Wnt/β-catenin
Wnt/β-catenin(Wnt/β-连环蛋白)
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Wnt/β-catenin 相关产品(139)
- GC453544β-Hydroxywithanolide ECAS: 54334-04-2纯度: >95.00%
A withanolide with anti-inflammatory and anticancer activities
- GC50323AMBMP hydrochlorideCAS: 2095432-75-8
AMBMP hydrochloride 是一种有效的细胞渗透性 Wnt 信号激活剂。 BML-284 诱导 TCF 依赖性转录活性，EC50 为 700 nM。
- GC50489NLS-StAx-hCAS: 2872559-21-0
NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂，IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。
- GC62214FIDAS-3CAS: 1266684-01-8纯度: >99.00%
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A.
- GC62394TeplinovivintCAS: 1428064-91-8纯度: >99.50%
Teplinovivint 是一种有效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性，具有用于肌腱病研究的潜力。
- GC62432β-catenin-IN-2CAS: 1458664-10-2纯度: >99.50%
β-catenin-IN-2 是一种有效的 β-catenin 抑制剂，化合物 H1B1，源于专利 US20150374662A1。β-catenin-IN-2 可用于结直肠癌的研究。
- GC63100N-Desmethylnefopam D5 hydrochloride
N-Desmethylnefopam D5 hydrochloride 是 N-Desmethylnefopam hydrochloride 氘代物。N-Desmethylnefopam hydrochloride 是 Nefopam 的主要代谢产物，是一种中枢性但非阿片类镇痛药，可缓解中度至重度疼痛。
- GC63559ZW4864 free baseCAS: 2632259-92-6
ZW4864 (free base) 是一种具有口服活性和选择性的 β catenin/ B-Cell lymphoma 9 蛋白-蛋白相互作用 (β catenin/BCL9 PPI) 抑制剂。ZW4864 (free base) 抑制 β catenin/BCL9 PPI 的 Ki 值为 0.76 μM，IC50 值为 0.87 μM。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC41534 | FzM1 | 1680196-54-6 | >95.00% | |
An allosteric ligand of Frizzled4 | ||||
| GC42669 | ABC99 | 2331255-53-7 | >95.00% | |
ABC99 是一种N-羟基海因（NHH）-氨基甲酸酯类、不可逆的Wnt去酰基化酶NOTUM选择性抑制剂。 | ||||
| GC43725 | Gallocyanine | 1562-85-2 | >95.00% | |
A Dkk1 inhibitor | ||||
| GC44467 | NSC 668036 | 144678-63-7 | >98.00% | |
An inhibitor of the Dvl PDZ domain | ||||
| GC45354 | 4β-Hydroxywithanolide E | 54334-04-2 | >95.00% | |
A withanolide with anti-inflammatory and anticancer activities | ||||
| GC45596 | YW1128 | 2131223-64-6 | >98.00% | |
An inhibitor of Wnt signaling | ||||
| GC45597 | YW1159 | 2131223-69-1 | >98.00% | |
An inhibitor of Wnt signaling | ||||
| GC46015 | KY 05009 | 1228280-29-2 | >99.50% | |
A TNIK inhibitor | ||||
| GC47372 | Foxy-5 (trifluoroacetate salt) | - | >98.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47570 | Lipoxygenin | 2247911-68-6 | >98.00% | |
An inhibitor of 5-LO | ||||
| GC50077 | WAY 316606 hydrochloride | 1781835-02-6 | - | |
An sFRP-1 inhibitor | ||||
| GC50323 | AMBMP hydrochloride | 2095432-75-8 | - | |
AMBMP hydrochloride 是一种有效的细胞渗透性 Wnt 信号激活剂。 BML-284 诱导 TCF 依赖性转录活性，EC50 为 700 nM。 | ||||
