GlpBio

Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Autophagy 相关产品(1140)

  • GC35812 structure
    GC35812Dasatinib hydrochloride
    CAS: 854001-07-3
    纯度: >98.50% / >99.00%

    An inhibitor of Abl and Src

  • GC35820 structure
    GC35820DDD107498 succinate
    CAS: 2444781-71-7
    纯度: >98.50%

    DDD107498 (M-5717, DDD-498) is a P. falciparum translation elongation factor 2 inhibitor. DDD107498 exhibits a potent and novel spectrum of antimalarial activity against multiple life-cycle stages of the Plasmodium parasite.

  • GC35832 structure
    GC35832Dehydrocorydaline chloride
    CAS: 10605-03-5
    纯度: >98.00%

    An alkaloid with diverse biological activities

  • GC35969 structure
    GC35969eIF4A3-IN-1
    CAS: 2095486-67-0
    纯度: >99.50%

    eIF4A3-IN-1 (compound 53a) 是一种选择性的真核起始因子 4A3 (eIF4A3) 抑制剂 (IC50=0.26 μM; Kd=0.043 μM)，eIF4A3-IN-1 与 eIF4A3 的非 ATP 结合位点结合，并在 10 μM 和 3 μM 时明显抑制细胞无义介导的 RNA 衰变 (NMD), 可作为进一步研究 eIF4A3、外显子连接复合体 (EJC) 和 NMD 的探针。

  • GC35982 structure
    GC35982EN6
    CAS: 1808714-73-9
    纯度: >99.00%

    An activator of autophagy

  • GC35998 structure
    GC35998Episilvestrol
    CAS: 697235-39-5
    纯度: >99.50%

    Episilvestrol 是 silvestrol 的衍生物，从 Aglaia silvestris 中分到，能够抑制 eIF4A 靶作用的转录过程。

  • GC36003 structure
    GC36003Erlotinib mesylate
    CAS: 248594-19-6

    An EGFR tyrosine kinase inhibitor

  • GC36023 structure
    GC36023FAAH inhibitor 1
    CAS: 326866-17-5

    FAAH inhibitor 1是一种选择性的、可逆的脂肪酸酰胺水解酶（FAAH）抑制剂，IC 50 值为18±8nM。

  • GC36061 structure
    GC36061Fluvastatin D6 sodium

    An internal standard for the quantification of fluvastatin

  • GC36063 structure
    GC36063FMK 9a
    CAS: 1955550-51-2

    FMK 9a是autophagin-1的抑制剂，在FRET和LRA试验中测定的IC50值分别为80 和73 nM。

  • GC36130 structure
    GC36130Gemcitabine elaidate
    CAS: 210829-30-4
    纯度: >98.00%

    A prodrug form of gemcitabine

  • GC36136 structure
    GC36136Ginkgolide K
    CAS: 153355-70-5
    纯度: >99.50%

    A terpene trilactone with diverse biological activities

  • GC36149 structure
    GC36149GLPG2451
    CAS: 2055015-61-5
    纯度: >99.50%

    GLPG2451 是一种囊性纤维化跨膜电导调节器 (CFTR) 的增强剂，有效增强低温挽救的 F508del CFTR，EC50 为 11.1 nM。

  • GC36163 structure
    GC36163Glycycoumarin
    CAS: 94805-82-0
    纯度: >99.50%

    Glycycoumarin 是一种甘草中主要的生物活性香豆素。Glycycoumarin 通过激活自噬，抑制内质网应激介导的 JNK 和 GSK-3 介导的线粒体途径，来抑制肝细胞脂性凋亡。Glycycoumarin 能直接靶向 T-LAK 细胞源蛋白激酶发挥抗肝癌活性 。

  • GC36215 structure
    GC36215Heparin Lithium salt
    CAS: 9045-22-1
    纯度: 不显示

    Heparin Lithium salt 是一种抗凝剂，可与 抗凝血酶III (ATIII) 可逆地结合 (50-400 U/Kg)。

  • GC36329 structure
    GC36329Irinotecan hydrochloride
    CAS: 100286-90-6
    纯度: >99.00%

    A potent inhibitor of DNA topoisomerase I

  • GC36339 structure
    GC36339Isorhapontigenin
    CAS: 32507-66-7
    纯度: >99.50%

    Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.

  • GC36346 structure
    GC36346Isosorbide mononitrate
    CAS: 16051-77-7
    纯度: >99.50%

    A nitric oxide donor with cardioprotective activity

  • GC36356 structure
    GC36356Ixazomib citrate
    CAS: 1239908-20-3
    纯度: >99.50%

    Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.

  • GC36427 structure
    GC36427Lasalocid sodium
    CAS: 25999-20-6

    An ionophore antibiotic

  • GC36447 structure
    GC36447Licochalcone E
    CAS: 864232-34-8
    纯度: >99.50%

    Licochalcone E 是可从Glycyrrhiza inflate 中提取到的黄酮类化合物，通过抑制AKT 和 MAPK 的激活来抑制NF-κB 和 AP-1 的转录活性。

  • GC36479 structure
    GC36479Loperamide hydrochloride
    CAS: 34552-83-5
    纯度: >99.50%

    An Analytical Reference Standard

  • GC36517 structure
    GC36517LYN-1604 hydrochloride
    CAS: 2216753-86-3

    A ULK1 activator

  • GC36646 structure
    GC36646Momelotinib Mesylate
    CAS: 1056636-07-7

    Momelotinib Mesylate (CYT387 Mesylate) 是一种 ATP 竞争性的 JAK1/JAK2 抑制剂，IC50 值分别为 11 nM/18 nM，对其选择性约是 JAK3 的 10 倍。