GlpBio

Wnt/β-catenin

Wnt/β-catenin(Wnt/β-连环蛋白)

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Wnt/β-catenin 相关产品(139)

  • GC10950 structure
    GC10950IWR-1-endo
    CAS: 1127442-82-3
    纯度: >99.00% / >98.00%

    IWR-1-endo 是一种有效的 Wnt 反应抑制剂，可阻断基于细胞的 Wnt/β-catenin 通路报告基因反应，IC 50 值为 180 nM。

  • GC11548 structure
    GC11548Tankyrase Inhibitors (TNKS) 49

    Tankyrase inhibitor

  • GC12134 structure
    GC12134FH535
    CAS: 108409-83-2
    纯度: >99.50%

    An inhibitor of β-catenin signaling

  • GC12781 structure
    GC12781XAV-939
    CAS: 284028-89-3
    纯度: >98.50% / >98.00%

    XAV-939 选择性抑制 β-连环蛋白介导的转录。

  • GC12869 structure
    GC12869JW 55
    CAS: 664993-53-7
    纯度: >99.50%

    A TNKS1/2 inhibitor

  • GC13658 structure
    GC13658Wnt-C59
    CAS: 1243243-89-1
    纯度: >99.50%

    Wnt-C59是Mboat（膜结合的O-酰脱糖酶）家族成员Porcupine（Porcn）的高度有效抑制剂，IC 50 值为74pM，能够抑制Wnt信号传导。

  • GC14572 structure
    GC14572KY 02111
    CAS: 1118807-13-8
    纯度: >99.50%

    Induces stem cell differentiation

  • GC14882 structure
    GC14882Salinomycin
    CAS: 53003-10-4
    纯度: >98.00%

    A selective cancer stem cell inhibitor

  • GC15041 structure
    GC15041Tankyrase Inhibitors (TNKS) 22

    Tankyrase inhibitor

  • GC16454 structure
    GC16454IWP-2
    CAS: 686770-61-6
    纯度: >99.00% / >99.50% / >98.00%

    IWP-2 是Wnt信号通路中Porcupine 酶的特异性抑制剂,IC50值为 27 nM。

  • GC16702 structure
    GC16702CHIR-99021 (CT99021)
    CAS: 252917-06-9
    纯度: >99.00% / >98.00%

    CHIR-99021是最常用的GSK-3β抑制剂，被认为是标准的小分子Wnt激动剂。

  • GC16893 structure
    GC16893ICG 001
    CAS: 780757-88-2
    纯度: >99.50% / >98.00%

    ICG001 是一种靶向 Wnt/β-catenin 通路的小分子抑制剂。

  • GC17153 structure
    GC17153CHIR-99021 (CT99021) HCl
    CAS: 1797989-42-4
    纯度: >99.50%

    A selective GSK3 inhibitor

  • GC17708 structure
    GC17708IWP-L6
    CAS: 1427782-89-5
    纯度: >99.50%

    A potent inhibitor of Porcupine

  • GC18107 structure
    GC18107Salinomycin sodium salt
    CAS: 55721-31-8
    纯度: >98.00%

    Salinomycin sodium salt是一种由 Streptomyces albus 发酵产生的大环聚醚离子载体抗生素。

  • GC10138 structure
    GC10138JW 67
    CAS: 442644-28-2

    JW 67 抑制经典 Wnt 信号传导，IC50 为 1.17μM。 JW 67 影响由 β-catenin/GSK-3β/AXIN/APC/CK1 组成的多蛋白复合物，该复合物迅速降低活性 β-catenin，随后下调 Wn\u200b\u200bt 靶基因。 JW 67 还抑制结直肠癌细胞的生长。

  • GC10253 structure
    GC10253CCT 031374 hydrobromide
    CAS: 1219184-91-4

    An inhibitor of β-catenin/TCF complex signaling

  • GC10472 structure
    GC10472ISX 9
    CAS: 832115-62-5
    纯度: >98.50%

    ISX 9 是成体神经干细胞分化的有效诱导剂。

  • GC10854 structure
    GC10854IDE 2
    CAS: 1136466-93-7
    纯度: >98.00%

    An inducer of definitive endoderm from embryonic stem cells

  • GC10910 structure
    GC10910IQ 1
    CAS: 331001-62-8
    纯度: >99.50%

    A stem cell pluripotency factor

  • GC11115 structure
    GC11115Pamidronate
    CAS: 40391-99-9
    纯度: >98.00%

    An FPP synthase inhibitor that inhibits bone resorption

  • GC11454 structure
    GC11454Neurodazine
    CAS: 937807-66-4
    纯度: >98.00%

    Neurodazine作为一种神经源性诱导剂，能够促进多能干细胞的神经发生。

  • GC11674 structure
    GC11674WIKI4
    CAS: 838818-26-1
    纯度: >99.50%

    A potent TNKS1/2 inhibitor

  • GC11775 structure
    GC11775Nefopam HCl
    CAS: 23327-57-3
    纯度: >99.50%

    Nefopam HCl (Fenazoxine hydrochloride) 是一种中枢作用但非阿片类镇痛药，用于缓解中度至重度疼痛。