Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC17623 Alvimopan

爱维莫潘; ADL 8-2698; LY 246736
A μ-opioid receptor antagonist
GC12619 Alvimopan dihydrate

爱维莫潘; ADL 8-2698 dihydrate; LY 246736 dihydrate
A μ-opioid receptor antagonist
GC35311 Alvimopan monohydrate

爱维莫潘水合物; ADL 8-2698 monohydrate; LY 246736 monohydrate
A μ-opioid receptor antagonist
GC13664 AM580

4-[(5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基)甲酰氨基]苯甲酸,CD336; NSC608001; Ro 40-6055
A selective RARα agonist
GC16433 Aminoglutethimide

氨鲁米特,DL-Aminoglutethimide
An aromatase inhibitor
GC63932 Amsilarotene

4-[[3,5-二(三甲基硅烷基)苯甲酰基]氨基]苯甲酸,TAC-101; Am 555S
Amsilarotene (TAC-101; Am 555S) 是一种具有口服活性的合成类视黄醇，对视黄酸受体 α (RAR-α) 具有选择性亲和力，对 RAR-α 和 RAR-β 的 Ki 值为 2.4 nM 和 400 nM。Amsilarotene 诱导人胃癌、肝细胞癌和卵巢癌细胞的凋亡 (apoptotic)。Amsilarotene 可用于癌症研究。
GC42793 Amylin (1-13) (human, mouse, rat), (trifluoroacetate salt)

IAPP (1-13) (human, mouse rat), Islet Amyloid Polypeptide (1-13) (human. mouse, rat)
A peptide fragment of amylin
GC42795 Amylin (human) (amidated) (trifluoroacetate salt)

IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated)
A peptide hormone
GC42797 Amylin (rat, mouse) (trifluoroacetate salt)

IAPP (rat, mouse), Islet Amyloid Polypeptide (rat, mouse)
A peptide hormone
GC10256 Anastrozole

阿那曲唑; ZD1033
An aromatase/CYP19A1 inhibitor
GC46854 Anastrozole-d12

ZD1033-d12
An internal standard for the quantification of anastrozole
GC13685 Andarine

S-4
A selective androgen receptor modulator
GC67698 Androgen receptor-IN-2 Androgen receptor-IN-2 是一种有效的、具有口服活性的 Androgen Receptor 抑制剂。Androgen receptor-IN-2 对前列腺癌具有抗肿瘤活性。
GC73577 Androgen receptor-IN-6 Androgen receptor-IN-6（化合物16）是一种口服雄激素受体（雄激素受体）强效抑制剂（体外IC50=0.12μM），靶向无序的N-末端结构域（NTD）。
GC31254 Androst-4-ene-3,17-diol, dipropanoate, (3β,17β)- (Androst-4-ene-3β,17β-diol, dipropionate)
Androst-4-ene-3,17-diol,dipropanoate,(3β,17β)-是睾酮代谢物4-雄烯二醇的二丙酸酯。
GC34887 Androstanolone acetate

雄诺龙醋酸酯
Androstanoloneacetate是一种雄激素配体，靶向作用于雄激素受体α(AR)。Androstanoloneacetate通过连接桥与cIAP1配体Bestatin结合从而形成PROTAC分子。
GC30842 Androsterone (5α-Androstan-3α-ol-17-one)

雄酮; 5α-Androstan-3α-ol-17-one

An androgenic steroid
GP10074 Angiotensin 1/2 (1-5)

H2N-Asp-Arg-Val-Tyr-Ile-OH

血管紧张素 I/II 1-5 是一种含有氨基酸 1-5 的肽，由血管紧张素 I/II 转化而来。
GP10067 Angiotensin 1/2 (1-6)

H2N-Asp-Arg-Val-Tyr-Ile-His-OH

血管紧张素 I/II 1-6 含有氨基酸 1-6，由血管紧张素 I/II 肽转化而来。
GP10144 Angiotensin 1/2 (1-7) amide

H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-amide

Vasoconstrictor
GP10012 Angiotensin 1/2 (1-8) amide

H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-amide

Vasoconstrictor
GP10025 Angiotensin 1/2 (1-9)

血管紧张素I,H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH

血管收缩药
GP10045 Angiotensin 1/2 (2-7)

H2N-Arg-Val-Tyr-Ile-His-Pro-OH

Vasoconstrictor
GP10079 Angiotensin 1/2 (5-7)

H2N-Ile-His-Pro-OH

Vasoconstrictor
GP10120 Angiotensin 1/2 + A (2 - 8)

H2N-Ala-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
Vasoconstrictor
GC52415 Angiotensin A (trifluoroacetate salt)

Ala-Arg-Val-Tyr-Ile-His-Pro-Phe, DesAsp1-Ala1-Ang II
An AT₁ and AT₂ receptor agonist and active metabolite of angiotensin II
GP10087 Angiotensin I (human, mouse, rat)

