Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Autophagy 相关产品(1140)

  • GC36671 structure
    GC36671N-Benzyllinolenamide
    CAS: 883715-18-2

    N-?Benzyllinolenamide 是从玛卡中得到的玛卡酰胺,为脂肪酰胺水解酶 (FAAH) 抑制剂,IC50 值为 41.8 μM。

  • GC36690 structure
    GC36690Nampt-IN-3
    CAS: 2121591-52-2
    纯度: >99.00%

    Nampt-IN-3 (Compound 35) 同时抑制烟酰胺磷酸核糖转移酶 (NAMPT) 和 HDAC,IC50 分别为 31 nM 和 55 nM。Nampt-IN-3 有效诱导细胞凋亡 (apoptosis) 和自噬 (autophagy),最终导致细胞死亡。

  • GC36703 structure
    GC36703N-Benzyloleamide
    CAS: 883715-21-7
    纯度: >98.00%

    N-Benzyloleamide 是从 Lepidium meyenii (Maca) 中分离出的一种 maccamide。N-Benzyloleamide 不可逆地抑制脂肪酸酰胺水解酶 (FAAH)。N-Benzyloleamide 影响能量代谢,显示抗氧化和抗疲劳活性。

  • GC36736 structure
    GC36736Nicodicosapent
    CAS: 1269181-69-2
    纯度: >98.00%

    Nicodicosapent 是一种脂肪酸烟酸共轭体,可以抑制固醇调节元件结合蛋白 (SREBP) 的活性,调节胆固醇代谢的蛋白质如 PCSK9,HMG-CoA reductase,ATP citrate lyase 和 NPC1L1 等的活性。

  • GC36758 structure
    GC36758Norepinephrine hydrochloride
    CAS: 329-56-6
    纯度: >99.50% / >98.00%

    Norepinephrine hydrochloride是一种作用于α1、α2、β1等肾上腺素能受体,具有收缩血管、调节血压等药理作用的儿茶酚胺类神经递质。

  • GC36806 structure
    GC36806Omeprazole D3
    CAS: 922731-01-9
    纯度: >98.50%

    An internal standard for the quantification of omeprazole

  • GC36821 structure
    GC36821OSU-T315
    CAS: 2070015-22-2
    纯度: >98.00%

    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).

  • GC36847 structure
    GC36847Pantoprazole sodium
    CAS: 138786-67-1
    纯度: >99.50%

    A proton pump inhibitor

  • GC36848 structure
    GC36848Pantoprazole sodium hydrate
    CAS: 164579-32-2
    纯度: >98.00%

    A proton pump inhibitor

  • GC36855 structure
    GC36855Paris saponin VII
    CAS: 68124-04-9
    纯度: >98.00% / >98.50%

    Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

  • GC36868 structure
    GC36868Pennogenin 3-O-beta-chacotrioside
    CAS: 55916-52-4
    纯度: >99.50%

    Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.

  • GC36879 structure
    GC36879PF-04457845
    CAS: 1020315-31-4
    纯度: >99.00%

    A selective FAAH inhibitor

  • GC36928 structure
    GC36928Pirarubicin Hydrochloride
    CAS: 95343-20-7
    纯度: >98.50%

    An anthracycline antitumor antibiotic

  • GC36930 structure
    GC36930Pitavastatin D4
    CAS: 2070009-71-9

    Pitavastatin D4是Pitavastatin氘代化合物标准品。

  • GC36963 structure
    GC36963Pregnenolone monosulfate
    CAS: 1247-64-9
    纯度: >98.00%

    Pregnenolone monosulfate是包括甾体酮在内的各种甾体激素的主要前体,具有多种生物学功能。

  • GC37559 structure
    GC37559Rosuvastatin D3 Sodium
    CAS: 1279031-70-7

    Rosuvastatin D3钠盐是Rosuvastatin氘代化合物标准品。

  • GC37560 structure
    GC37560Rosuvastatin D6 Calcium

    Rosuvastatin D6钙盐是Rosuvastatin的氘代化合物标准品。

  • GC37561 structure
    GC37561Rosuvastatin D6 Sodium

    An internal standard for the quantification of rosuvastatin

  • GC37575 structure
    GC37575Ruxolitinib sulfate
    CAS: 1092939-16-6

    A potent, selective JAK1/JAK2 inhibitor

  • GC37595 structure
    GC37595SB 242235
    CAS: 193746-75-7
    纯度: >98.50%

    A p38α MAPK inhibitor

  • GC37601 structure
    GC37601SBE13
    CAS: 775294-82-1

    A potent Plk1 inhibitor

  • GC37630 structure
    GC37630Sevelamer
    CAS: 52757-95-6

    Sevelamer HCl is a phosphate binding drug used to treat hyperphosphatemia via binding to dietary phosphate and prevents its absorption.

  • GC37646 structure
    GC37646SKF-86002
    CAS: 72873-74-6
    纯度: >99.00%

    An anti-inflammatory agent

  • GC37664 structure
    GC37664Sorafenib (D3)
    CAS: 1130115-44-4
    纯度: >99.00%

    An internal standard for the quantification of sorafenib