GlpBio

DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

研究方向

DNA Damage/DNA Repair 相关产品(1788)

  • GC30529 structure
    GC30529GNE-371
    CAS: 1926986-36-8
    纯度: >98.00%

    GNE-371是一种针对人类转录起始因子TFIID亚基1和类转录起始因子TFIID亚基1的第二溴端结构域的高效选择性化学探针，对TAF1(2)的IC50值为10nM。

  • GC30531 structure
    GC305317-Methylguanosine
    CAS: 20244-86-4

    A methylated form of guanosine

  • GC30548 structure
    GC305486-Amino-5-nitropyridin-2-one
    CAS: 211555-30-5

    6-Amino-5-nitropyridin-2-one是一种吡啶碱基，可用作hachimojiDNA的核酸碱基，并与5-aza-7-脱氮鸟嘌呤配对。

  • GC30554 structure
    GC30554Isocytosine
    CAS: 108-53-2
    纯度: >99.50%

    Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.

  • GC30695 structure
    GC30695Phen-DC3
    CAS: 942936-75-6

    Phen-DC3是一个G4特异性配体，可以抑制解旋酶FANCJ和DinG且IC50s值分别为65±6和50±10nM。

  • GC30763 structure
    GC30763Benzenebutyric acid (4-Phenylbutyric acid)
    CAS: 1821-12-1
    纯度: >98.00% / >99.00%

    4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.

  • GC30782 structure
    GC30782ACY-775
    CAS: 1375466-18-4
    纯度: >99.50%

    An HDAC6 inhibitor

  • GC30785 structure
    GC307854E2RCat
    CAS: 432499-63-3
    纯度: >98.00%

    4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。

  • GC30845 structure
    GC30845Risdiplam (RG7916)
    CAS: 1825352-65-5
    纯度: >99.00%

    Risdiplam (RG7916) 是一种小分子 SMN2 前体 mRNA 剪接修饰剂,可促进外显子 7 的包含和全长 SMN2 mRNA 的产生,从而补偿 SMN1 的损失 。

  • GC30977 structure
    GC30977Ca2+ channel agonist 1
    CAS: 1402821-24-2
    纯度: >99.50%

    Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。

  • GC31187 structure
    GC311875-Methoxyflavone
    CAS: 42079-78-7
    纯度: >99.50%

    5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.

  • GC31365 structure
    GC31365γ-Oryzanol
    CAS: 11042-64-1

    Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).

  • GC31511 structure
    GC31511Sinapinic acid (Sinapic acid)
    CAS: 530-59-6
    纯度: >99.50%

    A phenylpropanoid hydroxycinnamic acid with diverse biological activities

  • GC31650 structure
    GC31650Halofuginone (RU-19110)
    CAS: 55837-20-2
    纯度: >98.00%

    Halofuginone (RU-19110)是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，K i 值为18.3nM。

  • GC31684 structure
    GC31684Dithranol (Anthralin)
    CAS: 1143-38-0
    纯度: >98.00%

    An anthrone inhibitor of keratinocyte proliferation

  • GC31868 structure
    GC31868Thiarabine (OSI-7836)
    CAS: 26599-17-7
    纯度: >99.50%

    Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。

  • GC31879 structure
    GC31879Kira8
    CAS: 1630086-20-2
    纯度: >99.50%

    Kira8 (Ire-1 inhibitor, AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.

  • GC31950 structure
    GC31950Halofuginone hydrobromide (RU-19110 (hydrobromide))
    CAS: 64924-67-0
    纯度: >99.50%

    Halofuginone hydrobromide (RU-19110 (hydrobromide))是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，K i 值为18.3nM。

  • GC32088 structure
    GC32088Gepotidacin (GSK2140944)
    CAS: 1075236-89-3
    纯度: >99.00% / >99.50% / >98.00%

    Gepotidacin (GSK2140944)是一种新型、杀菌性口服三氮杂萘类抗生素，可通过阻断两种必需的拓扑异构酶来抑制细菌DNA复制。

  • GC32181 structure
    GC32181Cefradine (Cephradine)
    CAS: 38821-53-3

    A β-lactam cephalosporin antibiotic

  • GC32186 structure
    GC32186Puromycin (CL13900)
    CAS: 53-79-2
    纯度: {{1-12}>98.00%}

    Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.

  • GC32187 structure
    GC32187Duocarmycin TM
    CAS: 157922-77-5
    纯度: >98.50%

    DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。

  • GC32250 structure
    GC32250Chebulinic acid
    CAS: 18942-26-2
    纯度: >98.00%

    An ellagitannin with diverse biological activities

  • GC32333 structure
    GC32333Beaucage reagent
    CAS: 66304-01-6
    纯度: >98.00%

    Beaucagereagent有效应用于DNA切割。