血管紧张素 1 (人)

血管紧张素 I（人、小鼠、大鼠）是血管收缩肽血管紧张素 II 的前体，被血管紧张素转换酶 (ACE) 裂解。
GC46856 Angiotensin II (5-8) (human, rat, mouse) (trifluoroacetate salt)

Angiotensin (5-8)
An endogenous angiotensin II fragment
GC42815 Ansatrienin A

安三烯菌素A
An ansamycin antibiotic and antifungal
GC46859 Antide (acetate)

N-((4R,7R,10R,13S,16S,19R)-19-(((S)-1-(((S)-1-((S)-2-((R)-1-氨基-1-氧代丙烷-2-基)氨基甲酰基)吡咯烷-1-基)-6-(异丙基氨基)-1-氧代己基-2-基)氨基)-4-甲基-1-氧代戊烷-2-基)氨基甲酰基)-7-(4-氯苄基)-13-(羟甲基)-4-(萘-2-基甲基)-16-(4-(烟酰胺基)丁基)-2,5,8,11,14,17-六氧代-10-(吡啶-3-基甲基)-3,6,9,12,15,18-六氮杂二十三烷-23-基)烟酰胺乙酸盐
A GnRHR antagonist
GC46860 AP-238 (hydrochloride)

2,6-dimethyl Propionyl AP-237
A neuropeptide with diverse biological activities
GC60589 Apalutamide D4

ARN-509-d4
ApalutamideD4(ARN-509D4)是Apalutamide的一种氘代化合物。Apalutamide是有效，竞争性的雄激素受体(AR)拮抗剂，IC50为16nM。
GC12219 AR-M 1000390 hydrochloride AR-M 1000390 hydrochloride 是一种特别选择性的强效 δ 阿片受体激动剂，δ 激动剂效力的 EC50 为 7.2±0.9 nM。
GC64540 Ar-V7-IN-1 Ar-V7-IN-1 是一种有效的 Ar-V7 抑制剂。AR-V7 是雄激素受体的一种激素非依赖性剪接变体。Ar-V7-IN-1具有研究各种适应症的潜力，特别是前列腺癌等癌症 (信息提取自专利 WO2018114781A1, 化合物 43)。
GC19035 AR7 A RARα antagonist
GC73613 ARD-1676 ARD-1676是一种口服雄激素受体（AR） PROTAC降解剂，由AR配体和小脑配体组成。
GC73277 ARD-2051 ARD-2051是一种有效的口服活性雄激素受体（AR）蛋白水解靶向嵌合体降解剂。
GC72850 ARD-69 ARD-69（化合物34）是一种有效的PROTAC雄激素受体降解剂。
GC42852 Arginine Vasotocin (trifluoroacetate salt)

Arg8-Vasotocin, AVT
A nonapeptide agonist of the AVT receptor
GC16840 ARN-509

阿帕鲁胺,ARN 509; ARN509, Apalutamide
ARN-509是一种合成的双芳基硫代乙内酰脲化合物，抑制雄激素受体（AR），IC₅₀值为16nM。
GC62118 ARV-110

ARV-110
Bavdegalutamide (ARV-110) is an orally bioavailable, specific androgen receptor (AR) PROTAC degrader that leads to ubiquitination and degradation of AR. ARV-110 completely degrades androgen receptor (AR) in all cell lines tested with DC50 of < 1 nM. ARV-110 can be used for the research of prostate cancer.
GC10547 ASC-J9

二甲基姜黄素,GO-Y025; Dimethylcurcumin; ASC J9; GO Y025
A selective enhancer of AR degradation
GC31762 Asimadoline (EMD-61753)

阿西马朵林; EMD-61753
A potent κ-opioid receptor agonist
GC61397 Asimadoline hydrochloride

阿西马朵林盐酸盐; EMD-61753 hydrochloride
A potent κ-opioid receptor agonist
GC46892 ATRA-BA Hybrid A prodrug form of all-trans retinoic acid and butyric acid
GC66207 Atraric acid

Methyl atrarate
Atraric acid (Methyl atrarate) 是一种特异的雄激素受体 (androgen receptor) 拮抗剂，具有抗炎和抗癌作用。Atraric acid 抑制 LNCaP 和 C4-2 细胞中内源性前列腺特异性抗原基因的表达。Atraric acid 还能抑制 NO 和细胞因子的合成，抑制 MAPK-NFκB 信号通路。Atraric acid 可用于前列腺疾病和炎症性疾病的研究。
GC42870 Atrazine Mercapturate

阿特拉津代谢物
A metabolite of atrazine
GC49321 AZ-GHS-22 An inverse agonist of GHS-R1a
GC32801 AZ876

2-叔丁基-5-苯基-4-[[4-(1-哌啶基)苯基]氨基]-3(2H)-异噻唑啉酮1,1-二氧化物
An LXR agonist
GC12434 AZD1981 A DP₂/CRTH₂ receptor antagonist