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DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

研究方向

DNA Damage/DNA Repair 相关产品(1788)

  • GC34087 structure
    GC34087Trilaciclib hydrochloride (G1T28 hydrochloride)
    CAS: 1977495-97-8
    纯度: >98.00%

    Trilaciclib hydrochloride (G1T28 hydrochloride) (G1T28 hydrochloride) 是一种 CDK4/6 抑制剂，对 CDK4 和 CDK6 的 IC50 分别为 1 nM 和 4 nM。

  • GC34090 structure
    GC34090Acelarin (NUC-1031)
    CAS: 840506-29-8
    纯度: >99.50%

    A prodrug form of gemcitabine

  • GC34100 structure
    GC34100Lerociclib dihydrochloride (G1T38 dihydrochloride)
    CAS: 2097938-59-3
    纯度: >99.50%

    Lerociclib dihydrochloride (G1T38 dihydrochloride) (G1T38 dihydrochloride) 是一种有效的选择性 CDK4/CDK6 抑制剂，对 CDK4/CyclinD1 和 CDK6/CyclinD3 的 IC50 分别为 1 nM 和 2 nM。

  • GC34111 structure
    GC34111NSC95682 (6-Bromo-2-hydroxy-3-methoxybenzaldehyde)
    CAS: 20035-41-0
    纯度: >99.50%

    6-Bromo-2-hydroxy-3-methoxybenzaldehyde is a bromobenzaldehyde derivative that participates in the synthesis of (±)-norannuradhapurine. 6-Bromo-2-hydroxy-3-methoxybenzaldehyde is an IRE-1α inhibitor with an IC50 of 0.08 μM.

  • GC34112 structure
    GC34112Ethynylcytidine (ECyD)
    CAS: 180300-43-0
    纯度: >99.50%

    A nucleoside analog with anticancer activity

  • GC34118 structure
    GC34118Trilaciclib (G1T28)
    CAS: 1374743-00-6

    Trilaciclib (G1T28, G1T28-1) is a highly potent, selective and reversible cyclin-dependent kinase 4 and 6 (CDK4/6) inhibitor. Trilaciclib inhibits CDK4/cyclin D1 and CDK6/cyclin D3 with IC50 of 1 nM and 4 nM, respectively.

  • GC34120 structure
    GC34120Niraparib R-enantiomer (MK 4827 (R-enantiomer))
    CAS: 1038915-58-0
    纯度: >99.50%

    Niraparib R-enantiomer (MK-4827 R-enantiomer) 是一种出色的 PARP1 抑制剂，IC50 为 2.4 nM。

  • GC34121 structure
    GC34121CC-115 hydrochloride
    CAS: 1300118-55-1
    纯度: >98.00%

    A dual inhibitor of mTOR and DNA-PK

  • GC34123 structure
    GC34123Deoxycytidine triphosphate (dCTP)
    CAS: 2056-98-6

    脱氧胞苷三磷酸 (dCTP) (dCTP) 是一种核苷三磷酸，可用于 DNA 合成。

  • GC34124 structure
    GC34124(rel)-MC180295
    CAS: 2237942-08-2
    纯度: >98.00%

    MC180295 ((rel)-MC180295) is a novel potent and selective CDK9 inhibitor with an IC50 of 5 nM and is at least 22-fold more selective for CDK9 over other CDKs.

  • GC34127 structure
    GC34127GDC-0575 dihydrochloride (ARRY-575 dihydrochloride)
    CAS: 1657014-42-0
    纯度: >99.50%

    A Chk1 inhibitor

  • GC34144 structure
    GC34144Karenitecin (Cositecan)
    CAS: 203923-89-1
    纯度: >98.00%

    Karenitecin (Cositecan) (Cositecan) 是一种拓扑异构酶 I 抑制剂，具有有效的抗癌活性。

  • GC34156 structure
    GC34156Namitecan (ST-1968)
    CAS: 372105-27-6
    纯度: >98.00%

    Namitecan (ST-1968) 是一种有效的拓扑异构酶 I 抑制剂，具有抗肿瘤特性。

  • GC34163 structure
    GC34163Lerociclib (G1T38)
    CAS: 1628256-23-4

    G1T38 (Lerociclib) is a novel, potent, selective, and orally bioavailable CDK4/6 inhibitor with IC50 values of 0.001 μM, 0.002 μM and 0.028 μM for CDK4, CDK6 and CDK9 respectively.

  • GC34165 structure
    GC34165Corin
    CAS: 1808113-09-8
    纯度: >98.00%

    Corin是组氨酸赖氨酸特异性去甲基化酶(LSD1)和组氨酸脱乙酰化酶(HDAC)的双重抑制剂，其对LSD1的Ki(inact)值为110nM，对HDAC1的IC50值为147nM。

  • GC34169 structure
    GC34169Banoxantrone D12 dihydrochloride (AQ4N D12 dihydrochloride)
    CAS: 1562066-98-1
    纯度: >98.00%

    Banoxantrone-d12 (AQ4N-d12) dihydrochloride 是氘标记的 Banoxantrone dihydrochloride。 Banoxantrone 是一种新型生物还原剂，可以还原为稳定的 DNA 亲和化合物 AQ4，它是一种有效的拓扑异构酶 II 抑制剂。

  • GC34195 structure
    GC34195K-756
    CAS: 130017-40-2
    纯度: >99.00%

    K-756是一种直接的选择性tankyrase(TNKS)抑制剂，抑制TNKS1和TNKS2的ADP-核糖基化活性，IC50分别为31和36nM。

  • GC34204 structure
    GC34204JSH-150
    CAS: 2247481-21-4
    纯度: >98.00%

    JSH-150 is a highly selective and potent inhibitor of CDK9 with IC50 of 1 nM.

  • GC34205 structure
    GC34205GSK2850163 hydrochloride
    CAS: 2319838-09-8

    GSK2850163hydrochloride是一个新型的肌醇需要酶-1α(IRE1α)抑制剂，它可抑制IRE1α的激酶活性和RNA酶活性，其IC50值分别为20和200nM。

  • GC34305 structure
    GC34305Bendamustine D4 (SDX-105 D4)

    BendamustineD4是Bendamustine的氘代化合物标准品。Bendamustine是一种DNA交联剂(DNAcrosslinker)，能够导致DNA断裂，具有烷基化和抗代谢物的作用。

  • GC34309 structure
    GC34309Cycloguanil D6 (Chlorguanide triazine D6)

    CycloguanilD6是Cycloguanil的氘代化合物标准品。

  • GC34354 structure
    GC34354GSK2643943A
    CAS: 2449301-27-1
    纯度: >98.00%

    GSK2643943A是一种靶向USP20的去泛素化酶（DUB）抑制剂，GSK2643943A通过抑制USP20/Ub-Rho（IC 50 =160nM）的活性来阻断蛋白质-泛素键的裂解。

  • GC34355 structure
    GC34355SEL120-34A monohydrochloride
    纯度: >99.50%

    A dual inhibitor of Cdk8 and Cdk19

  • GC34356 structure
    GC34356Casein Kinase II Inhibitor IV Hydrochloride
    CAS: 2320347-54-2

    CaseinKinaseIIInhibitorIVHydrochloride是表皮角质形成细胞分化的小分子诱导剂。