GlpBio

Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Endogenous Metabolite 相关产品(1712)

  • GC38834 structure
    GC38834Phosphonoacetic acid
    CAS: 4408-78-0
    纯度: >98.00%

    Phosphonoacetic acid (PAA) is an active endogenous metabolite that possesses a restricted potential to block DNA biosynthesis. Phosphonoacetic acid exhibits anti-viral activities.

  • GC38859 structure
    GC38859Tetrahydrocortisone
    CAS: 53-05-4
    纯度: >98.00%

    A metabolite of cortisol

  • GC38882 structure
    GC388825-ALA benzyl ester hydrochloride
    CAS: 163271-32-7
    纯度: >97.50%

    5-ALA benzyl ester hydrochloride (Benzyl-ALA hydrochloride) 是一种用作光检测器的原卟啉前体。5-ALA benzyl ester hydrochloride 诱导原卟啉 IX (PPIX) 在结肠癌细胞系中的积聚。

  • GC38883 structure
    GC388839-Ethyladenine
    CAS: 2715-68-6

    9-Ethyladenine 是 APRT (腺嘌呤磷酸核糖基转移酶) 的部分有效抑制剂。

  • GC38885 structure
    GC38885alpha-D-glucose
    CAS: 492-62-6
    纯度: >99.00%

    Alpha-D-Glucose is a primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is an intermediate in glycolysis/gluconeogenesis pathway.

  • GC38920 structure
    GC38920L-Carnitine hydrochloride
    CAS: 6645-46-1
    纯度: >98.00%

    L-Carnitine ((R)-Carnitine, Levocarnitine) hydrochloride improves oxygen saturation, and inhibits leukotriene synthesis. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation.

  • GC38958 structure
    GC38958Sorbic acid
    CAS: 110-44-1
    纯度: >99.50%

    Sorbic acid (2,4-Hexadienoic acid) is a naturally occurring compound that originated from the unripe berries of the Rowan Tree. It inhibits various bacteria, including sporeformers, at various stages of their life cycle (germination, outgrowth and cell division).

  • GC39115 structure
    GC39115Terpinen-4-ol
    CAS: 562-74-3

    Terpinen-4-ol, a naturally occurring monoterpene, is the main bioactive component of tea-tree oil and has been shown to have many biological activities such as antifungal properties.

  • GC39119 structure
    GC39119Isonicotinic acid
    CAS: 55-22-1
    纯度: >98.00%

    Isonicotinic acid (Isoniazid, 4-pyridinecarboxylic acid, p-pyridinecarboxylic acid, 4-Picolinic acid) is a metabolite of isoniazid. It is an isomer of nicotinic acid.

  • GC39173 structure
    GC39173Phosphorylcholine chloride calcium salt tetrahydrate
    CAS: 72556-74-2

    Phosphocholine (Phosphorylcholine) chloride calcium salt tetrahydrate is an active endogenous metabolite.

  • GC39185 structure
    GC39185Pregnanediol
    CAS: 80-92-2
    纯度: >95.00% / >98.00%

    Pregnanediol是孕酮的主要代谢产物，通过尿液排出体外。

  • GC39199 structure
    GC39199Thymopentin acetate
    CAS: 89318-88-7
    纯度: >99.50%

    A pentapeptide fragment of thymopoietin

  • GC39223 structure
    GC3922311-Beta-hydroxyandrostenedione
    CAS: 382-44-5
    纯度: >98.50%

    11β-Hydroxyandrostenedione是一种内源性、天然存在的?类固醇和雄激素原，主要（如果不是完全）在肾上腺中产生。它与肾上腺产生的肾上腺素(11-ketoandrostenedione; 11-KA4)、11-ketotestosterone?(11-KT) 和11-ketodihydrotestosterone?(11-KDHT)密切相关。可用作指导肾上腺静脉取样中原发性醛固酮增多症亚型的生物标志物，其中从两个肾上腺采集血样以比较每个腺体产生的激素量。

  • GC39271 structure
    GC39271(±)-Naringenin
    CAS: 67604-48-2
    纯度: >98.50%

    A citrus- derived flavonoid

  • GC39306 structure
    GC39306D-Glucose 6-phosphate disodium salt
    CAS: 3671-99-6

    D-Glucose-6-phosphate disodium salt 称 6-磷酸葡萄糖，是葡萄糖经过磷酸化 (在第 6 号碳) 之后生成的分子。它是生物细胞中的常见分子，参与磷酸戊糖途径与糖酵解等生化途径。

  • GC39363 structure
    GC39363Cortodoxone
    CAS: 152-58-9
    纯度: >98.00% / >99.50%

    Cortodoxone (11-Deoxycortisol, cortexolone, 11-Desoxycortisol, 17α,21-dihydroxyprogesterone), also known as 11-Deoxycortisol, is a glucocorticoid steroid hormone.

  • GC39366 structure
    GC39366Creatinine-D3
    CAS: 143827-20-7
    纯度: >99.50% / >98.00%

    Creatinine-D3是一种氘标记的肌酸酐化合物。

  • GC39368 structure
    GC39368Dacisteine
    CAS: 18725-37-6
    纯度: >99.00%

    Dacisteine (N,S-Diacetyl-L-cysteine) 是一种半胱氨酸衍生物，具有很小的 (NDM-1) 抑制活性，IC50 值为 1000 μM。Dacisteine 可用于治疗血小板聚集引起的心脑血管疾病。

  • GC39418 structure
    GC39418p-Anisic acid
    CAS: 100-09-4
    纯度: >99.50%

    p-Anisic acid (4-Methoxybenzoic acid) 是anisic acid 的一个异构体，具有抗菌和防腐活性。

  • GC39424 structure
    GC39424Propofol
    CAS: 2078-54-8
    纯度: >99.50%

    Propofol是一种广泛用于麻醉诱导和维持的静脉麻醉药，具有调节自噬、抗肿瘤或致癌活性。

  • GC39427 structure
    GC39427p-Toluic acid
    CAS: 99-94-5
    纯度: >99.50%

    p-Toluic acid (4-Methylbenzoic acid) 是一种被取代的苯甲酸，是合成对氨基甲基苯甲酸 (PAMBA)，对甲苯腈等的中间体。

  • GC39470 structure
    GC394701-Octanol
    CAS: 111-87-5
    纯度: >98.00%

    1-辛醇是一种脂肪醇。用于合成用于香水和调味剂的酯，有刺激性气味。?辛醇酯，例如乙酸辛酯，作为精油的成分存在。用于评价药品的亲脂性。是一种T型钙通道抑制剂

  • GC39473 structure
    GC394734-Bromo-3-hydroxybenzoic acid
    CAS: 14348-38-0
    纯度: >99.50%

    4-Bromo-3-hydroxybenzoic acid 是一种 Brocresine 的代谢产物，也是一种组氨酸脱羧酶 (HDC) 抑制剂，对大鼠胎儿和大鼠胃 HDC 的 IC50 均为 1 mM。4-Bromo-3-hydroxybenzoic acid 还可以在体外抑制猪肾脏和大鼠胃粘膜中的芳香族 L-氨基酸脱羧酶 (aromatic-L-amino acid decarboxylase)，两种酶的 IC50 均为 1 mM。

  • GC39474 structure
    GC394747-Ketolithocholic acid
    CAS: 4651-67-6
    纯度: >98.00%

    7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid)是一种胆汁酸，7-Ketolithocholic acid可被吸收，7-ketolithocholic acid抑制内源性胆汁酸的产生，并可影响分泌胆汁胆固醇。