GlpBio

Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

研究方向

Ubiquitination/ Proteasome 相关产品(1292)

  • GC60826 structure
    GC60826Etoposide phosphate
    CAS: 117091-64-2
    纯度: >96.00%

    Etoposidephosphate(BMY-40481)是一种有效的抗癌(anti-cancer)化疗试剂和一种选择性拓扑异构酶II(topoisomeraseII)抑制剂，可以防止DNA链的重新连接。Etoposidephosphate是依托泊苷的磷酸酯前药，被认为与Etoposide活性相当。Etoposidephosphate诱导细胞周期阻滞、凋亡(apoptosis)和自噬(autophagy)。

  • GC60868 structure
    GC60868Gefitinib D8
    CAS: 857091-32-8
    纯度: >98.00%

    GefitinibD8(ZD1839D8)是Gefitinib的氘代物。Gefitinib是一种有效的(EGFR)抑制剂，在NR6wtEGFR细胞中IC50值为2-37nM。

  • GC60882 structure
    GC60882Glyphosate
    CAS: 1071-83-6
    纯度: ≥99.00%

    An herbicide

  • GC60891 structure
    GC60891GW406108X
    CAS: 1644443-92-4
    纯度: >98.00%

    GW406108X (GW108X) is an inhibitor of Kif15 (Kinesin-12) with an IC50 of 0.82 μM in the ATPase assay. GW406108X inhibits recombinant ULK1 kinase activity with a pIC50 of 6.37 and blocks autophagy in cells, without affecting the upstream signalling kinases mTORC1 and AMPK.

  • GC60930 structure
    GC60930Imatinib D4
    CAS: 1134803-16-9

    ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。

  • GC60935 structure
    GC60935Indomethacin sodium hydrate
    CAS: 74252-25-8
    纯度: >98.00%

    A non-selective COX inhibitor

  • GC61003 structure
    GC61003Loperamide D6 hydrochloride
    CAS: 1189469-46-2

    LoperamideD6hydrochloride(R-18553D6hydrochloride)是Loperamidehydrochloride的氘代化合物。Loperamidehydrochloride是一种阿片受体(opioidreceptor)的激动剂，可用于腹泻的研究。

  • GC61045 structure
    GC61045Metformin D6 hydrochloride
    CAS: 1185166-01-1
    纯度: >98.00%

    An internal standard for the quantification of metformin

  • GC61093 structure
    GC61093MSAB
    CAS: 173436-66-3
    纯度: >99.50% / >99.00%

    MSAB（methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate）是一种选择性Wnt/β-catenin信号抑制剂，与β-catenin结合并促进其降解，其EC 50 为0.583μM。

  • GC61155 structure
    GC61155Omeprazole sodium
    CAS: 95510-70-6
    纯度: >98.00%

    An irreversible inhibitor of the gastric proton pump

  • GC61183 structure
    GC61183Physalin B
    CAS: 23133-56-4

    PhysalinB是Capegooseberry中主要的甾体活性成分之一，通过调节p53依赖的凋亡途径，诱导乳腺癌细胞周期阻滞和诱导凋亡(apoptosis)。PhysalinB抑制人结肠癌细胞泛素-蛋白酶体通路并诱导不完全自噬反应。

  • GC61221 structure
    GC61221PTP1B-IN-9
    CAS: 145888-79-5
    纯度: >98.00%

    An inhibitor of the ubiquitin-proteasome system

  • GC61227 structure
    GC61227Quercetin D5
    CAS: 263711-78-0
    纯度: >99.00%

    Quercetin D5是天然产物槲皮素（Quercetin）的氘代同位素内标，其化学结构通常在槲皮素的A环上由5个D原子取代了原有的5个H原子。

  • GC61229 structure
    GC61229Quinacrine dihydrochloride
    CAS: 69-05-6
    纯度: >99.00%

    Quinacrine 2HCl(Quinacrine dihydrochloride) is a lipophilic cationic drug with multiple actions that is commonly used as an anti-protozoal agent. Quinacrine is an effective phospholipase A2 inhibitor.

  • GC61251 structure
    GC61251Rosuvastatin D3
    CAS: 1133429-16-9

    RosuvastatinD3(ZD4522D3)是Rosuvastatin的一种氘代化合物。Rosuvastatin(ZD4522)是一种竞争性HMG-CoA还原酶抑制剂，IC50为11nM。Rosuvastatin有效阻断人类醚-a-go-go相关基因(hERG)电流，IC50为195nM，延迟心脏复极化，从而延长动作电位持续时间(APDs)和校正QT间期(QTc)间隔。

  • GC61256 structure
    GC61256Rupatadine D4 fumarate
    CAS: 1795153-63-7

    RupatadineD4fumarate(UR-12592D4fumarate)是Rupatadinefumarate的氘代标记物。RupatadineFumarate(UR-12592Fumarate)富马酸盐是PAF/H1受体双抑制剂，Ki值分别为0.55μM和0.1μM。

  • GC61263 structure
    GC61263Salvigenin
    CAS: 19103-54-9
    纯度: >99.50%

    A polyphenol flavonoid with diverse biological activities

  • GC61267 structure
    GC61267SAR439859
    CAS: 2114339-57-8
    纯度: >99.50%

    Amcenestrant (SAR439859, compound 43d) is an orally available and nonsteroidal selective estrogen receptor degrader (SERD) with potential antineoplastic activity. SAR439859 is a potent estrogen receptor (ER) antagonist with EC50 of 0.2 nM for ERα degradation.

  • GC61472 structure
    GC61472Zingiberene
    CAS: 495-60-3
    纯度: >97.00%

    Zingiberene(α-Zingiberene)是一种单环倍半萜烯，是姜油的主要成分。具有神经保护潜能。Zingiberene能诱导自噬(autophagy)。具有抗癌活性。

  • GC61520 structure
    GC61520Cilengitide TFA
    CAS: 199807-35-7
    纯度: >99.50%

    An integrin αVβ3 receptor antagonist

  • GC61521 structure
    GC61521Calmodulin-Dependent Protein Kinase II(290-309) acetate
    纯度: >98.50%

    Calmodulin-DependentProteinKinaseII(290-309)acetate是有效的CaMK拮抗剂，抑制抑制Ca2+/钙调蛋白依赖性蛋白激酶II的IC50值为52nM。

  • GC61565 structure
    GC61565Indophagolin
    CAS: 1207660-00-1
    纯度: >98.00%

    Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.

  • GC61669 structure
    GC61669Ethyl 3,4-dihydroxybenzoate
    CAS: 3943-89-3
    纯度: >99.00%

    Ethyl3,4-dihydroxybenzoate(Ethylprotocatechuate)是一种抗氧化剂，是一种在花生种子的种皮中发现的脯氨酰羟化酶(prolyl-hydroxylase)抑制剂。Ethyl3,4-dihydroxybenzoate通过激活NO合酶(NOsynthase)并产生线粒体ROS来保护心肌。Ethyl3,4-dihydroxybenzoate可诱导ESCC细胞自噬(autophagy)和凋亡(apoptosis)。Ethyl3,4-dihydroxybenzoate是胶原蛋白合成抑制剂，具有骨骼保护作用。

  • GC61809 structure
    GC61809Olanzapine D3
    CAS: 786686-79-1
    纯度: >99.00%

    OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。