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Home >> Signaling Pathways >> DNA Damage/DNA Repair

DNA Damage/DNA Repair(DNA损伤/DNA修复)

  1. Cat.No. 产品名称 Information
  2. GC32718 M3814 (nedisertib)

    M3814

     M3814 (nedisertib)是一种新型的、具有口服活性的DNA依赖性蛋白激酶（DNA-PK）抑制剂，M3814可抑制DNA-PK的活性来阻断DNA损伤修复通路。
  3. GC32717 AZD4573 AZD4573 is a potent inhibitor of CDK9 (IC50 of <0.004 μM) with fast-off binding kinetics (t1/2 = 16 min) and high selectivity versus other kinases, including other CDK family kinases.
  4. GC32714 Mitoxantrone (mitozantrone)

    米托蒽醌; Mitozantrone; NSC 301739

     米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。
  5. GC32708 Forodesine hydrochloride (BCX-1777)

    BCX-1777 hydrochloride; Immucillin-H hydrochloride

     A nucleoside analog and PNP inhibitor
  6. GC32702 Branaplam (LMI070)

    LMI070; NVS-SM1

     An SMN2 splice modulator
  7. GC32700 CYC065

    CYC065

     An inhibitor of Cdk2 and Cdk9
  8. GC32565 CRA-026440 CRA-026440 是一种有效的广谱 HDAC 抑制剂。
  9. GC32429 (-)-BAY-1251152

    (-)-BAY-1251152; (-)-VIP152

     A racemic mixture of (+)-BAY-1251152 and (–)-BAY-1251152
  10. GC32401 EC0489 EC0489是叶酸和去乙酰长春碱酰肼的偶联物，是叶酸受体(FR)的高亲和力配体。有望治疗难治性或转移性肿瘤。是一种小分子-药物偶联物(SMDC)。
  11. GC32343 Diaveridine (EGIS-5645)

    二氨藜芦啶; EGIS-5645

     A DHFR inhibitor with antimicrobial activity
  12. GC32333 Beaucage reagent

    Beaucage试剂

     Beaucagereagent有效应用于DNA切割。
  13. GC32250 Chebulinic acid

    诃子林鞣酸

     An ellagitannin with diverse biological activities
  14. GC32187 Duocarmycin TM

    CBI-TMI

     DuocarmycinTM是一种非常有效的有抗肿瘤活性的抗生素。
  15. GC32186 Puromycin (CL13900)

    嘌呤霉素二盐酸盐水合物

    Puromycin 2HCl (CL13900) is an aminonucleoside antibiotic, which acts as a protein synthesis inhibitor.
  16. GC32181 Cefradine (Cephradine)

    头孢拉定; Cefradine; SQ-11436

     A β-lactam cephalosporin antibiotic
  17. GC32088 Gepotidacin (GSK2140944)

    GSK2140944

     Gepotidacin (GSK2140944)是一种新型、杀菌性口服三氮杂萘类抗生素，可通过阻断两种必需的拓扑异构酶来抑制细菌DNA复制。
  18. GC31950 Halofuginone hydrobromide (RU-19110 (hydrobromide))

    常山酮溴酸盐; RU-19110 hydrobromide

     Halofuginone hydrobromide (RU-19110 (hydrobromide))是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，Ki值为18.3nM。
  19. GC31879 Kira8

    AMG-18

    Kira8 (Ire-1 inhibitor, AMG-18) is a mono-selective IRE1α inhibitor that allosterically attenuates IRE1α RNase activity with an IC50 of 5.9 nM.
  20. GC31868 Thiarabine (OSI-7836)

    OSI-7836

     Thiarabine (OSI-7836) (OSI-7836) 显示出有效的抗肿瘤活性和对 DNA 合成的抑制作用。
  21. GC31684 Dithranol (Anthralin)

    蒽林; Anthralin

     An anthrone inhibitor of keratinocyte proliferation
  22. GC31650 Halofuginone (RU-19110)

    常山酮; RU-19110

     Halofuginone (RU-19110)是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，Ki值为18.3nM。
  23. GC31511 Sinapinic acid (Sinapic acid)

    芥子酸; Sinapic acid

     A phenylpropanoid hydroxycinnamic acid with diverse biological activities
  24. GC31365 γ-Oryzanol

    γ-谷维素

     Gamma-oryzanol (GO), a nutriactive phytochemical naturally occurring in crude rice bran oil, is an antioxidant compound used to treat hyperlipidemia, disorders of menopause and to increase the muscle mass. γ-Oryzanol is a potent DNA methyltransferases (DNMTs) inhibitor in the striatum of mice. γ-Oryzanol significantly inhibits the activities of DNMT1 (IC50=3.2 μM), DNMT3a (IC50=22.3 μM).
  25. GC31187 5-Methoxyflavone

