TNF-α
TNF-α(肿瘤坏死因子-α)
Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.
TNF-α 相关产品(145)
- GC44388NF-κB ControlCAS: 201608-17-5纯度: >95.00%
A negative control peptide used with NF-κB inhibitor
- GC46862Apigenin-d5CAS: 263711-74-6纯度: >99.00%
An internal standard for the quantification of apigenin
- GC47544Lauric Acid-13CCAS: 93639-08-8纯度: >95.00%
An internal standard for the quantification of lauric acid
- GC48195trans-trismethoxy Resveratrol-d4CAS: 1089051-64-8纯度: >99.00%
An internal standard for the quantification of trans-trismethoxy resveratrol
- GC48202Treprostinil (diethanolamine salt)CAS: 830354-48-8纯度: >98.00%
An agonist of IP 2 , DP 2 , and EP 2 receptors
- GC48292α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt)CAS: 171869-93-5纯度: >98.00%
A peptide hormone
- GC48827Flufenamic Acid-d4CAS: 1185071-99-1纯度: >99.00%
An internal standard for the quantification of flufenamic acid
- GC48907Metaxalone-d6CAS: 1189944-95-3纯度: >99.00%
An internal standard for the quantification of metaxalone
- GC50196Simvastatin - d6CAS: 1002347-71-8纯度: >99.50%
An internal standard for the quantificaition of simvastatin
- GC60796D-Trimannuronic acidCAS: 66754-13-0纯度: >98.50%
D-Trimannuronicacid是一种从海藻中提取的藻酸盐低聚物，可以诱导小鼠巨噬细胞分泌TNF-α。D-Trimannuronicacid可用于疼痛和血管性痴呆的研究。
- GC62400LEESGGGLVQPGGSMK acetate纯度: >99.00%
LEESGGGLVQPGGSMK acetate，一种蛋白水解肽，是 Infliximab 的一种成分，可用于 Infliximab 的定量分析。Infliximab 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC43368 | D,L-1′-Acetoxychavicol Acetate | 52946-22-2 | >95.00% | |
A natural exportin 1 inhibitor | ||||
| GC43894 | IKK2 Inhibitor VI | 354811-10-2 | >95.00% | |
An inhibitor of IKK2 | ||||
| GC44097 | LY303511 (hydrochloride) | 854127-90-5 | >98.50% | |
An inhibitor of cell proliferation | ||||
| GC44388 | NF-κB Control | 201608-17-5 | >95.00% | |
A negative control peptide used with NF-κB inhibitor | ||||
| GC44943 | sPLA2 Inhibitor | 393569-31-8 | >95.00% | |
An orally active inhibitor of sPLA 2 -IIA | ||||
| GC45772 | 6(5H)-Phenanthridinone | 1015-89-0 | >98.00% | |
An inhibitor of PARP1 and 2 | ||||
| GC45798 | Rhein-13C4 | 1189928-10-6 | >95.00% | |
An internal standard for the quantification of rhein | ||||
| GC45960 | 9c(i472) | 2349374-37-2 | >95.00% | |
A 15-LO-1 inhibitor | ||||
| GC46015 | KY 05009 | 1228280-29-2 | >99.50% | |
A TNIK inhibitor | ||||
| GC46862 | Apigenin-d5 | 263711-74-6 | >99.00% | |
An internal standard for the quantification of apigenin | ||||
| GC47544 | Lauric Acid-13C | 93639-08-8 | >95.00% | |
An internal standard for the quantification of lauric acid | ||||
| GC48098 | SR 12343 | 2055101-86-3 | >98.00% | |
An IKKβ NBD mimetic | ||||
| GC48099 | SR 12460 | 2055101-66-9 | >98.00% | |
An IKKβ NBD mimetic | ||||
| GC48195 | trans-trismethoxy Resveratrol-d4 | 1089051-64-8 | >99.00% | |
An internal standard for the quantification of trans-trismethoxy resveratrol | ||||
| GC48202 | Treprostinil (diethanolamine salt) | 830354-48-8 | >98.00% | |
An agonist of IP 2 , DP 2 , and EP 2 receptors | ||||
| GC48292 | α-MSH (human, mouse, rat, porcine, bovine, ovine) (trifluoroacetate salt) | 171869-93-5 | >98.00% | |
A peptide hormone | ||||
| GC48827 | Flufenamic Acid-d4 | 1185071-99-1 | >99.00% | |
An internal standard for the quantification of flufenamic acid | ||||
| GC48907 | Metaxalone-d6 | 1189944-95-3 | >99.00% | |
An internal standard for the quantification of metaxalone | ||||
| GC50196 | Simvastatin - d6 | 1002347-71-8 | >99.50% | |
An internal standard for the quantificaition of simvastatin | ||||
| GC60225 | Licarin A | 51020-86-1 | >98.00% | |
LicarinA((+)-LicarinA)，可从多种植物中分离得到，显着降低二硝基苯肼-人血清白蛋白(DNP-HSA)刺激的RBL-2H3细胞。具有抗过敏作用。LicarinA降低TNF-α和PGD2产生，和COX-2表达。 | ||||
| GC60796 | D-Trimannuronic acid | 66754-13-0 | >98.50% | |
D-Trimannuronicacid是一种从海藻中提取的藻酸盐低聚物，可以诱导小鼠巨噬细胞分泌TNF-α。D-Trimannuronicacid可用于疼痛和血管性痴呆的研究。 | ||||
| GC61533 | UTL-5g | 646530-37-2 | >98.50% | |
UTL-5g (GBL-5g) is a novel small-molecule TNF-α inhibitor which can lower hepatotoxicity, nephrotoxicity and myelotoxicity induced by Cisplatin.DMSO is not recommended to dissolve platinum-based drugs, which can easily lead to drug inactivation. | ||||
| GC62346 | UCB-9260 | 1515888-53-5 | >98.00% | |
UCB-9260 is an orally active inhibitor that inhibits TNF signalling by stabilising an asymmetric form of the trimer. UCB-9260 binds TNF with Kd of 13 ?nM. UCB-9260 also inhibits NF-κB with IC50 of 202?nM after TNF stimulation. | ||||
| GC62400 | LEESGGGLVQPGGSMK acetate | - | >99.00% | |
LEESGGGLVQPGGSMK acetate，一种蛋白水解肽，是 Infliximab 的一种成分，可用于 Infliximab 的定量分析。Infliximab 是一种与 TNF-α 特异性结合的嵌合单克隆 IgG1 抗体。 | ||||