E3 Ligase(E3 连接酶)

E3 ligases perform the last step in the ubiquitination cascade. They transfer the ubiquitin from the active site cysteine of E2 enzyme to the substrate lysine or N terminus. The loss of function or mis-targeting of the E3 ligases are associated with various cancer types.

Products for E3 Ligase

Cat.No. 产品名称 Information
GC25019 5-amino-2,4-dimethylpyridine (5A-DMP) 5-amino-2,4-dimethylpyridine (5A-DMP) is a novel tandem Tudor domain (TTD)-binding compound that inhibits the full-length UHRF1:LIG1 interaction in Xenopus egg extracts
GC50234 N106
N-(4-甲氧基苯并[D]噻唑-2-基)-5-(4-甲氧基苯基)-1,3,4-噁二唑-2-胺
An activator of SERCA2A sumoylation
GC44291 NAB 2 An inhibitor of α-synuclein-induced toxicity
GC10940 PRT 4165
NSC600157
An inhibitor of PRC1 ubiquitin ligases
GC15492 SMER 3
SCFMET30 Inhibitor, MET30 Antagonist
SMER 3是一种选择性抑制SCFMet30泛素E3连接酶的小分子化合物。
GC11869 SZL P1-41 SZL P1-41是一种特异性S期激酶相关蛋白2（Skp2）抑制剂。
GC15017 NSC 624206 An inhibitor of ubiquitin-activating enzyme (E1)