Endocrinology and Hormones(内分泌和激素)

Endocrinology and Hormones

The endocrine system is an information signaling system that coordinates most bodily functions. It senses environmental changes and secretes corresponding hormones to coordinate metabolism, maintain homeostasis, and regulate growth and development.read more

Products for Endocrinology and Hormones

Cat.No. 产品名称 Information
GC42954 BMS 470539 (hydrochloride) BMS 470539 (hydrochloride)是一种高效的选择性黑皮质素1受体（MC-1R）激动剂，在cAMP积累测定中，对人源和鼠源MC1R的EC₅₀值分别为16.8和11.6nM。
GC42943 Bischloroanthrabenzoxocinone
BABX, (―)-Bischloroanthrabenzoxocinone
An inhibitor of FAS-II
GC42870 Atrazine Mercapturate
阿特拉津代谢物
A metabolite of atrazine
GC42852 Arginine Vasotocin (trifluoroacetate salt)
Arg8-Vasotocin, AVT
A nonapeptide agonist of the AVT receptor
GC42815 Ansatrienin A
安三烯菌素A
An ansamycin antibiotic and antifungal
GC42797 Amylin (rat, mouse) (trifluoroacetate salt)
IAPP (rat, mouse), Islet Amyloid Polypeptide (rat, mouse)
A peptide hormone
GC42795 Amylin (human) (amidated) (trifluoroacetate salt)
IAPP (human) (amidated), Islet Amyloid Polypeptide (human) (amidated)
A peptide hormone
GC42793 Amylin (1-13) (human, mouse, rat), (trifluoroacetate salt)
IAPP (1-13) (human, mouse rat), Islet Amyloid Polypeptide (1-13) (human. mouse, rat)
A peptide fragment of amylin
GC42769 all-trans Retinoyl β-D-Glucuronide
(E-视黄酰基)-Β-葡糖苷酸
A metabolite of all-trans retinoic acid
GC42741 Adrenomedullin (22-52) (human) (trifluoroacetate salt) A C-terminal fragment of adrenomedullin
GC42569 5α-Androst-16-en-3-one
雄烯酮
A mammalian pheromone
GC42473 4-tert-Octylphenol diethoxylate
2-[2-[4-(1,1,3,3-四甲基丁基)苯氧基]乙氧基]-乙醇
An endocrine disruptor
GC42294 3-Iodothyronamine (hydrochloride)
T1AM
A metabolite of thyroxine
GC41950 16α-hydroxy Estrone
16ALPHA-羟基雌酚酮,16αOHE
A hydroxylated metabolite of estrone
GC41745 [Nle4,D-Phe7]-α-MSH (trifluoroacetate salt) A synthetic analog of α-MSH
GC41699 (Des-octanoyl)-Ghrelin (human) (trifluoroacetate salt) A peptide hormone
GC41671 (±)-Equol 4'-sulfate (sodium salt)
R,S-Equol 4'-Sulfate
A metabolite of (±)-equol
GC41321 17α,20β-Dihydroxy-4-pregnen-3-one
4-孕烷-17Α,20Β-二醇-3-酮,17α,20β-DHP，17α,20β-dihydroxy Progesterone
17α,20β-dihydroxy-4-pregnen-3-one被确认为是包括鲑科鱼类在内的多种鱼类的成熟诱导激素。
GC41300 17β-hydroxy Exemestane
亚甲基宝丹酮
An active metabolite of exemestane
GC41266 Pregnanediol-3-Glucuronide
Pregnanediol-3α-Glucuronide
A metabolite of progesterone
GC41153 Tibolone
替勃龙
Tibolone是一种合成类固醇，具有弱雌激素、孕激素及雄激素活性。
GC40968 21-hydroxy Eplerenone
21-羟基依普利酮
A major metabolite of eplerenone
GC40960 20α-dihydro Prednisolone
20(R)-羟基泼尼松龙
A metabolite of prednisolone
GC40911 Glycine-β-muricholic Acid
Gly-MCA, GβMCA
Glycine-β-muricholic Acid是一种有效的、稳定的、对精氨酸有选择性的口服生物活性FXR抑制剂，是鼠特异性初级胆汁酸β-鼠胆酸的甘氨酸结合形式。
GC40867 Diflorasone Diacetate
醋酸双氟拉松；二醋酸二氟拉松
A corticosteroid
GC40833 (E/Z)-Endoxifen
N-去甲基-4-羟基-
An active metabolite of tamoxifen
GC40571 24(S),25-epoxy Cholesterol
(24S)-24,25-环氧胆固醇,24(S)-24,25-EC
An oxysterol
GC40528 11α-hydroxy Testosterone A CYP3A metabolite of testosterone
GC40465 9(S)-HETE
9(S)-Hydroxyeicosatetraenoic Acid
A monohydroxy fatty acid and RXRγ agonist
GC40464 9(R)-HETE
9(R)-Hydroxyeicosatetraenoic Acid
Enantiomer of (±)9-HETE; RXRγ activator
GC40454 16(S)-HETE
16(S)-Hydroxyeicosatetraenoic Acid
A potent inhibitor of proximal tubule ATPase activity
GC40341 Tetrahydro-11-deoxy Cortisol
四氢化-11-脱氧皮质醇
A metabolite of 11-deoxycortisol
GC40301 Tamoxifen N-oxide
他莫昔芬N-氧化物
A metabolite of tamoxifen
GC40293 Z3-Dodecenyl E2-butenoate A synthetic female sex pheromone
GC34887 Androstanolone acetate
雄诺龙醋酸酯
Androstanoloneacetate是一种雄激素配体，靶向作用于雄激素受体α(AR)。Androstanoloneacetate通过连接桥与cIAP1配体Bestatin结合从而形成PROTAC分子。
GC34862 WYC-209
4,5-二(羟甲基)-2-苯基-1H-咪唑
WYC-209是一种合成类视黄醇，能抑制恶性小鼠黑色素瘤肿瘤再生细胞(TRC)的增殖，IC50值为0.19μM。WYC-209主要细胞靶点是维甲酸受体(RARs)。
GC34824 T4-ATA S-isomer T4-ATAS-isomer是T4-ATA的S-异构体，是甲状腺激素的活性形式。
GC34822 T3-ATA S-isomer T3-ATAS-isomer是T3-ATA的S-异构体，是甲状腺激素的活性形式。
GC34740 PROTAC RAR Degrader-1 PROTACRARDegrader-1包含cIAP1配体结合基团，linker和RAR配体结合基团。在HT1080细胞中，PROTACRARDegrader-1降低RAR水平，30μM浓度时达到最大降解程度。同时，基于cIAP1的降解剂也被称为SNIPER。
GC34686 Nidufexor
LMB763

