GlpBio

TNF-α

TNF-α(肿瘤坏死因子-α)

Tumor necrosis factor alpha (TNF-α), belongs to the superfamily of TNF/TNFR cytokine superfamily, is a type II transmembrane protein (mTNF) with an intracellular N terminus that is produced as 26 kDa membrane-bound cytokine comprised of 233 amino acids. TNF-α also exists as a soluble cytokine (sTNF), which is a non-covalently bound 17 kDa trimer (157 amino acids with a 76 amino acid presequence) resulted from the cleavage of mTNF by TNF-α converting enzyme (TACE). Two distinct and highly affinitive receptors of TNF-α have been identified, including TNFR55 (a 55 kDa receptor) and TNFR75 (a 75 kDa receptor), through which multiple activities of TNF-α are mediated. TNF-α has been found to be involved in maintenance and homeostasis of the immune system, inflammation and host defence as well as a variety of pathological processes.

TNF-α 相关产品(145)

  • GC33825 structure
    GC33825Taurochenodeoxycholic acid (12-Deoxycholyltaurine)
    CAS: 516-35-8
    纯度: >98.00% / >99.00%

    Taurochenodeoxycholic acid (12-Deoxycholyltaurine)是一种牛磺酸结合胆汁酸。

  • GC33826 structure
    GC33826C 87
    CAS: 332420-90-3
    纯度: >98.00%

    C87是一种新型小分子TNFα抑制剂;高效抑制TNFα诱导的细胞毒性，IC50值为8.73μM。

  • GC33934 structure
    GC33934DCVC
    CAS: 13419-46-0
    纯度: >99.50%

    DCVC (S-[(1E)-1,2-dichloroethenyl]--L-cysteine) 是三氯乙烯 (TCE) 的生物活性代谢物。

  • GC34214 structure
    GC34214Adalimumab (Anti-Human TNF-alpha, Human Antibody)
    CAS: 331731-18-1
    纯度: >99.50%

    阿达木单抗（抗人 TNF-α，人抗体）是治疗类风湿性关节炎的主要疗法之一。

  • GC34513 structure
    GC34513C25-140
    CAS: 1358099-18-9
    纯度: >98.00%

    C25-140是一种能够抑制TRAF6-Ubc13相互作用的小分子化合物，能够直接与E3连接酶TNF受体相关因子6（TRAF6）结合，从而阻断TRAF6与Ubc13的相互作用，并因此降低TRAF6的活性。

  • GC34579 structure
    GC34579Etanercept
    CAS: 185243-69-0
    纯度: >95.00% / >98.00%

    Etanercept是一种竞争性肿瘤坏死因子（TNF）抑制剂，抑制TNF-α和TNF-β与细胞表面受体的结合。

  • GC35184 structure
    GC351847,3',4'-Tri-O-methylluteolin
    CAS: 29080-58-8
    纯度: >99.00%

    7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone) 是一种来自草药马鞭草科 (Lippia nodiflora L.) 的类黄酮，Lippia nodiflora L. 已被证明具有抗炎，解热，镇咳，抗糖尿病，抗癌和抗黑素生成特性。7,3',4'-Tri-O-methylluteolin 以浓度依赖方式明显抑制促炎细胞因子，如 TNF-α，IL-6 和 IL-1β。7,3',4'-Tri-O-methylluteolin 显著降低在转录水平的诱导型一氧化氮合酶和环加氧酶-2 的 mRNA 表达。

  • GC35377 structure
    GC35377Apratastat
    CAS: 287405-51-0
    纯度: >99.00%

    Apratastat是一种口服活性、可逆的双重抑制剂，能够抑制肿瘤坏死因子-α转换酶（TACE；IC 50 =81.7ng/mL）和基质金属蛋白酶（MMPs）的活性。

