7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid) is a kind of bile acid, 7-Ketolithocholic acid can be absorbed, 7-ketolithocholic acid inhibits the production of endogenous bile acid, and can affect the secretion of biliary cholesterol[1，2].
After 7-ketolithocholic acid (400 mg/day) was administered orally for 14 days, biliary bile acid composition changed: The proportion of cholic acid decreased (from 45% to 19%), deoxycholic acid decreased (from 15% to 10%), chenodeoxycholic acid increased markedly (from 36% to 59%), ursodeoxycholic acid increased (from 36% to 59%), ursodeoxycholic acid increased (from 2% to 7%), and lithocholic acid increased (from 2% to 5%), while only trace amounts of 7-ketolithocholic acid were detected. During this treatment, the biliary lithogenic index fell from 2.6 to 0.9 and was accompanied by a pronounced drop in biliary cholesterol concentration[2].
References:
[1]. Choucair I, Nemet I, et,al. Quantification of bile acids: a mass spectrometry platform for studying gut microbe connection to metabolic diseases. J Lipid Res. 2020 Feb;61(2):159-177. doi: 10.1194/jlr.RA119000311. Epub 2019 Dec 9. PMID: 31818878; PMCID: PMC6997600.
[2]. Salen G, Verga D, et,al. Effect of 7-ketolithocholic acid on bile acid metabolism in humans. Gastroenterology. 1982 Aug;83(2):341-7. PMID: 7084613.
7-Ketolithocholic acid (3α-hydroxy-7-oxygen-5β-cholic acid)是一种胆汁酸，7-Ketolithocholic acid可被人体吸收，7-ketolithocholic acid抑制内源性胆汁酸的产生，可影响胆汁胆固醇的分泌[1，2]。
口服 7-酮石胆酸（400 毫克/天）14 天后，胆汁酸成分发生变化:胆酸比例下降（从 45% 下降到 19%），脱氧胆酸下降（从 15% 下降到10%），鹅去氧胆酸显着增加（从 36% 到 59%），熊去氧胆酸增加（从 36% 到 59%），熊去氧胆酸增加（从 2% 到 7%），石胆酸增加（从 2% 到5%), 而仅检测到痕量的 7-酮石胆酸。在此治疗期间，胆道结石指数从 2.6 降至 0.9，并伴随着胆道胆固醇浓度的显着下降[2]。