Ubiquitination/ Proteasome
Ubiquitination/ Proteasome(泛素化/蛋白酶体)
Ubiquitination/ Proteasome 相关产品(1292)
- GC351123'-HydroxypterostilbeneCAS: 475231-21-1纯度: >99.00%
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways.
- GC351324-HydroxylonchocarpinCAS: 56083-03-5
4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。
- GC35238Aclacinomycin A hydrochlorideCAS: 75443-99-1
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。
- GC35266AGN 196996CAS: 958295-17-5
AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。
- GC35322AmiodaroneCAS: 1951-25-3
Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias.
- GC35419AtorvastatinCAS: 134523-00-5纯度: >99.00% / >98.00% / >99.50%
阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂
- GC35433Autogramin-1CAS: 2375541-73-2纯度: >98.00%
Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。
- GC35434Autogramin-2CAS: 2375541-45-8纯度: >99.50%
Autogramin-2 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.27 μM。Autogramin-2 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.14 μM。
- GC35445AzathramycinCAS: 76801-85-9纯度: >98.00%
Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose.
- GC35497Berberine chloride hydrateCAS: 68030-18-2纯度: >99.50% / >99.00%
As isoquinoline alkaloid with diverse biological activities
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC34924 | NSC 185058 | 39122-38-8 | >98.00% | |
NSC 185058是一种ATG4B的合成抑制剂，IC 50 值为51μM。 | ||||
| GC34960 | (+)-Talarozole | 201410-66-4 | >99.50% | |
(+)-Talarozole 是视黄酸代谢的有效抑制剂，来自专利 WO 1997049704 A1。 | ||||
| GC35068 | 1-Monomyristin | 589-68-4 | >98.00% | |
A monoacylglycerol | ||||
| GC35112 | 3'-Hydroxypterostilbene | 475231-21-1 | >99.00% | |
3'-Hydroxypterostilbene (3'-HPT) is one of the active constituents of Sphaerophysa salsula and Pterocarpus marsupium which may be useful in treating different types of haematological malignancies. 3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 3'-Hydroxypterostilbene inhibits the PI3K/Akt/mTOR/p70S6K, and p38MAPK pathways and activates the ERK1/2, JNK1/2 MAPK pathways. | ||||
| GC35132 | 4-Hydroxylonchocarpin | 56083-03-5 | - | |
4-Hydroxylonchocarpin 是一种查尔酮化合物，来自补骨脂 (Psoralea corylifolia) 提取物。4-Hydroxylonchocarpin 增强 p38 MAPK，JNK 和 ERK 的磷酸化。4-Hydroxylonchocarpin 具有多种药理活性，包括抗菌，抗癌，抗逆转录酶，抗结核，抗疟，抗炎和抗氧化活性。 | ||||
| GC35211 | A-317491 sodium salt hydrate | - | >99.50% | |
A P2X 3 and P2X 2/3 receptor antagonist | ||||
| GC35228 | Aceglutamide | 2490-97-3 | >98.00% | |
An acetylated form of L-glutamine | ||||
| GC35238 | Aclacinomycin A hydrochloride | 75443-99-1 | - | |
Aclacinomycin A hydrochloride (Aclarubicin hydrochloride) 是一种荧光分子，是第一个发现对 20S 蛋白酶体 (20S proteasome) 的CTRL (糜凝乳蛋白酶样) 活性具有离散特异性的非肽性抑制剂。 | ||||
| GC35242 | Actein | 18642-44-9 | >98.50% | |
Actein 是从 Cimicifuga foetida 的根茎中分离的三萜糖苷。Actein 通过促进 ROS/JNK 活化和钝化人膀胱癌中的 AKT 途径来抑制细胞增殖，诱导自噬和凋亡。Actein 在体内几乎没有毒性。 | ||||
| GC35262 | Afzelin | 482-39-3 | >98.00% | |
A polyphenolic glycoside flavone with diverse biological activities | ||||
| GC35265 | AGN 195183 | 367273-07-2 | >99.50% | |
AGN 195183是一种具有口服活性的维甲酸受体α（RARα）选择性激动剂。 | ||||
| GC35266 | AGN 196996 | 958295-17-5 | - | |
AGN 196996是高活性RARα选择性抑制剂，Ki为2 nM，对RARβ和RARγ的亲和性极低（Ki分别为1087 nM和8523 nM）。 | ||||
| GC35267 | AGN 205327 | 2070018-29-8 | - | |
AGN 205327是RAR激动剂，对RARα/β/γ的EC50分别为3766/734/32 nM，对RXR无抑制性。 | ||||
| GC35268 | AGN 205728 | 859498-05-8 | - | |
AGN 205728是选择性RARγ拮抗剂，Ki/IC95分别为3 nM/ 0.6 nM，对RARα和RARβ无抑制性。 | ||||
| GC35322 | Amiodarone | 1951-25-3 | - | |
Amiodarone (NSC 85442,Amiodar,Amiodarone hydrochloride,Nexterone) HCl is a sodium/potassium-ATPase inhibitor and an autophagy activator, used to treat various types of cardiac dysrhythmias. | ||||
| GC35419 | Atorvastatin | 134523-00-5 | >99.00% / >98.00% / >99.50% | |
阿托伐他汀（Atorvastatin）是一种口服活性HMG-CoA还原酶抑制剂，可以有效降低血脂 | ||||
| GC35432 | Autocamtide-2-related inhibitory peptide (TFA) | - | >95.00% | |
A CaMKII inhibitor | ||||
| GC35433 | Autogramin-1 | 2375541-73-2 | >98.00% | |
Autogramin-1 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.17 μM。Autogramin-1 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.44 μM。 | ||||
| GC35434 | Autogramin-2 | 2375541-45-8 | >99.50% | |
Autogramin-2 有效抑制由饥饿诱导的自噬 (autophagy)，IC50 为 0.27 μM。Autogramin-2 也抑制 Rapamycin (通过抑制 mTORC1) 诱导的自噬 (autophagy)，IC50 为 0.14 μM。 | ||||
| GC35445 | Azathramycin | 76801-85-9 | >98.00% | |
Azathramycin (Azaerythromycin A, Azaerythromycin) is a macrolide antibiotic containing cladinose. | ||||
| GC35462 | Bafetinib | 859212-16-1 | >99.50% | |
A Bcr-Abl inhibitor | ||||
| GC35497 | Berberine chloride hydrate | 68030-18-2 | >99.50% / >99.00% | |
As isoquinoline alkaloid with diverse biological activities | ||||
| GC35509 | BGT226 | 915020-55-2 | - | |
BGT226 (NVP-BGT226) maleate is a novel class I PI3K/mTOR inhibitor for PI3Kα/β/γ with IC50 of 4 nM/63 nM/38 nM. Phase 1/2. | ||||
| GC35554 | Brevilin A | 16503-32-5 | >98.00% | |
A sesquiterpene lactone with anticancer activity | ||||