    5-甲氧基黄酮

     5-methoxyflavone is a novel DNA polymerase-beta inhibitor and neuroprotective agent against beta-amyloid toxicity.
  26. GC30977 Ca2+ channel agonist 1 Ca2+channelagonist1是一种N-型钙离子通道(N-typeCa2+channel)激动剂和Cdk2的抑制剂，EC50分别为14.23μM和3.34μM，对运动神经终端功能障碍有潜在疗效。
  27. GC30845 Risdiplam (RG7916)

    RG7916; RO7034067

    Risdiplam (RG7916) 是一种小分子 SMN2 前体 mRNA 剪接修饰剂,可促进外显子 7 的包含和全长 SMN2 mRNA 的产生,从而补偿 SMN1 的损失 。
  28. GC30785 4E2RCat 4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。
  29. GC30782 ACY-775 An HDAC6 inhibitor
  30. GC30763 Benzenebutyric acid (4-Phenylbutyric acid)

    4-苯基丁酸; 4-PBA; Benzenebutyric acid

    4-Phenylbutyric acid (4-PBA, Benzenebutyric acid) is a histone deacetylase (HDAC) inhibitor and a key epigenetic inducer of anti-HCV hepatic hepcidin. 4-Phenylbutyric acid inhibits LPS-induced inflammation through regulating endoplasmic-reticulum (ER) stress and autophagy in acute lung injury models.
  31. GC30695 Phen-DC3

    Phen-DC3是一个G4特异性配体，可以抑制解旋酶FANCJ和DinG且IC50s值分别为65±6和50±10nM。
  32. GC30554 Isocytosine

    异胞嘧啶

    Isocytosine (2-aminouracil) is an isomer of cytosine used in physical chemical studies involving metal complex binding, hydrogen-bonding, and tautomerism and proton transfer effects in nucleobases.
  33. GC30548 6-Amino-5-nitropyridin-2-one

    6-氨基-5-硝基-2(1H)-吡啶酮

     6-Amino-5-nitropyridin-2-one是一种吡啶碱基，可用作hachimojiDNA的核酸碱基，并与5-aza-7-脱氮鸟嘌呤配对。
  34. GC30531 7-Methylguanosine

    7-甲基鸟苷

     A methylated form of guanosine
  35. GC30529 GNE-371 GNE-371是一种针对人类转录起始因子TFIID亚基1和类转录起始因子TFIID亚基1的第二溴端结构域的高效选择性化学探针，对TAF1(2)的IC50值为10nM。
  36. GC30526 ACY-957 ACY-957是一种选择性的HDAC1和HDAC2抑制剂，对HDAC1/2/3的IC50值分别为7nM，18nM和1300nM，对HDAC4/5/6/7/8/9无作用。
  37. GC30466 CDK8-IN-3 CDK8-IN-3是CDK8的抑制剂,来自专利WO2016041618A1，化合物实例1.7。
  38. GC30276 Casein Kinase II Inhibitor IV

    CaseinKinaseIIInhibitorIV是表皮角质形成细胞分化的小分子诱导剂。
  39. GC30245 CLK1-IN-1 CLK1-IN-1是一个有效的、Cdc2-like激酶(CLK1)的选择性抑制剂，其IC50值为2nM。
  40. GC30185 SMN-C3 SMN-C3是一种可口服的SMN2剪接调节剂，有治疗脊椎肌肉萎缩(SMA)的潜力。
  41. GC30106 CHK1 inhibitor

    GDC-0575 analog

     CHK1inhibitor是CHK1的抑制剂。
  42. GC19468 AZD1390 AZD1390是一种新型选择性共济失调毛细血管扩张突变激酶抑制剂，能够高效穿透血脑屏障。
  43. GC19451 SBI-0640756

    SBI-756

     SBI-0640756 (SBI-756) 是 eIF4G1 的抑制剂，可破坏 eIF4F 复合物。
  44. GC19406 TH34 TH34 是一种 HDAC6/8/10 抑制剂，IC50 分别为 4.6 μM、1.9 μM 和 7.7 μM，对 HDAC1/2/3 具有高选择性。
  45. GC19391 Zoliflodacin

    ETX0914; AZD0914

     A fluoroquinolone antibiotic
  46. GC19390 YU238259 An inhibitor of homology-dependent DNA repair
  47. GC19378 VLX1570 VLX1570 is an inhibitor of 19S proteasomal deubiquitinases
  48. GC19360 TMP195

    TMP195游离态

    TMP195 是一种有效的选择性 IIa 类 HDAC 抑制剂，对 HDAC4、HDAC5、HDAC7 和 HDAC9 的 IC50 分别为 59 nM、60 nM、26 nM 和 15 nM。
  49. GC19348 TAS-102

    TAS-102

     An orally bioavailable combination of a nucleoside analog and TPase inhibitor
  50. GC19342 SW044248 A DNA topoisomerase I inhibitor
  51. GC19337 SR-4370 An HDAC3 inhibitor

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