Maslinic acid is a pentacyclic triterpene acid widely found in olives and other plants. Maslinic acid has multiple biological activities such as anti-inflammatory, antioxidant, anti-tumor, hypoglycemic, and neuroprotective[1].
Maslinic Acid (1-10μM; 24h) was proved to induce cell autophagy by disrupting the combination of Bcl2 and Beclin1 in rat PC12 cells[2]. Maslinic acid (6.25, 12.5, 25, 50mM; 48h) significantly decreased lipid accumulation in oleic acid-incubated HepG2 cells[3]. Maslinic acid (0, 25, 30, 35, 40, 45μM; 48h) decreased total cell viability and induced DNA condensation, damage, and fragmentation in HeLa cells[4].
Maslinic Acid (5, 10, 20mg/kg; ip; 8 weeks) treatment for 8 weeks repressed the oxidative stress and inflammation in the kidney of diabetic mice[5]. Maslinic acid (0.3, 1, 3mg/kg; po; administered 3, 6, 9, 12h before kill) enhanced the ERK–CREB and PI3K–Akt signalling pathways in the hippocampus[6].
References:
[1]He Y, Wang Y, Yang K, et al. Maslinic acid: a new compound for the treatment of multiple organ diseases[J]. Molecules, 2022, 27(24): 8732.
[2]Germano A, Saba L, De Francia S, et al. CYP11B1 has no role in mitotane action and metabolism in adrenocortical carcinoma cells[J]. PloS one, 2018, 13(5): e0196931.
[3]Liou C J, Dai Y W, Wang C L, et al. Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway[J]. The FASEB Journal, 2019, 33(11): 11791.
[4]Lu K W, Yang M D, Peng S F, et al. Maslinic acid induces DNA damage and impairs DNA repair in human cervical cancer HeLa cells[J]. Anticancer Research, 2020, 40(12): 6869-6877.
[5]Gao H, Wu H. Maslinic acid activates renal AMPK/SIRT1 signaling pathway and protects against diabetic nephropathy in mice[J]. BMC Endocrine Disorders, 2022, 22(1): 25.
[6]Bae H J, Kim J, Kim J, et al. The effect of maslinic acid on cognitive dysfunction induced by cholinergic blockade in mice[J]. British Journal of Pharmacology, 2020, 177(14): 3197-3209.
Maslinic Acid是一种五环三萜酸，广泛存在于橄榄和其他植物中。Maslinic Acid具有抗炎、抗氧化、抗肿瘤、降血糖和神经保护等多种生物活性[1]。
Maslinic Acid（1-10μM；24h）可通过破坏大鼠PC12细胞中Bcl2和Beclin1的结合诱导细胞自噬[2]。Maslinic Acid（6.25、12.5、25、50mM；48h）可显著减少油酸诱导的HepG2细胞的脂质积累[3]。Maslinic Acid（0、25、30、35、40、45μM；48h）会降低HeLa细胞的总存活率，并诱导DNA凝聚、损伤和破碎[4]。
Maslinic Acid（5、10、20mg/kg；ip；8weeks）治疗 8 周可抑制糖尿病小鼠肾脏的氧化应激和炎症[5]。Maslinic Acid（0.3、1、3mg/kg；po；在处死前3、6、9和12h给药）增强了海马中 ERK-CREB 和 PI3K-Akt 信号通路[6]。