Ubiquitination/ Proteasome
Ubiquitination/ Proteasome(泛素化/蛋白酶体)
Ubiquitination/ Proteasome 相关产品(1292)
- GC32998Ginsenoside Rh4CAS: 174721-08-5纯度: >98.00%
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways.
- GC33003Daurisoline ((R,R)-Daurisoline)CAS: 70553-76-3纯度: >99.50%
An alkaloid with diverse biological activities
- GC33004Cediranib maleate (AZD-2171 maleate)CAS: 857036-77-2纯度: >99.50%
An inhibitor of VEGF receptor tyrosine kinases
- GC33085Glaucocalyxin BCAS: 80508-81-2纯度: >99.00%
GlaucocalyxinB是从中药香茶菜中分离出来的对映-贝壳杉烷型二萜，具有抗癌和抗炎活性。24h内减少HL-60生长的IC50值约为5.86μM。
- GC33126LucanthoneCAS: 479-50-5纯度: >99.50%
Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1.
- GC33229SJFαCAS: 2254609-27-1
SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。
- GC33238SJFδCAS: 2254609-23-7
SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。
- GC33446Oxyphenisatin acetateCAS: 115-33-3纯度: >99.50%
Oxyphenisatinacetate是oxyphenisatin的前体药物，过去常用作泻药。
- GC33529Sulfabenzamide (N-Sulfanilylbenzamide)CAS: 127-71-9纯度: >99.50%
Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis.
- GC33683Autocamtide 2 (Autocamtide II)CAS: 129198-88-5纯度: >98.50%
Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。
- GC33715Fluoxetine (LY-110140)CAS: 54910-89-3纯度: >98.00%
氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。
- GC33743Alicapistat (ABT-957)CAS: 1254698-46-8纯度: >98.00%
Alicapistat (ABT-957) (ABT-957) 是一种口服有效的人类钙蛋白酶 1 和 2 选择性抑制剂，可用于治疗阿尔茨海默病's disease (AD)。
- GC33775Rimacalib (SMP 114)CAS: 215174-50-8纯度: >99.50%
Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC32901 | ROC-325 | 1859141-26-6 | >99.50% | |
An autophagy inhibitor | ||||
| GC32959 | Corynoxine | 6877-32-3 | >98.00% | |
An indole alkaloid | ||||
| GC32962 | QX77 | 1798331-92-6 | >98.00% | |
QX77是一种分子伴侣介导的自噬 (Chaperone-mediated autophagy, CMA) 激活剂。 | ||||
| GC32998 | Ginsenoside Rh4 | 174721-08-5 | >98.00% | |
Ginsenoside Rh4 is an important active ingredient of traditional Chinese medicine ginseng, which has been shown to inhibit Wnt/β-Catenin, JAK2/STAT3, TGF-β/Smad2/3 and other signaling pathways. | ||||
| GC33003 | Daurisoline ((R,R)-Daurisoline) | 70553-76-3 | >99.50% | |
An alkaloid with diverse biological activities | ||||
| GC33004 | Cediranib maleate (AZD-2171 maleate) | 857036-77-2 | >99.50% | |
An inhibitor of VEGF receptor tyrosine kinases | ||||
| GC33006 | CCT020312 | 324759-76-4 | >98.50% / >98.00% | |
CCT020312是一种选择性蛋白激酶R样内质网激酶（PERK）通路激动剂。 | ||||
