GlpBio

DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

研究方向

DNA Damage/DNA Repair 相关产品(1788)

  • GC32343 structure
    GC32343Diaveridine (EGIS-5645)
    CAS: 5355-16-8
    纯度: >98.00%

    A DHFR inhibitor with antimicrobial activity

  • GC32401 structure
    GC32401EC0489
    CAS: 1096702-14-5

    EC0489是叶酸和去乙酰长春碱酰肼的偶联物，是叶酸受体(FR)的高亲和力配体。有望治疗难治性或转移性肿瘤。是一种小分子-药物偶联物(SMDC)。

  • GC32429 structure
    GC32429(-)-BAY-1251152
    CAS: 1610358-59-2
    纯度: >99.50%

    A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152

  • GC32565 structure
    GC32565CRA-026440
    CAS: 847460-34-8

    CRA-026440 是一种有效的广谱 HDAC 抑制剂。

  • GC32700 structure
    GC32700CYC065
    CAS: 1070790-89-4
    纯度: >99.50%

    An inhibitor of Cdk2 and Cdk9

  • GC32702 structure
    GC32702Branaplam (LMI070)
    CAS: 1562338-42-4
    纯度: >98.00%

    An SMN2 splice modulator

  • GC32708 structure
    GC32708Forodesine hydrochloride (BCX-1777)
    CAS: 284490-13-7
    纯度: >99.50%

    A nucleoside analog and PNP inhibitor

  • GC32714 structure
    GC32714Mitoxantrone (mitozantrone)
    CAS: 65271-80-9
    纯度: >98.00%

    米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。

  • GC32717 structure
    GC32717AZD4573
    CAS: 2057509-72-3
    纯度: >99.50%

    AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.

  • GC32718 structure
    GC32718M3814 (nedisertib)
    CAS: 1637542-33-6

    M3814 (nedisertib)是一种新型的、具有口服活性的DNA依赖性蛋白激酶（DNA-PK）抑制剂，M3814可抑制DNA-PK的活性来阻断DNA损伤修复通路。

  • GC32720 structure
    GC32720ML364
    CAS: 1991986-30-1
    纯度: >99.50%

    An inhibitor of USP2

  • GC32727 structure
    GC32727GNE-6776
    CAS: 2009273-71-4
    纯度: >98.00%

    GNE-6776 is a potent, non-covalent, selective and orally bioavailable inhibitor of USP7 with IC50 of 1.34 μM and 0.61 μM for full length USP7 and USP7 catalytic domain, respectively.

  • GC32735 structure
    GC32735Samuraciclib hydrochloride (ICEC0942 hydrochloride)
    CAS: 1805789-54-1
    纯度: >99.50%

    Samuraciclib hydrochloride (ICEC0942 hydrochloride, CT7001 hydrochloride) is a new, orally bioavailable CDK7 inhibitor with an IC50 of 40nM. The IC50 values for CDK1, CDK2, CDK5 and CDK9 were 45-, 15-, 230- and 30-fold higher. ICEC0942 (CT7001) promotes cell cycle arrest and apoptosis.

  • GC32739 structure
    GC32739GCN2iB
    CAS: 2183470-12-2
    纯度: >98.00%

    GCN2iB is an ATP-competitive serine/threonine-protein kinase general control nonderepressible 2 (GCN2) inhibitor with IC50 of 2.4 nM.

  • GC32741 structure
    GC32741CCT-251921
    CAS: 1607837-31-9
    纯度: >99.50%

    CCT-251921是有效，选择性，有口服活性的CDK8抑制剂；IC50值为2.3nM。

  • GC32746 structure
    GC32746MSC2530818
    CAS: 1883423-59-3
    纯度: >99.50%

    A Cdk8 inhibitor

  • GC32786 structure
    GC32786FT671
    CAS: 1959551-26-8
    纯度: >98.00%

    FT671是一种是有效的选择性泛素特异性蛋白酶7（USP7）抑制剂，IC 50 值为52nM。

  • GC32793 structure
    GC32793Rucaparib Camsylate
    CAS: 1859053-21-6
    纯度: >99.50%

    A PARP1 inhibitor

  • GC32822 structure
    GC32822TAS-103 dihydrochloride (BMS-247615 dihydrochloride)
    CAS: 174634-09-4
    纯度: >99.50%

    A DNA topoisomerase I and II inhibitor

  • GC32829 structure
    GC32829NU6300
    CAS: 2070015-09-5
    纯度: >96.00% / >98.00%

    NU6300是一种通过共价结合Gasdermin D (GSDMD)蛋白C191位点来特异性抑制细胞焦亡的小分子化合物。

  • GC32832 structure
    GC32832PF-06873600
    CAS: 2185857-97-8

    An inhibitor of Cdk2, Cdk4, and Cdk6

  • GC32838 structure
    GC32838BAY-2402234
    CAS: 2225819-06-5
    纯度: >99.00%

    A DHODH inhibitor

  • GC32845 structure
    GC32845PROTAC CDK9 Degrader-1
    CAS: 2118356-96-8
    纯度: >98.00%

    PROTACCDK9Degrader-1是一种有选择性的CDK9降解剂。

  • GC32856 structure
    GC32856GNE-6640
    CAS: 2009273-67-8
    纯度: >99.50%

    An inhibitor of USP7