MAPK Signaling
MAPK Signaling(MAPK信号通路)
MAPK Signaling 相关产品(575)
- GC39074Tenuifoliside ACAS: 139726-35-5纯度: >99.50%
Tenuifoliside A 分离自远志，具有抗凋亡和抗抑郁作用。在 C6 细胞中，Tenuifoliside A 表现出其神经营养作用，并通过 ERK/CREB/BDNF 信号通路促进细胞增殖。
- GC39095Isoliquiritin apiosideCAS: 120926-46-7纯度: >99.50%
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity.
- GC393252,5-DihydroxyacetophenoneCAS: 490-78-8纯度: >99.50%
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways.
- GC39815Semapimod tetrahydrochlorideCAS: 164301-51-3纯度: >98.00%
Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。
- GC40213Regorafenib-13C-d3CAS: 2126178-55-8纯度: >99.00%
An internal standard for the quantification of regorafenib
- GC40231Milrinone-d3CAS: 2749393-50-6纯度: >99.00%
An internal standard for the quantification of milrinone
- GC41573Theaflavin 3,3'-digallateCAS: 30462-35-2纯度: >98.00%
Theaflavin 3,3'-digallate（茶黄素-3,3'-双没食子酸; TF-3; ZP10）是一种有效的寨卡病毒（ZIKV）蛋白酶抑制剂，IC 50 值为2.3μM。
- GC41656(±)2-(14,15-Epoxyeicosatrienoyl) GlycerolCAS: 848667-56-1纯度: >95.00%
A cytochrome P450 metabolite of 2-AG
- GC41740(S)-p38 MAPK Inhibitor IIICAS: 581098-48-8纯度: >98.00%
A cell-permeable p38 MAP kinase inhibitor
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC38708 | Esculin | 531-75-9 | >99.00% | |
A coumarin with antioxidant and anti-inflammatory activities | ||||
| GC38738 | Azosemide | 27589-33-9 | >97.00% | |
Azosemide is a potent Na+–K+–2Cl? cotransporter NKCC1 inhibitor with IC50s of 0.246??M for hNKCC1A and 0.197??M for NKCC1B, respectively. | ||||
| GC38755 | CKI-7 | 120615-25-0 | >99.00% | |
A CK1 inhibitor | ||||
| GC38791 | GSK-25 | 874119-56-9 | >99.50% | |
GSK-25 是一种有效的、选择性的，具有口服活性的 ROCK1 抑制剂 (IC50=7 nM)。GSK-25 对 31 种激酶以及 RSK1 和 p70S6K 保持良好的选择性 (RSK1: IC50=398 nM, p70S6K: IC50=1 μM)。GSK-25 可抑制 P450 (CYP2C9、CYP2D6、CYP3A4的IC50 分别为2.5、5.2、2.5 μM)。 | ||||
| GC38804 | JWG-071 | 2250323-50-1 | >99.50% | |
JWG-071 是首次报道的 ERK5 激酶选择性化学探针。JWG-071 提高了 ERK5 活性和 BRD4 选择性。JWG-071 将是反卷积 ERK5 和 BRD4 药理学急需的化学探针。 | ||||
| GC38917 | Gossypetin | 489-35-0 | >99.00% | |
A flavonoid with diverse biological activities | ||||
| GC39074 | Tenuifoliside A | 139726-35-5 | >99.50% | |
Tenuifoliside A 分离自远志，具有抗凋亡和抗抑郁作用。在 C6 细胞中，Tenuifoliside A 表现出其神经营养作用，并通过 ERK/CREB/BDNF 信号通路促进细胞增殖。 | ||||
| GC39095 | Isoliquiritin apioside | 120926-46-7 | >99.50% | |
Isoliquiritin apioside (ISLA, ILA), a component isolated from Glycyrrhizae radix rhizome (GR), significantly decreases PMA-induced increases in matrix metalloproteinase (MMP) activities and suppresses PMA-induced activation of mitogen-activated protein kinase (MAPK) and NF-κB. Isoliquiritin apioside possesses anti-metastatic and anti-angiogenic abilities in malignant cancer cells and ECs, with no cytotoxicity. | ||||
| GC39325 | 2,5-Dihydroxyacetophenone | 490-78-8 | >99.50% | |
2',5'-Dihydroxyacetophenone (DHAP, 2-Acetylhydroquinone, Quinacetophenone) is a mixture of dihydroxyacetophenone isomers is used in food flavouring. 2',5'-Dihydroxyacetophenone significantly inhibits NO production via the suppression of iNOS expression. 2',5'-Dihydroxyacetophenone significantly decreases levels of the pro-inflammatory cytokines TNF-α and IL-6 by blocking the ERK1/2 and NF-κB signaling pathways. | ||||
| GC39485 | CK2/ERK8-IN-1 | 1085822-09-8 | >99.00% | |
A dual inhibitor of CK2 and ERK8 | ||||
| GC39574 | SR-318 | 2413286-32-3 | >98.50% | |
A dual inhibitor of p38α and p38β MAPKs | ||||
| GC39715 | M2698 | 1379545-95-5 | >99.50% | |
A dual inhibitor of p70S6K and Akt1 | ||||
| GC39815 | Semapimod tetrahydrochloride | 164301-51-3 | >98.00% | |
Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。 | ||||
| GC40054 | CCT241161 | 1163719-91-2 | >98.00% | |
A multi-kinase inhibitor | ||||
| GC40213 | Regorafenib-13C-d3 | 2126178-55-8 | >99.00% | |
An internal standard for the quantification of regorafenib | ||||
| GC40231 | Milrinone-d3 | 2749393-50-6 | >99.00% | |
An internal standard for the quantification of milrinone | ||||
| GC40352 | Cafestol | 469-83-0 | >98.00% | |
Cafestol是咖啡中主要活性成分之一，是一种咖啡特异性二萜类化合物，具有ERK2抑制活性。 | ||||
| GC40484 | Ferulic Acid methyl ester | 2309-07-1 | >99.00% | |
A lipophilic antioxidant | ||||
| GC40650 | CAY10706 | 1881270-27-4 | >95.00% | |
A TrxR inhibitor | ||||
| GC41423 | 5-trans Prostaglandin E2 | 36150-00-2 | >98.00% | |
An impurity in commercial lots of PGE 1 | ||||
| GC41573 | Theaflavin 3,3'-digallate | 30462-35-2 | >98.00% | |
Theaflavin 3,3'-digallate（茶黄素-3,3'-双没食子酸; TF-3; ZP10）是一种有效的寨卡病毒（ZIKV）蛋白酶抑制剂，IC 50 值为2.3μM。 | ||||
| GC41635 | Phosphodiesterase 4 Inhibitor | 346440-86-6 | >98.00% | |
An inhibitor of PDE4 | ||||
| GC41656 | (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol | 848667-56-1 | >95.00% | |
A cytochrome P450 metabolite of 2-AG | ||||
| GC41740 | (S)-p38 MAPK Inhibitor III | 581098-48-8 | >98.00% | |
A cell-permeable p38 MAP kinase inhibitor | ||||