| GC33008 | p38 MAPK-IN-1 | 1006378-90-0 | >99.50% | |
p38MAPK-IN-1是p38MAPK新型高效选择性抑制剂,IC50值68nM。 | ||||
| GC33085 | Glaucocalyxin B | 80508-81-2 | >99.00% | |
GlaucocalyxinB是从中药香茶菜中分离出来的对映-贝壳杉烷型二萜，具有抗癌和抗炎活性。24h内减少HL-60生长的IC50值约为5.86μM。 | ||||
| GC33126 | Lucanthone | 479-50-5 | >99.50% | |
Lucanthone is a novel autophagic inhibitor and also an orally available thioxanthone-based DNA intercalator and inhibitor of the DNA repair enzyme apurinic-apyrimidinic endonuclease 1. | ||||
| GC33218 | CA-5f | 1370032-19-1 | >99.00% | |
CA-5f 是一种有效的晚期巨自噬/自噬抑制剂，通过抑制自噬体-溶酶体融合。 CA-5f 增加 LC3B-II（一种监测自噬的标志物）和 SQSTM1 蛋白，并且还增加 ROS 的产生。抗肿瘤活性。 | ||||
| GC33229 | SJFα | 2254609-27-1 | - | |
SJFα是一种含13个原子连接桥的PROTAC。SJFα降解p38α，DC50为7.16nM，但降解p38δ效果较差(DC50=299nM)，且在浓度高达2.5μM时也不会降解其他p38亚型(β和γ)。 | ||||
| GC33238 | SJFδ | 2254609-23-7 | - | |
SJFδ是一种含10个原子连接桥的PROTAC。SJFδ降解p38α，DC50为46.17nM，但不降解其他p38亚型(p38α,p38β和p38γ)。 | ||||
| GC33311 | Proteasome-IN-1 | 374080-21-4 | - | |
Proteasome-IN-1是一个蛋白酶体抑制剂，来自专利WO2013142376A1。 | ||||
| GC33315 | AGN 194078 | 321995-62-4 | - | |
AGN194078是一个有选择性的RARα激动剂，其Kd和EC50值分别为3和112nM。 | ||||
| GC33377 | KSI-3716 | 1151813-61-4 | >98.50% | |
KSI-3716是c-Myc的抑制剂。 | ||||
| GC33446 | Oxyphenisatin acetate | 115-33-3 | >99.50% | |
Oxyphenisatinacetate是oxyphenisatin的前体药物，过去常用作泻药。 | ||||
| GC33464 | Oxyresveratrol (trans-Oxyresveratrol) | 29700-22-9 | >98.50% | |
A resveratrol analog | ||||
| GC33529 | Sulfabenzamide (N-Sulfanilylbenzamide) | 127-71-9 | >99.50% | |
Sulfabenzamide (Sultrin, N-Sulfanilylbenzamide) is an antibacterial/antimicrobial which also exhibit their antitumor effects through multiple mechanisms including inhibition of membrane bound carbonic anhydrases, prevention of microtubule assembly, cell cycle arrest, and inhibition of angiogenesis. | ||||
| GC33683 | Autocamtide 2 (Autocamtide II) | 129198-88-5 | >98.50% | |
Autocamtide 2 (Autocamtide II) 是钙/钙调蛋白依赖性蛋白激酶 II (CaMKII) 的高选择性肽底物。 | ||||
| GC33715 | Fluoxetine (LY-110140) | 54910-89-3 | >98.00% | |
氟西汀Fluoxetine (LY-110140)是一种具有口服活性的选择性5-羟色胺再摄取抑制剂（SSRI），常用于治疗抑郁症、强迫症、恐慌症等多种精神疾病。 | ||||
| GC33732 | Syntide 2 | 108334-68-5 | - | |
A protein kinase substrate | ||||
| GC33743 | Alicapistat (ABT-957) | 1254698-46-8 | >98.00% | |
Alicapistat (ABT-957) (ABT-957) 是一种口服有效的人类钙蛋白酶 1 和 2 选择性抑制剂，可用于治疗阿尔茨海默病's disease (AD)。 | ||||
| GC33775 | Rimacalib (SMP 114) | 215174-50-8 | >99.50% | |
Rimacalib (SMP 114) (SMP 114) 是一种 Ca2+/钙调蛋白依赖性蛋白激酶 II (CaMKII) 抑制剂，IC50 为 ~1 μ；M 代表 CaMKIIα；至 ~30 μ；M 代表 CaMKIIγ；。 | ||||