GlpBio

TGF-β / Smad Signaling

TGF-β / Smad Signaling(TGF-β / Smad 信号转导)

Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).

TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.

研究方向

TGF-β / Smad Signaling 相关产品(360)

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    GC32714Mitoxantrone (mitozantrone)
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    纯度: >98.00%

    米托蒽醌Mitoxantrone是一种抗肿瘤的蒽醌衍生物。

  • GC32728 structure
    GC32728LSKL, Inhibitor of Thrombospondin TSP-1
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    纯度: >98.00% / >99.50%

    LSKL, Inhibitor of Thrombospondin TSP-1是一种来源于潜伏相关蛋白（LAP）-TGFβ的四肽，可竞争性结合抑制TGF-β1。

  • GC32788 structure
    GC32788SJ000291942
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    纯度: >98.00%

    A BMP signaling activator

  • GC32811 structure
    GC32811LXS196
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    纯度: >99.50%

    A PKC inhibitor

  • GC32840 structure
    GC32840R-268712
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    纯度: >99.50%

    R-268712 is a potent and selective inhibitor of ALK5 with an IC50 of 2.5 nM.

  • GC32867 structure
    GC32867Flumatinib (HHGV678)
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    纯度: >98.00%

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  • GC32868 structure
    GC32868BDP5290
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    纯度: >98.50%

    BDP5290对MRCKβ、ROCK1、ROCK2的IC50值分别为17nM、230nM、123nM和100nM，是ROCK和MRCK的有效抑制剂。

  • GC32870 structure
    GC32870Ingenol ((-)-Ingenol)
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    纯度: >98.00%

    A PKC activator

  • GC32914 structure
    GC32914EMT inhibitor-1
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    纯度: >99.00%

    EMTinhibitor-1是Hippo，TGF-β和Wnt信号通路的抑制剂，并拥有抗肿瘤活性。

  • GC33120 structure
    GC33120ZINC00881524
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    纯度: >99.00%

    A ROCK inhibitor

  • GC33201 structure
    GC33201GZD856
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    GZD856是一种新型，有口服活性的PDGFRα/β抑制剂，IC50分别为68.6和136.6nM。具有抗肺癌活性。也是Bcr-AblT315I的抑制剂，对Bcr-Abl和T315I突变型的IC50分别为19.9和15.4 nM。

  • GC33310 structure
    GC33310Rho-Kinase-IN-1
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    纯度: >99.50%

    Rho-Kinase-IN-1是一个rho激酶抑制剂，来自专利US20090325960A1，化合物1.008。

  • GC33343 structure
    GC33343BCR-ABL-IN-1
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  • GC33351 structure
    GC33351CZC-8004 (CZC-00008004)
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    纯度: >99.50%

    A tyrosine kinase inhibitor

  • GC33368 structure
    GC33368BCR-ABL-IN-2
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  • GC33901 structure
    GC33901Pentanoic acid
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    纯度: >99.00%

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  • GC34060 structure
    GC34060Disitertide (P144)
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    纯度: >98.00%

    Disitertide (P144)是转化生长因子β1（TGF-β1）受体I型的特异性抑制剂。

  • GC34300 structure
    GC34300AR-13324 analog mesylate
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    AR-13324类似物甲磺酸盐是AR-13324的类似物。

  • GC34493 structure
    GC34493BIBF0775
    CAS: 334951-90-5
    纯度: >99.50%

    BIBF-0775 is a selective inhibitor of transforming growth factor β Receptor I (TGFβRI,Alk5) with an IC50 of 34nM.

  • GC35210 structure
    GC35210A 83-01 sodium salt
    CAS: 2828431-89-4
    纯度: >98.00%

    A TGF-β type I receptor inhibitor

  • GC35442 structure
    GC35442Azaindole 1
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    纯度: >98.00%

    A ROCK1 and ROCK2 inhibitor

  • GC35462 structure
    GC35462Bafetinib
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    纯度: >99.50%

    A Bcr-Abl inhibitor

  • GC35530 structure
    GC35530BJE6-106
    CAS: 1564249-38-2

    BJE6-106 (B106) 是一种有效的选择性 PKCδ 抑制剂，IC50 值为 0.05 μM，BJE6-106 (B106) 靶向 PKCδ 的选择性是 PKC 同工酶 PKCα 的 1000倍 (IC50=50 μM)。BJE6-106 (B106) 可以诱导 caspase 依耐性细胞凋亡 (apoptosis)。BJE6-106 (B106) 具有肿瘤特异性作用。

  • GC35651 structure
    GC35651Cenisertib
    CAS: 871357-89-0
    纯度: >99.50%

    Cenisertib (AS-703569) 是一种多激酶抑制剂，可抑制 Aurora-kinase-A/B，ABL1，AKT，STAT5, FLT3 的活性。 Cenisertib 通过抑制肿瘤肥大细胞 (MC) 中几种不同分子靶标的活性抑制其生长。 Cenisertib 抑制异种移植模型中胰腺癌，乳腺癌，结肠癌，卵巢癌和肺癌以及白血病的肿瘤生长。