DNA Damage/DNA Repair
DNA Damage/DNA Repair(DNA损伤/DNA修复)
- MTH1(4)
- PARP(124)
- ATM/ATR(29)
- DNA Alkylating(25)
- DNA Ligases(3)
- DNA Methyltransferase(32)
- DNA-PK(31)
- HDAC(182)
- Nucleoside Antimetabolite/Analogue(160)
- Telomerase(16)
- Topoisomerase(185)
- tankyrase(5)
- Antifolate(33)
- CDK(271)
- Checkpoint Kinase (Chk)(33)
- CRISPR/Cas9(9)
- Deubiquitinase(76)
- DNA Alkylator/Crosslinker(73)
- DNA/RNA Synthesis(473)
- Eukaryotic Initiation Factor (eIF)(27)
- IRE1(23)
- LIM Kinase (LIMK)(12)
- TOPK(6)
- Casein Kinase(48)
- DNA Intercalating Agents(8)
- DNA/RNA Oxidative Damage(13)
- Poly(ADP-ribose) Glycohydrolase (PARG)(1)
- Early 2 Factor (E2F)(1)
DNA Damage/DNA Repair 相关产品(1788)
- GC32857GSK2850163CAS: 2121989-91-9纯度: >98.00%
GSK2850163是一个新型的肌醇需要酶-1α(IRE1α)抑制剂，它可抑制IRE1α的激酶活性和RNA酶活性，其IC50值分别为20和200nM。
- GC32886Miriplatin (SM-11355)CAS: 141977-79-9纯度: >98.00%
Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation.
- GC32889MKC8866 (IRE-1α inhibitor 1)CAS: 1338934-59-0纯度: >98.00%
MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29?μM for human IRE1α in vitro.
- GC32918Treosulfan (NSC 39069)CAS: 299-75-2纯度: >98.00%
Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines.
- GC329756-Mercaptopurine hydrateCAS: 6112-76-1纯度: >98.50%
An inhibitor of purine synthesis and interconversion
- GC33029Forodesine (BCX-1777 freebase)CAS: 209799-67-7纯度: >98.00%
A nucleoside analog and PNP inhibitor
- GC33050Givinostat (ITF-2357)CAS: 497833-27-9
HDAC inhibitor with anti- inflammatory and antineoplastic activities
- GC33066Belotecan hydrochloride (CKD-602)CAS: 213819-48-8纯度: >98.50% / >98.00%
A DNA topoisomerase I inhibitor
- GC33107(±)-BAY-1251152CAS: 1610358-53-6纯度: >99.50%
A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152
- GC33108Exatecan (DX-8951)CAS: 171335-80-1纯度: >98.00% / >99.50%
Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition.
- GC33115Pomiferin (NSC 5113)CAS: 572-03-2纯度: >98.00%
Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。
- GC33124Datelliptium chlorideCAS: 105118-14-7纯度: >99.50%
Datelliptiumchloride是一种源于ellipticine的DNA嵌合剂，具有抗肿瘤活性。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC32857 | GSK2850163 | 2121989-91-9 | >98.00% | |
GSK2850163是一个新型的肌醇需要酶-1α(IRE1α)抑制剂，它可抑制IRE1α的激酶活性和RNA酶活性，其IC50值分别为20和200nM。 | ||||
| GC32872 | DC_517 | 500017-70-9 | >99.00% | |
DC_517是一种DNMT1抑制剂，IC50和Kd值分别为1.7μM和0.91μM。 | ||||
| GC32885 | GDC-0575 (ARRY-575, RG7741) | 1196541-47-5 | >99.50% | |
A Chk1 inhibitor | ||||
| GC32886 | Miriplatin (SM-11355) | 141977-79-9 | >98.00% | |
Miriplatin (SM-11355) is a derivative of cisplatin containing myristates as a carrier ligand. It is a novel lipophilic platinum complex developed to treat hepatocellular carcinoma.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | ||||
