GlpBio

TNF-α

TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

TNF-α 相关产品(145)

  • GC74507 structure
    GC74507Asunercept
    CAS: 1450882-18-4
    纯度: >98.00%

    Asunercept (APG101;CAN008)是一种靶向CD95L的可溶性CD95-Fc融合蛋白。

  • GC74515 structure
    GC74515Benufutamab
    CAS: 2109730-69-8
    纯度: >98.00%

    Benufutamab（GEN1029）是一种死亡受体5（DR5）特异性激动抗体。

  • GC74542 structure
    GC74542Cinrebafusp alfa
    CAS: 2218515-90-1
    纯度: >98.00%

    Cinrebafusp alfa（PRS 343）是一种高亲和力CD137/HER2双特异性抗毒蛋白药物。

  • GC74560 structure
    GC74560Inezetamab
    CAS: 2568264-76-4
    纯度: >99.00%

    Inezetamab是一种双特异性抗CD40和抗MSLN IgG1单克隆抗体。

  • GC74563 structure
    GC74563Iratumumab
    CAS: 640735-09-7
    纯度: >98.00%

    Iratumumab (MDX-060)人抗cd30 IgG1κ单克隆抗体。

  • GC74580 structure
    GC74580Mitazalimab
    CAS: 2055640-86-1
    纯度: >98.00%

    Mitazalimab（ADC-1013；JNJ-64457107）是FcγR依赖性CD40激动剂，具有肿瘤导向活性。

  • GC74597 structure
    GC74597Ravagalimab
    CAS: 2050816-56-1
    纯度: >99.00%

    Ravagalimab（ABBV-323）是CD40拮抗剂（EC50:3.7nM）。

  • GC74604 structure
    GC74604Linvoseltamab
    CAS: 2408319-25-3
    纯度: >99.00%

    Linvoseltamab是一种针对BCMA （TNFRSF17）和CD3 epsilon的双特异性抗体。

  • GC74608 structure
    GC74608Elranatamab
    CAS: 2408850-14-4
    纯度: >97.00%

    Elranatamab (PF-06863135)是一种抗cd3e /TNFRSF17人IgG2κ单克隆抗体。

  • GN10030 structure
    GN10030Fisetin
    CAS: 528-48-3
    纯度: >98.50% / >98.00%

    Fisetin是一种天然黄酮醇，存在于许多水果和蔬菜中，具有多种生物活性。

  • GN10055 structure
    GN10055Mulberroside A
    CAS: 102841-42-9
    纯度: >98.00%

    A phenol with diverse biological activities

  • GN10151 structure
    GN10151Geraniin
    CAS: 60976-49-0
    纯度: >98.00%

    Geraniin是一种TNF-α释放抑制剂，IC 50 值为43µM，具有多种活性，包括抗癌、抗炎和抗高血糖活性。

  • GN10216 structure
    GN10216Shikonin
    CAS: 517-89-5
    纯度: >98.00%

    Shikonin是一种含醌的天然产物。Shikonin是一种有效的TMEM16A氯离子通道抑制剂，IC 50 为6.5μM。

  • GN10217 structure
    GN10217Hypaconitine
    CAS: 6900-87-4
    纯度: >98.00%

    A diterpene alkaloid with diverse biological activities

  • GN10254 structure
    GN10254Ginsenoside Rc
    CAS: 11021-14-0
    纯度: >98.00% / >99.50%

    A saponin with diverse biological activities

  • GN10280 structure
    GN10280Sinensetin
    CAS: 2306-27-6
    纯度: >99.50% / >98.00%

    An anti-inflammatory flavone

  • GN10335 structure
    GN10335Mesaconitine
    CAS: 2752-64-9
    纯度: >98.50%

    新乌头碱是乌头属植物的主要活性成分。

  • GN10415 structure
    GN10415Astilbin
    CAS: 29838-67-3
    纯度: >97.00%

    A flavonoid with diverse biological activities

  • GN10429 structure
    GN10429Neochlorogenic acid
    CAS: 906-33-2
    纯度: >98.00%

    A phenolic compound with diverse biological activities

  • GN10538 structure
    GN10538Ginsenoside Rh1
    CAS: 63223-86-9
    纯度: >98.00%

    A steroid glycoside with diverse biological activities

  • GN10727 structure
    GN10727Forsythoside B
    CAS: 81525-13-5
    纯度: >98.00%

    Forsythoside B是从传统中药植物连翘的叶子中分离的一种苯乙醇苷，具有多种生物活性，能够用于治疗炎症性疾病和促进血液循环。

  • GC15083 structure
    GC15083Celastrol
    CAS: 34157-83-0
    纯度: >99.50%

    Celastrol是一种蛋白酶体抑制剂，有效且优先的抑制纯化的20S蛋白酶体，IC 50 为2.5 μM。

  • GC14015 structure
    GC14015Lenalidomide hydrochloride
    CAS: 1243329-97-6

    An analog of thalidomide

  • GC11167 structure
    GC11167Necrostatin 2
    CAS: 852391-19-6
    纯度: >99.50%

    A potent inhibitor of necroptosis