SJ000291942 is a bone morphogenic protein (BMP) signaling activator.1 It activates BMP4 in C33A-2D2 human cervical carcinoma clonal reporter cells (EC50 = ≤1 ?M). SJ000291942 (0.1-50 ?M) induces ventralization, as well as increases expression of the BMP target genes bmp2b and szl and the cooperatively-induced BMP target genes vent and vox in zebrafish embryos. It also induces BMP-dependent osteoblastic differentiation of C2C12 murine myoblasts.
1.Genthe, J.R., Min, J., Farmer, D.M., et al.Ventromorphins: A new class of small molecule activators of the canonical BMP signaling pathwayACS Chem. Biol.12(9)2436-2447(2017)