GlpBio

Ixazomib citrate

目录号: GC36356纯度: >99.50%同义词: 枸橼酸艾沙佐米; MLN9708
Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
Ixazomib citrate
Cas No.: 1239908-20-3
规格价格库存数量操作
5mg¥350.00现货
1
10mg¥490.00现货
1
50mg¥1,050.00现货
1
100mg¥1,750.00现货
1
200mg¥0.01现货
1
500mg¥0.01现货
1
10mM (in 1mL DMSO)¥399.00现货
1
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文献被引

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产品描述 Description

Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.

[1] Erik Kupperman, et al. Cancer Res. 2010 Mar 1;70(5):1970-80. [2] Edmund C Lee, et al. Clin Cancer Res . 2011 Dec 1;17(23):7313-23. [3] Gregory T.Notte. Annual Reports in Medicinal Chemistry. Volume 48, 2013, Pages 451-469.

产品文档 Product Documents

Purity:>99.50%

化学性质Chemical Properties

CAS 号
1239908-20-3
同义词
枸橼酸艾沙佐米; MLN9708
SMILES
O=C(O)CC1(CC(O)=O)OB([C@@H](NC(CNC(C2=CC(Cl)=CC=C2Cl)=O)=O)CC(C)C)OC1=O
分子式
C20H23BCl2N2O9
分子量
517.12 g/mol
溶解性
DMSO: ≥ 100 mg/mL (193.38 mM)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol