GlpBio

TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

研究方向

TGF-β / Smad Signaling 相关产品(360)

  • GC19034 structure
    GC19034AR-13324 mesylate
    CAS: 1422144-42-0

    AR-13324 是一种有效的 ROCK I 和 ROCK II 抑制剂，已被证明可在低浓度下诱导培养的人和猪 TM 细胞发生形态学变化。

  • GC19177 structure
    GC19177GSK180736A
    CAS: 817194-38-0
    纯度: >98.00% / >99.50%

    A ROCK1 and GRK2 inhibitor

  • GC19234 structure
    GC19234LY3200882
    CAS: 1898283-02-7
    纯度: >99.50%

    An inhibitor of TGF-βRI

  • GC19338 structure
    GC19338SRI-011381 hydrochloride
    CAS: 2070014-88-7
    纯度: >98.00% / >99.00%

    SRI-011381 hydrochloride是一种具口服活性的转化生长因子β（TGF-β）信号通路的激活剂，具有神经保护作用。

  • GC19447 structure
    GC19447SM 16
    CAS: 614749-78-9
    纯度: >99.50%

    An inhibitor of ALK5

  • GC25482 structure
    GC25482GSK269962A HCl
    CAS: 2095432-71-4

    GSK269962A HCl (GSK269962B, GSK269962) is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.

  • GC25662 structure
    GC25662N-Desmethyltamoxifen
    CAS: 31750-48-8

    N-Desmethyltamoxifen, the major metabolite of Tamoxifen in humans and a ten-fold more potent protein kinase C (PKC) inhibitor than Tamoxifen, also is a potent regulator of ceramide metabolism in human AML cells, limiting ceramide glycosylation, hydrolysis, and sphingosine phosphorylation.

  • GC25669 structure
    GC25669Nilotinib hydrochloride
    CAS: 923288-95-3

    Nilotinib hydrochloride (AMN-107) is the hydrochloride salt form of nilotinib, an orally bioavailable Bcr-Abl tyrosine kinase inhibitor with antineoplastic activity.

  • GC26000 structure
    GC26000TP0427736 HCl
    CAS: 864374-00-5

    TP0427736 is a potent inhibitor of ALK5 kinase activity with an IC50 of 2.72 nM and this effect is 300-fold higher than the inhibitory effect on ALK3 (IC50 = 836 nM for ALK3). It also inhibits Smad2/3 phosphorylation in A549 cells induced by TGF-β1 with an IC50 value of 8.68 nM.

  • GC26055 structure
    GC26055WAY-301398
    CAS: 312607-68-4

    WAY-301398 (6-methoxynaphthalene) can bind to protein kinase C (PKC).

  • GC26065 structure
    GC26065WAY-354831
    CAS: 330572-32-2

    WAY-354831 exhibits antibacterial activity.

  • GC30200 structure
    GC30200PKC-theta inhibitor
    CAS: 736048-65-0
    纯度: >99.50%

    PKC-theta inhibitor (compound 20) inhibits PKC-θ with an IC50 of 18 nM.

  • GC30545 structure
    GC30545Malantide
    CAS: 86555-35-3
    纯度: >98.50%

    Malantide是一种十二肽，能够被PKA磷酸化，并且能够增强PKA的活性。

  • GC31650 structure
    GC31650Halofuginone (RU-19110)
    CAS: 55837-20-2
    纯度: >98.00%

    Halofuginone (RU-19110)是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，K i 值为18.3nM。

  • GC31656 structure
    GC31656Ingenol Mebutate (Ingenol 3-angelate)
    CAS: 75567-37-2
    纯度: >99.00%

    A natural cytotoxic diterpene ester

  • GC31711 structure
    GC31711PKC-IN-1
    CAS: 1046787-18-1
    纯度: >98.00% / >98.50%

    PKC-IN-1是一种有效的，ATP-竞争性的，可逆的PKC抑制剂，对人PKCβ和PKCα的Ki值分别为5.3和10.4nM，对人PKCα，PKCβI，PKCβII，PKCθ，PKCγ，PKCmu和PKCε的IC50值分别为2.3，8.1，7.6，25.6，57.5，314，808nM。

  • GC31883 structure
    GC31883ROCK2-IN-2
    CAS: 1995065-79-6

    ROCK2-IN-2是一种选择性ROCK2抑制剂，IC50<1μM。详细信息请参考专利文献US20180093978A1中的化合物A-30。

  • GC31892 structure
    GC31892Decursin ((+)-Decursin)
    CAS: 5928-25-6
    纯度: >98.00%

    A phytochemical with diverse biological activities

  • GC31912 structure
    GC31912VTX-27
    CAS: 1321924-70-2
    纯度: >99.50%

    A PKCθ inhibitor

  • GC31950 structure
    GC31950Halofuginone hydrobromide (RU-19110 (hydrobromide))
    CAS: 64924-67-0
    纯度: >99.50%

    Halofuginone hydrobromide (RU-19110 (hydrobromide))是febrifugine的衍生物，可抑制prolyl tRNA synthetase活性，K i 值为18.3nM。

  • GC31952 structure
    GC31952ROCK-IN-1
    CAS: 934387-35-6

    ROCK-IN-1是一种有效的ROCK抑制剂，能够抑制ROCK2的活性，IC50值为1.2nM。

  • GC31959 structure
    GC31959AS2521780
    CAS: 1214726-89-2

    AS2521780是新颖的PKCθ选择性抑制剂，IC50值为0.48nM。

  • GC32250 structure
    GC32250Chebulinic acid
    CAS: 18942-26-2
    纯度: >98.00%

    An ellagitannin with diverse biological activities

  • GC32703 structure
    GC32703Asciminib (ABL001)
    CAS: 1492952-76-7
    纯度: >99.50%

    An allosteric inhibitor of Abl1