GlpBio

TNF-α

TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

TNF-α 相关产品(145)

  • GC11008 structure
    GC11008Necrostatin-1
    CAS: 4311-88-0
    纯度: >98.00% / >99.00%

    Necrostatin-1主要作用于细胞中的RIP1，Necrostatin-1是一种RIP1激酶抑制剂，IC50值为0.32 mM。

  • GC11697 structure
    GC11697Pomalidomide (CC-4047)
    CAS: 19171-19-8
    纯度: >99.50%

    An inhibitor of cereblon

  • GC14976 structure
    GC14976Lenalidomide (CC-5013)
    CAS: 191732-72-6
    纯度: >99.50%

    Lenalidomide (CC-5013)是thalidomide的4-氨基-谷氨酰类似物，具有更强的效力，且不具有thalidomide相关的镇静和神经病变等神经系统副作用。

  • GC10350 structure
    GC10350TIC10 isomer
    CAS: 41276-02-2
    纯度: >98.00%

    TIC10 isomer是TIC10/ONC201的类似物。

  • GC10420 structure
    GC10420Apremilast (CC-10004)
    CAS: 608141-41-9
    纯度: >99.50%

    An orally available PDE4 inhibitor

  • GC11659 structure
    GC11659R-7050
    CAS: 303997-35-5
    纯度: >99.00%

    R-7050 是一种新型细胞渗透性三唑并喹喔啉化合物，可选择性抑制 TNF-α；诱导细胞信号传导。

  • GC11751 structure
    GC11751QNZ (EVP4593)
    CAS: 545380-34-5
    纯度: >98.00%

    QNZ (EVP4593)是一种高效、选择性核因子κB（NF-κB）信号通路抑制剂，IC 50 值为11nM，具有抗炎功效。

  • GC12045 structure
    GC12045LY 303511
    CAS: 154447-38-8

    An inhibitor of cell proliferation

  • GC14500 structure
    GC14500CPI-1189
    CAS: 183619-38-7

    A benzamide

  • GC15573 structure
    GC15573GSK481
    CAS: 1622849-58-4
    纯度: >98.00%

    A selective inhibitor of RIP1

  • GC16007 structure
    GC16007Methylthiouracil
    CAS: 56-04-2
    纯度: >98.00%

    甲基硫氧嘧啶是一种抗甲状腺药物。

  • GC16673 structure
    GC16673N-Formyl-Met-Leu-Phe
    CAS: 59880-97-6
    纯度: >99.50%

    N-Formyl-Met-Leu-Phe是一种内源性趋化肽，也是甲酰肽受体1（FPR1）的激动剂，Ki值为38 nM。

  • GC17054 structure
    GC17054Thalidomide
    CAS: 50-35-1
    纯度: >99.50%

    Thalidomide是一种非成瘾性、非巴比妥类镇静剂，可抑制cereblon蛋白，具有抗炎和抗血管生成特性。

  • GC17632 structure
    GC17632Maslinic Acid
    CAS: 4373-41-5
    纯度: >98.00%

    Maslinic Acid是一种五环三萜酸，广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性。

  • GC18392 structure
    GC18392Cellocidin
    CAS: 543-21-5

    An antibiotic

  • GC18796 structure
    GC18796Herbicidin A
    CAS: 55353-31-6
    纯度: >98.00%

    An adenine nucleoside antibiotic with herbicidal activity

  • GC19046 structure
    GC19046AX-024 hydrochloride
    CAS: 1704801-24-0
    纯度: >99.00%

    An inhibitor of the CD3ε-Nck interaction

  • GC19533 structure
    GC19533Infliximab
    CAS: 170277-31-3
    纯度: >98.00% / >98.50%

    英夫利昔单抗是一种嵌合单克隆 IgG1 抗体，可特异性结合 TNF-α。

  • GC30910 structure
    GC30910Eucalyptol (1,8-Cineole)
    CAS: 470-82-6

    Eucalyptol是5-HT3受体,钾通道,TNF-α和IL-1β的抑制剂。

  • GC31692 structure
    GC31692Homoplantaginin
    CAS: 17680-84-1
    纯度: >99.50%

    A flavonoid glycoside with antioxidant and anti-inflammatory activities

  • GC31739 structure
    GC31739Hispidol ((Z)-Hispidol)
    CAS: 5786-54-9
    纯度: >99.50%

    Hispidol ((Z)-Hispidol) ((Z)-Hispidol ((Z)-Hispidol)) 是炎症性肠病的潜在治疗剂；抑制 TNF-α；诱导单核细胞与结肠上皮细胞的粘附，IC50 为 0.50 μM.

  • GC33133 structure
    GC33133SPD304
    CAS: 869998-49-2
    纯度: >98.00%

    SPD304是一种选择性的肿瘤坏死因子α（TNF-α）抑制剂，IC 50 值为22μM。

  • GC33330 structure
    GC33330Cynaropicrin
    CAS: 35730-78-0
    纯度: >98.00%

    A sesquiterpene lactone

  • GC33337 structure
    GC33337CDC801
    CAS: 192819-27-5

    CDC801是一种强效的磷酸二酯酶4(PDE4)和肿瘤坏死因子-α(TNF-α)抑制剂。IC50分别为1.1μM和2.5μM。