  • GC35440 structure
    GC35440AX-024
    CAS: 1370544-73-2
    纯度: >98.00%

    An inhibitor of the CD3ε-Nck interaction

  • GC35523 structure
    GC35523Bioymifi
    CAS: 1420071-30-2
    纯度: >98.00%

    A DR5 agonist

  • GC36106 structure
    GC36106Gamma-glutamylcysteine (TFA)
    CAS: 283159-88-6

    Gamma-glutamylcysteine (TFA) ((γ-glutamylcysteine (TFA))是谷胱甘肽 (GSH) 合成的中间体，一种作为抗氧化酶谷胱甘肽过氧化物酶 (GPx) 的必需辅助因子的二肽。 Gamma-glutamylcysteine (TFA) 上调抗炎细胞因子 IL-10 的水平，降低促炎细胞因子 (TNF-α，IL-6 和 IL-1β) 的水平，并减弱在寡聚 Aβ40 处理的星形胶质细胞中金属蛋白酶活性的变化。

  • GC37555 structure
    GC37555Roquinimex
    CAS: 84088-42-6
    纯度: >98.50%

    An immunomodulator with diverse biological activities

  • GC38868 structure
    GC38868TRAF-STOP inhibitor 6877002
    CAS: 433249-94-6
    纯度: >99.50% / >98.00%

    TRAF-STOP inhibitor 6877002是一种抑制CD40-TRAF6相互作用的选择性抑制剂（TRAF-STOPs）。

  • GC39070 structure
    GC39070Negletein
    CAS: 29550-13-8

    Negletein 是一种神经保护剂，可增强神经生长因子的作用并诱导 PC12 细胞中的神经突向外生长。Negletein 通过抑制 TNF-α 和 IL-1β 表现出有希望的抗炎活性，其 IC50 值分别为 16.4 和 10.8 μM。

  • GC39815 structure
    GC39815Semapimod tetrahydrochloride
    CAS: 164301-51-3
    纯度: >98.00%

    Semapimod tetrahydrochloride (CNI-1493) 是促炎细胞因子产生 (proinflammatory cytokine) 的抑制剂，可抑制TNF-α、IL-1β 和 IL-6。Semapimod tetrahydrochloride 抑制巨噬细胞 p38 MAPK 和一氧化氮生成。Semapimod tetrahydrochloride 抑制 TLR4 信号 (IC50≈0.3 μM)。Semapimod tetrahydrochloride 在多种炎症和自身免疫性疾病中具有潜在的作用。

  • GC40650 structure
    GC40650CAY10706
    CAS: 1881270-27-4
    纯度: >95.00%

    A TrxR inhibitor

  • GC41342 structure
    GC41342Terrecyclic Acid
    CAS: 83058-94-0
    纯度: >95.00%

    A sesquiterpene

  • GC42880 structure
    GC42880Avenanthramide-C methyl ester
    CAS: 955382-52-2
    纯度: >90.00%

    Inhibitor of NF-κB activation

  • GC42925 structure
    GC42925Berteroin
    CAS: 4430-42-6
    纯度: >95.00%

    A natural sulforaphane analog

  • GC42953 structure
    GC42953BMS 345541 (trifluoroacetate salt)
    纯度: >98.00%

    BMS 345541 is a cell permeable inhibitor of the IκB kinases IKKα and IKKβ (IC50s = 4 and 0.3 μM).

  • GC43110 structure
    GC43110C8 Galactosylceramide (d18:1/8:0)
    CAS: 41613-16-5
    纯度: >98.00%

    A synthetic bioactive sphingolipid

  • GC43176 structure
    GC43176CAY10575
    CAS: 916985-21-2
    纯度: >95.00%

    An IKKβ and Plk1 inhibitor

  • GC43189 structure
    GC43189CAY10681
    CAS: 1542066-69-2
    纯度: >98.00%

    A dual modulator of p53-MDM2 interaction and NF-κB signaling

  • GC43190 structure
    GC43190CAY10682
    CAS: 1542066-74-9
    纯度: >98.00%

    A dual inhibitor of p53-Mdm2 interaction and NF-κB signaling