| GC50489 | NLS-StAx-h | 2872559-21-0 | - | |
NLS-StAx-h 是一种 Wnt 信号通路的选择性钉合肽抑制剂，IC50 为 1.4 μM。 NLS-StAx-h 有效抑制 β-连环蛋白-转录因子相互作用。 NLS-StAx-h 抑制结直肠癌细胞的增殖和迁移。 | ||||
| GC50624 | FzM1.8 | 2204290-85-5 | >98.00% | |
FzM1.8 源自 FzM1，是 FZD4 的变构激动剂，pEC50 为 6.4。 FzM1.8 通过在没有任何 WNT 配体的情况下促进 TCF/LEF 转录活性，与 FZD4 结合并激活 WNT/β-连环蛋白途径。 FzM1.8 结合稳定 FZD4，增加对异源三聚体 G 蛋白的亲和力，并刺激 Gβγ 亚基的释放，进而激活 PI3K。 | ||||
| GC60348 | Supinoxin | 888478-45-3 | >99.50% | |
Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶 (P-p68) 的强效口服活性抑制剂，并且是一个一流的抗肿瘤试剂 (anti-cancer agent)。Supinoxin 与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。 Supinoxin 诱导细胞凋亡 (apoptosis) 并抑制 TNBC 癌细胞系的生长，IC50 的范围为 10 nM 至 20 nM。 | ||||
| GC60970 | KY19382 | 2226664-93-1 | >98.00% | |
KY19382 (A3051) is a Wnt/β-catenin signalling activator through inhibitory effects on both CXXC5–DVL interaction and GSK3β activity with IC50s of 19 nM and 10 nM, respectively. | ||||
| GC61093 | MSAB | 173436-66-3 | >99.50% / >99.00% | |
MSAB（methyl 3-{[(4-methylphenyl)sulfonyl]amino}benzoate）是一种选择性Wnt/β-catenin信号抑制剂，与β-catenin结合并促进其降解，其EC 50 为0.583μM。 | ||||
| GC62214 | FIDAS-3 | 1266684-01-8 | >99.00% | |
FIDAS-3 effectively competes against S-adenosylmethionine (SAM) for methionine sadenosyltransferase 2A (MAT2A) binding . FIDAS-3 has anticancer activities by inhibiting the expression of oncogenes. FIDAS-3 is a stilbene derivative and is a potent Wnt inhibitor with an IC50 of 4.9 μM for MAT2A. | ||||
| GC62394 | Teplinovivint | 1428064-91-8 | >99.50% | |
Teplinovivint 是一种有效的 wnt/β-catenin 信号通路抑制剂。Teplinovivint 具有抗炎活性，具有用于肌腱病研究的潜力。 | ||||
| GC62432 | β-catenin-IN-2 | 1458664-10-2 | >99.50% | |
β-catenin-IN-2 是一种有效的 β-catenin 抑制剂，化合物 H1B1，源于专利 US20150374662A1。β-catenin-IN-2 可用于结直肠癌的研究。 | ||||
| GC63100 | N-Desmethylnefopam D5 hydrochloride | - | - | |
N-Desmethylnefopam D5 hydrochloride 是 N-Desmethylnefopam hydrochloride 氘代物。N-Desmethylnefopam hydrochloride 是 Nefopam 的主要代谢产物，是一种中枢性但非阿片类镇痛药，可缓解中度至重度疼痛。 | ||||
| GC63303 | YB-0158 | 1144043-83-3 | - | |
YB-0158 被称为 Wnt 通路抑制剂 2。 | ||||
| GC63465 | KY-02327 | 2093407-25-9 | - | |
KY-02327 是代谢稳定的 KY-02061 类似物，是一种有效的 Dishevelled (Dvl)-CXXC5 相互作用抑制剂。KY-02327 对 Wnt/β-catenin 途径具有激活作用，从而促进成骨细胞分化。 | ||||
| GC63559 | ZW4864 free base | 2632259-92-6 | - | |
ZW4864 (free base) 是一种具有口服活性和选择性的 β catenin/ B-Cell lymphoma 9 蛋白-蛋白相互作用 (β catenin/BCL9 PPI) 抑制剂。ZW4864 (free base) 抑制 β catenin/BCL9 PPI 的 Ki 值为 0.76 μM，IC50 值为 0.87 μM。 | ||||