GlpBio

Wnt/β-catenin

Wnt/β-catenin(Wnt/β-连环蛋白)

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Wnt/β-catenin 相关产品(139)

  • GC72835 structure
    GC72835NSC260594
    CAS: 906718-66-9
    纯度: >96.00%

    NSC260594诱导细胞凋亡。

  • GC72937 structure
    GC72937Box5
    CAS: 1206604-29-6
    纯度: >98.00%

    Box5是一种强效的Wnt5a拮抗剂。

  • GC73345 structure
    GC73345CDK8-IN-11
    CAS: 2839338-28-0
    纯度: >98.00%

    CDK8-IN-11是一种有效的选择性CDK8抑制剂，IC50值为46 nM。

  • GC73422 structure
    GC73422YW2036
    CAS: 2131223-92-0
    纯度: >99.00%

    YW2036（化合物2a）是一种有效的Wnt/β-Catenin信号通路抑制剂，IC50值为637 nM。

  • GC73573 structure
    GC73573hCA/Wnt/β-catenin-IN-1
    CAS: 3032826-63-1
    纯度: >99.00%

    hCA/Wnt/β-catenin-IN-1 (Compd 15)是hCA的抑制剂（Ki: 33.6, 24.1, 6.8 nM对hCA II， hCA IX, hCA XII） hCA/Wnt/β-catenin-IN-1降低P-gp活性。

  • GC73610 structure
    GC73610F7H
    CAS: 897109-93-2
    纯度: >99.50%

    F7H是卷曲受体FZD7拮抗剂（IC50:1.25μM）。

  • GC73874 structure
    GC73874PTK7/β-catenin-IN-1
    CAS: 906147-24-8
    纯度: 不显示

    PTK7/β-catenin-IN-1（化合物01065）是一种有效的PTK7/β-catenin抑制剂，对PTK7/β-catenin和p53/MDM2的IC50分别为8.9 μM和56.5 μM。

  • GC73875 structure
    GC73875PTK7/β-catenin-IN-2
    CAS: 902434-29-1
    纯度: >96.00%

    PTK7/β-catenin-IN-2（化合物04967）是PTK7/β-catenin的抑制剂。

  • GC73876 structure
    GC73876PTK7/β-catenin-IN-6
    CAS: 1219439-82-3
    纯度: 不显示

    PTK7/β-catenin-IN-6（化合物03653）是PTK7/β-catenin相互作用的抑制剂，其抑制Wnt信号通路，并表现出对癌症（CRC）的抗癌活性。

  • GC73959 structure
    GC73959NF764
    纯度: >99.00%

    NF764是一种有效的β-连环蛋白（CTNNB1）降解剂。

  • GC74320 structure
    GC74320fStAx-35R TFA
    纯度: >97.00%

    fStAx-35R TFA是drocarbon stapped肽。fStAx-35R TFA通过破坏β-catenin-TCF相互作用抑制Wnt/β-catenin信号通路。fStAx-35R TFA可用于癌症研究。

  • GC74321 structure
    GC74321aStAx-35R TFA
    纯度: >98.00%

    aStAx-35R TFA，一种钉状肽，拮抗核形式的β-catenin并抑制Wnt信号传导。

  • GC74343 structure
    GC74343Fz7-21S
    CAS: 2247635-24-9
    纯度: >98.00%

    Fz7-21S是Fz7-21的负对照。

  • GC74412 structure
    GC74412xStAx-VHLL TFA
    纯度: >99.00%

    xStAx-VHLL TFA，一种PROTAC，维持β-catenin的降解，并表现出对Wnt信号传导的强烈抑制。xStAx-VHLL TFA促进β-catenin泛素化。

  • GC74562 structure
    GC74562Ipafricept
    CAS: 1391727-24-4
    纯度: >99.00%

    Ipafricept（OMP-54F28；FZD8-Fc）是一种一流的重组融合蛋白，能结合Wnt配体，阻断Wnt信号传导。

  • GC74579 structure
    GC74579Vantictumab
    CAS: 1345009-45-1
    纯度: >99.00%

    Vantictumab (OMP-18R5)是一种人源IgG2单克隆抗体。

  • GN10017 structure
    GN10017Wogonin
    CAS: 632-85-9
    纯度: >99.50%

    A flavonoid with anti-inflammatory and antitumor activities

  • GC12392 structure
    GC12392LGK-974
    CAS: 1243244-14-5
    纯度: >99.50%

    LGK-974是一种高效且特异的Porcupine（PORCN）抑制剂。

  • GC16640 structure
    GC16640iCRT 14
    CAS: 677331-12-3
    纯度: >99.50%

    An inhibitor of β-catenin-responsive transcription