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Home >> Signaling Pathways >> Ubiquitination/ Proteasome

Ubiquitination/ Proteasome(泛素化/蛋白酶体)

Cat.No. 产品名称 Information
GC19237 Lys01 trihydrochloride
Lys01 trihydrochloride
An inhibitor of autophagy
GC19236 LYN-1604 A ULK1 activator
GC19232 LY2955303 A potent RARγ antagonist
GC19188 HA15 HA15是一种特异性靶向BiP/GRP78/HSPA5的分子，可结合并抑制其ATPase活性，导致BiP与PERK、IRE1α和ATF6分离，从而引发内质网应激。
GC19169 GLPG1837
ABBV-974
A CFTR potentiator
GC19083 Briciclib
ON 014185
An eIF4E inhibitor
GC19040 AS1842856
5-氨基-7-(环己基氨基)-1-乙基-6-氟-1,4-二氢-4-氧代-3-喹啉羧酸
AS1842856是一种细胞渗透性抑制剂,抑制Foxo1转录活性,IC50=33 nM。
GC19035 AR7 AR7是一种非典型视黄酸受体α（RARα）拮抗剂。
GC19019 Acumapimod
BCT197
An inhibitor of p38α MAPK
GC18487 BC-1215 An inhibitor of FBXO3
GC18304 Bicyclol
双环醇; SY801
A hepatoprotective agent
GC18269 SR 18292 SR 18292是一种过氧化物酶体增殖物激活受体γ（PPARγ）共激活因子-1α（PGC-1α）的抑制剂，可促进PGC-1α乙酰化，抑制糖异生基因的表达，并减少肝细胞中葡萄糖的产生。
GC18212 Cilofexor
GS-9674
An FXR ligand
GC18174 BIA 10-2474
3-(1-(环己基(甲基氨基甲酰基)-1H-咪唑-4-基)吡啶1-氧化物
An inhibitor of FAAH
GC15168 Urolithin A
尿石素A
Urolithin A是由鞣花酸和鞣花单宁代谢产生的一种活性成分，可作为酪氨酸酶（IC₅₀值为71.44±10.07µmol/L）和单胺氧化酶A（IC₅₀值为29.41±9.01µmol/L）的强效抑制剂。
GC14820 (S)-Naproxen
萘普生; (S)-Naproxen
An NSAID and COX inhibitor
GC14918 10074-G5
N-2-联苯基-7-硝基-2,1,3-苯并恶二唑-4-胺
An inhibitor of c-Myc/Max dimerization
GC17768 Lasalocid
那塞罗; Lasalocid-A; Ionophore X-537A; Antibiotic X-537A
An ionophore antibiotic
GC13063 N-Benzylpalmitamide
N-苄基棕榈酰胺,N-Benzylhexadecanamide
A long-chain fatty acid amide
GC10593 BMS-582949 hydrochloride A p38α MAP kinase inhibitor
GC14749 ALLO-1 A smoothened antagonist
GC11989 Nortriptyline (hydrochloride)
盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride
A tricyclic antidepressant
GC10133 JNJ-42165279
N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺
An irreversible FAAH inhibitor
GC16699 HMB-Val-Ser-Leu-VE A vinyl ester tripeptide inhibitor of proteasome trypsin-like activity
GC13311 Triclosan
三氯生
Triclosan 是一种广谱抗菌剂。
GC10331 Ebselen
依布硒; SPI-1005; PZ-51; CCG-39161
Ebselen一种具有谷胱甘肽过氧化物酶样活性的硒代有机化合物，是一种抗炎和抗氧化剂。Ebselen是肌醇单磷酸酶（IMPase）的抑制剂，IC₅₀为1.5μM。
GC12235 Sitagliptin (phosphate)
磷酸西他列汀; MK-0431 phosphate
A DPP-4 inhibitor
GC14591 Hemin chloride
氯化血红素; Hemin chloride
氯化血红素是血红素加氧酶(HO)-1的底物，可诱导多种细胞表达HO-1，发挥抗氧化和抗炎作用。
GC17912 C598-0466
USP7 inhibitor
GC10601 Ubiquitin Isopeptidase Inhibitor I
NSC 144303
An activator of caspases
GC14413 KJ Pyr 9 An inhibitor of c-Myc and v-Myc interaction with Max
GC15814 Pamapimod (R-1503, Ro4402257)
Ro4402257; R1503
An orally bioavailable inhibitor of p38α MAP kinase
GC10436 VPS34-IN1
Vacuolar Protein Sorting 34 Inhibitor 1, Vps34 Inhibitor 1
A potent and selective inhibitor of Vps34
GC14086 MRT68921 MRT68921是一种强效的ULK1和ULK2双重抑制剂，对ULK1和ULK2的IC₅₀值分别为2.9nM和1.1nM。
GC14679 PIK-III
Vacuolar Protein Sorting 34 Inhibitor 2, Vps34-IN2, Vps34 Inhibitor 2
A selective inhibitor of Vps34
GC11365 Nitroxoline
硝羟喹啉; 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol
An 8-hydroxyquinoline with diverse biological activities
GC11567 Acetazolamide
乙酰唑胺
An Analytical Reference Standard
GC13656 ML241 hydrochloride ML241 hydrochloride 是一种有效的 p97 抑制剂，抑制 p97 ATPase，IC50 值为 100 nM。
GC17310 SR9011 A REV-ERBα/β agonist
GC12035 SR9009
REV-ERB Agonist II

SR9009 是一种合成的 REV-ERB 激动剂，用于治疗肥胖、躁郁症、焦虑症和抑郁症等代谢性疾病。
GC11749 ML241 p97 ATPase inhibitor
GC13915 Tizoxanide
替唑尼特; TIZ
An active metabolite of nitazoxanide
GC14371 LY3023414
LY3023414
LY3023414 (LY3023414) potently and selectively inhibits class I PI3K isoforms, DNA-PK, and mTORC1/2 with IC50s of 6.07 nM, 77.6 nM, 38 nM, 23.8 nM, 4.24 nM and 165 nM for PI3Kα, PI3Kβ, PI3Kδ , PI3Kγ, DNA-PK 和 mTOR, 分别。 LY3023414 在低纳摩尔浓度下有效抑制 mTORC1/2。
GC13554 Deferoxamine mesylate
甲磺酸去铁胺; Desferrioxamine B mesylate; DFOM
Deferoxamine mesylate 是一种通过形成稳定的复合物来螯合铁的药物，该复合物可防止铁进入进一步的化学反应，并用于治疗输血依赖性贫血患者的慢性铁过载。
GC16351 CB-5083
CB-5083是一种具有高效选择性和口服活性的AAA-ATPase p97抑制剂，IC₅₀值为11nM。
GC12003 VR23 A proteasome inhibitor
GC11857 Pexmetinib (ARRY-614)
ARRY-614
A dual inhibitor of Tie2 and p38 MAPK
GC11031 PX-478 2HCl PX-478是一种选择性抑制剂，可以抑制常规和低氧诱导的HIF-1α水平。
GC17975 Naproxen Sodium
萘普生钠
Naproxen sodium 是一种 COX-1 和 COX-2 抑制剂，在细胞试验中 IC50 分别为 8.72 和 5.15 μM。
GC13442 Sanguinarine chloride
氯化血根碱; Sanguinarin chloride; Sanguinarium chloride; Pseudochelerythrine chloride
A natural alkaloid with anti-inflammatory and anti-oxidant properties