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Home >> Signaling Pathways >> PI3K/Akt/mTOR Signaling

PI3K/Akt/mTOR Signaling(PI3K/Akt/mTOR 信号传导)

  1. Cat.No. 产品名称 Information
  2. GC18810 GSK3β Inhibitor XI

    GSK-3BETA抑制剂XI

    A potent inhibitor of GSK3β
  3. GC18583 D-α-Hydroxyglutaric Acid

    R-2-羟基戊二酸,(R)-2-Hydroxyglutarate; (R)-2-Hydroxyglutaric acid; (R)-2-Hydroxypentanedioic acid

     D-α-Hydroxyglutaric Acid是α-酮戊二酸（α-KG）的弱竞争性拮抗剂（Ki = 10.87mM）。
  4. GC18479 SAR260301

    (S)-2-(2-(2-甲基吲哚啉-1-基)-2-氧代乙基)-6-吗啉嘧啶-4(3H)-酮

     A selective PI3Kβ inhibitor
  5. GC18374 API-1

    NSC 177223

     An Akt inhibitor
  6. GC18322 CAY10567

    BML257

     An Akt1 translocation inhibitor
  7. GC18208 YLF-466D

    3-[[(3E)-3-[(4-氯苯基)苯基亚甲基]-2,3-二氢-2-氧代-1H-吲哚-1-基]甲基]苯甲酸,C24

     An AMPK activator
  8. GC18164 UCB9608

    (S)-4-(6-氨基-1-甲基-1H-吡唑并[3,4-D]嘧啶-4-基)-N-(4-甲氧基-2-甲基苯基)-3-甲基哌嗪-1-甲酰胺

     UCB9608 是一种有效、选择性和口服活性的 PI4KIIIβ 抑制剂，IC50 为 11 nM，对 PI3KC2 α、β 和 γ 脂质激酶具有选择性。
  9. GC11607 Rapalink-1 第三代二价 mTOR 抑制剂 RapaLink-1 通过惰性化学接头将雷帕霉素与 MLN0128 结合。 RapaLink-1 显示出比雷帕霉素或 mTOR 激酶抑制剂 (TORKi) 更好的功效，可有效阻断癌症衍生的激活 mTOR 突变体。 RapaLink-1 可以穿过血脑屏障。 RapaLink-1 与 FKBP12 的结合导致 mTORC1 的靶向和持久抑制。 RapaLink-1 通过改善自噬在抗磷脂综合征中发挥抗血栓作用。抗癌活性。
  10. GC10228 GDC-0084 PI3K and mTOR inhibitor, brain-permeable
  11. GC13992 3-Guanidinopropionic Acid

    胍基丙酸; RGX-202; 3-Guanidinopropionic acid

     A creatine analog
  12. GC15841 Alsterpaullone

    阿特波龙,9-Nitropaullone,NSC 705701

     A dual CDK and GSK3 inhibitor
  13. GC15553 KP372-1 An Akt inhibitor
  14. GC15595 GSK2269557 A selective inhibitor of PI3Kδ
  15. GC10857 UCN-01

    NSC 638850,​7-hydroxy Staurosporine

     A nonspecific protein kinase inhibitor
  16. GC11907 NSC 210902 A selective CK2 inhibitor
  17. GC11190 AMPK activator

    D942

     A cell-permeable activator of AMPK
  18. GC16187 GSK-3β Inhibitor II

    4-[5-[[(3-碘苯基)甲基]硫基]-1,3,4-恶二唑-2-基]吡啶,Tip-oxadiazole

     An inhibitor of GSK3β signaling
  19. GC11910 AS-041164 Selective inhibitor of PI3Kγ
  20. GC16534 Ampkinone A small molecule activator of AMPK
  21. GC15740 OXA-01 A selective dual inhibitor of mTORC1 and mTORC2
  22. GC16960 4,5,6,7-Tetrabromobenzimidazole