| GC32889 | MKC8866 (IRE-1α inhibitor 1) | 1338934-59-0 | >98.00% | |
MKC8866 (IRE1-IN-8866), a salicylaldehyde analog, is a specific IRE1α RNase inhibitor with IC50 of 0.29?μM for human IRE1α in vitro. | ||||
| GC32898 | SEL120-34A HCl | 1609452-30-3 | - | |
A dual inhibitor of Cdk8 and Cdk19 | ||||
| GC32910 | MKC9989 | 1338934-20-5 | >98.00% | |
MKC9989是一种HAA抑制剂，且能抑制IRE1α其IC50值在0.23μM至44μM的范围之间。 | ||||
| GC32917 | FT827 | 1959537-86-0 | >98.50% | |
FT827是选择性和共价的泛素特异性蛋白酶7(USP7)抑制剂，IC50值为52nM。 | ||||
| GC32918 | Treosulfan (NSC 39069) | 299-75-2 | >98.00% | |
Treosulfan (NSC 39069, Treosulphan) is an alkylating agent used for conventional and high-dose chemotherapy regimens. Treosulfan is potently cytotoxic against pancreatic cancer cell lines. | ||||
| GC32926 | Dxd (Exatecan derivative) | 1599440-33-1 | >98.00% | |
DXd 是 Exatecan (DX-8951) 的衍生物。 | ||||
| GC32930 | Simurosertib (TAK-931) | 1330782-76-7 | >98.00% | |
An inhibitor of Cdc7 kinase | ||||
| GC32946 | PK11007 | 38275-34-2 | >99.00% | |
PK11000 stabilizes the DBD of both WT and mutant p53 proteins by covalent cysteine modification without compromising DNA binding and effective in inducing cell death. | ||||
| GC32964 | NKL 22 | 537034-15-4 | - | |
A selective HDAC1/3 inhibitor | ||||
| GC32970 | MBQ-167 | 2097938-73-1 | >98.00% | |
MBQ-167是Ras相关的C3型肉毒素底物(Rac)和细胞分裂周期蛋白(Cdc42)的双抑制剂，其对Rac1/2/3的IC50值为103nM，对Cdc42的IC50值为78nM。 | ||||
| GC32975 | 6-Mercaptopurine hydrate | 6112-76-1 | >98.50% | |
An inhibitor of purine synthesis and interconversion | ||||
| GC33029 | Forodesine (BCX-1777 freebase) | 209799-67-7 | >98.00% | |
A nucleoside analog and PNP inhibitor | ||||
| GC33049 | FN-1501 | 1429515-59-2 | >98.00% | |
FN-1501 is a potent inhibitor of Fms-like receptor tyrosine kinase 3 (FLT3) and cyclin-dependent kinase (CDK), with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. | ||||
| GC33050 | Givinostat (ITF-2357) | 497833-27-9 | - | |
HDAC inhibitor with anti- inflammatory and antineoplastic activities | ||||
| GC33066 | Belotecan hydrochloride (CKD-602) | 213819-48-8 | >98.50% / >98.00% | |
A DNA topoisomerase I inhibitor | ||||
| GC33094 | GC7 Sulfate | 150417-90-6 | >98.00% | |
A deoxyhypusine synthase inhibitor | ||||
| GC33107 | (±)-BAY-1251152 | 1610358-53-6 | >99.50% | |
A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152 | ||||
| GC33108 | Exatecan (DX-8951) | 171335-80-1 | >98.00% / >99.50% | |
Exatecan (DX-8951) is a nonprodrug camptothecin (CPT) derivative, exhibits significant topoisomerase I inhibition. | ||||
| GC33115 | Pomiferin (NSC 5113) | 572-03-2 | >98.00% | |
Pomiferin (NSC 5113) (NSC 5113) 作为 HDAC 的潜在抑制剂，其 IC50 为 1.05 μM，并且还有效抑制 mTOR (IC50, 6.2 μM)。 | ||||
| GC33124 | Datelliptium chloride | 105118-14-7 | >99.50% | |
Datelliptiumchloride是一种源于ellipticine的DNA嵌合剂，具有抗肿瘤活性。 | ||||