TIC10 isomer is the analogue of TIC10/ONC201[1]. The TIC10 isomer can be used as a model compound to analyze the active structure and optimize the production route of TIC10[2]. TIC10 isomer can be used as an internal reference to develop new nuclear magnetic resonance (NMR) methods for characterizing related compounds[3].
References:
[1] Greer Y E, Lipkowitz S. TIC10/ONC201: a bend in the road to clinical development[J]. Oncoscience, 2015, 2(2): 75.
[2] Jacob N T, Lockner J W, Kravchenko V V, et al. Pharmacophore reassignment for induction of the immunosurveillance cytokine TRAIL[J]. Angewandte Chemie, 2014, 126(26): 6746-6749.
[3] Oguadinma P, Bilodeau F, LaPlante S R. NMR strategies to support medicinal chemistry workflows for primary structure determination[J]. Bioorganic & medicinal chemistry letters, 2017, 27(2): 242-247.
TIC10 isomer是TIC10/ONC201的类似物[1]。TIC10 isomer可作为模型化合物用于分析TIC10的活性结构及优化其合成路线[2]。TIC10 isomer能作为内参物用于开发新型核磁共振（NMR）方法以表征相关化合物[3]。