    4,5,6,7-四溴苯并咪唑,Casein Kinase II Inhibitor XII,TBBz

     A selective inhibitor of CK2
  23. GC14181 TBCA

    Casein Kinase II Inhibitor III,Tetrabromocinnamic Acid

     An inhibitor of casein kinase 2
  24. GC12416 INK1117

    [6-(2-氨基-5-苯并恶唑基)咪唑并[1,2-A]吡啶-3-基]-4-吗啉基甲酮,MLN1117,TAK-117;Serabelisib

    A selective inhibitor of PI3Kα
  25. GC13176 CP21R7

    GSK-3Β抑制剂(CP21R7),CP21

     A GSK3β inhibitor used to differentiate stem cells
  26. GC12889 PX 866

    PX-866

     An inhibitor of PI3K
  27. GC10436 VPS34-IN1

    Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1

     A potent and selective inhibitor of Vps34
  28. GC11248 AZD8835 An inhibitor of PI3Kα and PI3Kδ
  29. GC15679 GSK2292767 A potent and selective inhibitor of PI3Kδ
  30. GC13648 CC-223

    CC-223; ATG-008

     A potent, selective inhibitor of mTOR
  31. GC16039 LJH685

    2,6-二氟-4-[4-[4-(4-甲基-1-哌嗪基)苯基]-3-吡啶基]苯酚

     An inhibitor of RSKs
  32. GC14679 PIK-III

    Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2

     A selective inhibitor of Vps34
  33. GC16654 CC-115 A dual inhibitor of mTOR and DNA-PK
  34. GC14371 LY3023414

    LY3023414

     LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
  35. GC16601 LJI308 An inhibitor of RSKs
  36. GC11724 GSK621

    6-氯-5-(2'-羟基-3'-甲氧基-[1,1'-联苯]-4-基)-3-(3-甲氧基苯基)-1H-吡咯并[3,2-D]嘧啶-2,4(3H,5H)-二酮

     GSK621是一种特异性的AMP活化蛋白激酶（AMPK）激动剂。GSK621可通过激活AMPK信号通路来诱导自噬和细胞凋亡。
  37. GC13913 AMG319 Potent, selective PI3Kδ inhibitor
  38. GC12576 AZD8186

    8-[(1R)-1-[(3,5-二氟苯基)氨基]乙基]-N,N-二甲基-2-(4-吗啉基)-4-氧代-4H-1-苯并吡喃-6-甲酰胺

     A PI3Kβ/δ inhibitor
  39. GC12375 PF-4989216

    4-(4-氰基-2-氟苯基)-2-吗啉-5-(1H-1,2,4-三唑-5-基)噻吩-3-腈

     An orally bioavailable PI3K inhibitor
  40. GC13790 MHY1485 MHY1485 是一种有效的 mTOR 激活剂，可抑制自噬以及自噬体与溶酶体之间的融合。
  41. GC17500 SU6656 SU6656是一种小分子吲哚酮类化合物，可选择性抑制Src、Yes和Fyn激酶活性，IC50值分别为0.28μM、0.02μM和0.17μM。
  42. GC15615 BX517(PDK1 inhibitor2)

    PDK1 Inhibitor II

     An inhibitor of PDK1
  43. GC10860 Acalisib (GS-9820)

    GS-9820; CAL-120

     An inhibitor of p110δ
  44. GC12089 LY2584702 A p70S6K inhibitor
  45. GC17338 GNE-317 A dual PI3Kα and mTOR inhibitor
  46. GC11325 CX-4945 sodium salt

    CX-4945 sodium salt

     A potent, orally bioavailable CK2 inhibitor
  47. GC10752 Bikinin

    Abrasin

     Bikinin是一种具有ATP竞争性的非甾体类植物GSK-3（糖原合酶激酶3）/Shaggy-like激酶抑制剂。
  48. GC11471 SAR405 SAR405是一种Vps34抑制剂(IC50=1.2 nM)，SAR405抑制mTOR抑制引起的自噬。
  49. GC12162 ZLN024 hydrochloride An allosteric activator of AMPK
  50. GC16475 Afuresertib

    GSK2110183

     A pan-Akt inhibitor
  51. GC16617 IM-12

    GSK3β Inhibitor XIX

     A GSK3β inhibitor

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