主要靶器官为鼻腔、气管、肺、食道和肝脏。 | ||||
| GC19622 | HBC (HBC 530) | 156840-13-0 | >98.00% | |
HBC (HBC 530)是一种类GFP的合成染料，最大激发波长为485nm，最大发射波长为530nm。 | ||||
| GC19807 | β-Amanitin | 21150-22-1 | >90.00% | |
A RNA polymerase II and III inhibitor | ||||
| GC19941 | DL-Leucic Acid | 498-36-2 | ≥98% | |
| GC25139 | Biphenyl-4-sulfonyl chloride | 1623-93-4 | - | |
Biphenyl-4-sulfonyl chloride (p-Phenylbenzenesulfonyl, 4-Phenylbenzenesulfonyl, p-Biphenylsulfonyl) is a HDAC inhibitor with synthetic applications in palladium-catalyzed desulfitative C-arylation. | ||||
| GC25372 | Elimusertib (BAY-1895344) hydrochloride | - | - | |
Elimusertib (BAY-1895344) hydrochloride is a potent, highly selective and orally available ATR inhibitor with an IC50 of 7 nM. | ||||
| GC25552 | KT-531 | 2490284-18-7 | - | |
KT-531 (KT531) is a potent, selective HDAC6 inhibitor with IC50 of 8.5 nM, displays 39-fold selectivity over other HDAC isoforms. | ||||
| GC25593 | LY3143921 hydrate | 1627696-53-0 | - | |
LY3143921 hydrate is an orally administered ATP-competitive CDC7 inhibitor. | ||||
| GC25594 | LY3405105 | 2326428-25-3 | - | |
LY3405105 is an orally active CDK7 inhibitor with an IC50 of 92.8 nM. LY3405105 shows potential antineoplastic activity. | ||||
| GC25996 | THZ1 2HCl | 2095433-94-4 | - | |
THZ1 is a covalent CDK7 inhibitor which has the unprecedented ability to target a remote cysteine residue located outside of the canonical kinase domain, providing an unanticipated means of achieving selectivity for CDK7. | ||||
| GC26084 | XL413 (BMS-863233) | 1169562-71-3 | - | |
XL413 (BMS-863233) is a potent and selective cell division cycle 7 homolog (CDC7) kinase inhibitor with IC50 of 3.4 nM, showing 63-, 12- and 35-fold selectivity over CK2, Pim-1 and pMCM2, respectively. Phase 1/2. | ||||
| GC30106 | CHK1 inhibitor | 2097938-64-0 | - | |
CHK1inhibitor是CHK1的抑制剂。 | ||||
| GC30185 | SMN-C3 | 1449597-34-5 | >99.50% | |
SMN-C3是一种可口服的SMN2剪接调节剂，有治疗脊椎肌肉萎缩(SMA)的潜力。 | ||||
| GC30245 | CLK1-IN-1 | 2123491-32-5 | >99.00% | |
CLK1-IN-1是一个有效的、Cdc2-like激酶(CLK1)的选择性抑制剂，其IC50值为2nM。 | ||||
| GC30276 | Casein Kinase II Inhibitor IV | 863598-09-8 | >98.00% | |
CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。 | ||||
| GC30466 | CDK8-IN-3 | 1884500-15-5 | - | |
CDK8-IN-3是CDK8的抑制剂,来自专利WO2016041618A1，化合物实例1.7。 | ||||
| GC30526 | ACY-957 | 1609389-52-7 | >99.50% | |
ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。 | ||||