An FXR partial agonist
GP21262 Goserelin
Goserelin (ICI 118630) 是促性腺激素释放激素 (GnRH/LHRH) 的十肽类似物，可作为 GnRH 激动剂发挥作用。
GC19500 LY2795050 A κ-opioid receptor antagonist
GC40241 Fulvestrant-d3
ICI 182780-d3; ZD 9238-d3; ZM 182780-d3
An internal standard for the quantification of fulvestrant
GC40109 Ketoconazole-d3
2,2,2-三氮杂-1--1-[4-[4-[[（（2R，4S）-2-（2,4-二氯苯基）-2-（咪唑-1-基甲基）-1,3-二氧戊环-4-基]甲氧基]苯基]哌嗪-1-基]乙酮,(-)-Ketoconazol-d3; (-)-R 41400-d3
An internal standard for the quantification of ketoconazole
GC40094 all-trans Retinoic Acid-d5
atRA-d5, RA-d5, Vitamin A Acid-d5
An internal standard for the quantification of all-trans retinoic acid
GC40053 5α,6α-epoxy Cholestanol
胆固醇-5Α,6Α-环氧化物,NSC 18176
5α,6α-epoxy Cholestanol 是一种胆固醇衍生物，可以通过线粒体中的细胞色素P450酶系催化生成或是在脂质过氧化过程中诱导生成，可调节胆汁酸的生物合成、诱导肿瘤细胞的分化和死亡。
GC40049 Glucocorticoid Resistance Inhibitor An inhibitor of glucocorticoid resistance
GC40024 Altenusin
细格菌素,Alutenusin
A fungal metabolite with diverse biological activities
GC34223 Dermorphin Analog DermorphinAnalog是Dermorphin的类似物。Dermorphin为两栖类皮肤中发现的天然七肽，为μ-阿片受体(μ-opioidreceptor)激动剂。
GC34173 LG-100064
4-[(5,6,7,8-四氢-3,5,5,8,8-五甲基-2-萘基)羰基]苯甲酸
LG-100064是一种类视黄醇X受体(retinoid-X-receptor(RXR))激动剂，对RXRα，RXRβ和RXRγ的EC50值分别为330nM，200nM和260nM；LG-100064可用于癌症研究。