Wnt/β-catenin
Wnt/β-catenin(Wnt/β-连环蛋白)
β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).
Wnt/β-catenin 相关产品(139)
- GC17764BML-284 (Wnt agonist 1)CAS: 853220-52-7纯度: >99.50%
BML-284 (Wnt agonist 1)是一种Wnt信号通路的强效激动剂，诱导β-catenin和TCF依赖性转录活性的EC 50 值为0.7μM。
- GC17840Cardiogenol C hydrochlorideCAS: 1049741-55-0纯度: >99.50%
Cardiogenol C hydrochloride 是一种有效的细胞渗透性嘧啶诱导剂，可促进 ESC 分化为心肌细胞 (EC50=100 nM)。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC12133 | Windorphen | 19881-70-0 | - | |
Wnt inhibitor | ||||
| GC13301 | TCS 2210 | 1201916-31-5 | - | |
A small molecule inducer of neuronal differentiation | ||||
| GC13582 | KHS 101 hydrochloride | 1784282-12-7 | >98.00% | |
neuronal differentiation inducer | ||||
| GC13978 | JW 74 | 863405-60-1 | >99.00% | |
An inhibitor of TNKS1/2 | ||||
| GC14037 | Triptonide | 38647-11-9 | >99.50% | |
A diterpenoid with diverse biological activities | ||||
| GC14299 | exo-IWR 1 | 1127442-87-8 | - | |
Control for IWR-1-endo | ||||
| GC14546 | IWP-2-V2 | 877618-79-6 | - | |
An inhibitor of Wnt production | ||||
| GC15057 | Kartogenin | 4727-31-5 | >98.00% | |
Kartogenin是软骨样组织形成的诱导剂（EC 50 : 100 nM）。 | ||||
| GC15123 | IDE 1 | 1160927-48-9 | >98.00% | |
An inducer of definitive endoderm from embryonic stem cells | ||||
| GC15753 | WAY-262611 | 1123231-07-1 | >98.00% | |
A Dkk1 inhibitor and Wnt signaling activator | ||||
| GC16013 | IWP 4 | 686772-17-8 | >98.00% | |
An inhibitor of Wnt production | ||||
| GC16320 | Shz 1 | 326886-05-9 | - | |
An activator of cardiac differentiation | ||||
| GC16382 | SKL2001 | 909089-13-0 | >99.50% / >98.00% | |
SKL2001是一种Wnt/β-catenin通路激动剂。SKL2001通过破坏Axin/β-catenin的相互作用稳定细胞内的β-catenin，可用于调控间充质干细胞分化。 | ||||
| GC16701 | SKI II | 312636-16-1 | >99.50% / >98.00% | |
An SPHK1 inhibitor | ||||
| GC16711 | PNU 74654 | 113906-27-7 | >99.00% | |
An inhibitor of β-catenin/Wnt signaling | ||||
| GC16963 | HLY78 | 854847-61-3 | >98.00% | |
A positive modulator of Wnt signaling | ||||
| GC17071 | IWP-3 | 687561-60-0 | - | |
An inhibitor of Wnt production | ||||
| GC17251 | QS 11 | 944328-88-5 | >99.00% | |
An ARFGAP inhibitor | ||||
| GC17606 | CCT251545 | 1661839-45-7 | >99.50% | |
An orally bioavailable inhibitor of Wnt signaling | ||||
| GC17764 | BML-284 (Wnt agonist 1) | 853220-52-7 | >99.50% | |
BML-284 (Wnt agonist 1)是一种Wnt信号通路的强效激动剂，诱导β-catenin和TCF依赖性转录活性的EC 50 值为0.7μM。 | ||||
| GC17782 | Cardionogen 1 | 577696-37-8 | - | |
Wnt signaling modulator | ||||
| GC17840 | Cardiogenol C hydrochloride | 1049741-55-0 | >99.50% | |
Cardiogenol C hydrochloride 是一种有效的细胞渗透性嘧啶诱导剂，可促进 ESC 分化为心肌细胞 (EC50=100 nM)。 | ||||
| GC18291 | PKF118-310 | 84-82-2 | >99.00% | |
An inhibitor of the Tcf4-β-catenin protein interaction | ||||
| GC18595 | G244-LM | 1563007-08-8 | - | |
An inhibitor of Wnt signaling | ||||