GlpBio

Wnt/β-catenin

Wnt/β-catenin(Wnt/β-连环蛋白)

β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

Wnt/β-catenin 相关产品(139)

  • GC18734 structure
    GC18734JS-K
    CAS: 205432-12-8
    纯度: >95.00%

    A nitric oxide donor

  • GC18875 structure
    GC18875GSK3β Inhibitor XVIII
    CAS: 1139875-74-3

    An inhibitor of GSK3β

  • GC19144 structure
    GC19144ETC-159
    CAS: 1638250-96-0
    纯度: >98.00%

    A potent, orally bioavailable inhibitor of PORCN

  • GC19198 structure
    GC19198iCRT3
    CAS: 901751-47-1
    纯度: >99.00%

    iCRT3 是 Wnt 和 β-连环蛋白反应性转录的抑制剂。

  • GC19216 structure
    GC19216KYA1797K
    CAS: 1956356-56-1
    纯度: >98.00%

    An inhibitor of Wnt/β-catenin signaling

  • GC19260 structure
    GC19260NCB-0846
    CAS: 1792999-26-8
    纯度: >98.00%

    A TNIK inhibitor

  • GC25603 structure
    GC25603M2912
    CAS: 1460286-21-8

    M2912 (MSC2504877) is a very potent TNKS1/TNKS2 inhibitor (IC50=0.6 nM for TNKS1) with exquisite selectivity over other PARP family enzymes and favorable compound properties. This inhibitor potently modulates the Wnt/β-catenin pathway by elevating the levels of axin2 (EC50=17 nM) and tankyrase in DLD1 cells in a dose-dependent manner resulting in reduced cellular Wnt reporter activity.

  • GC30767 structure
    GC30767Heparan Sulfate
    CAS: 9050-30-0
    纯度: {{1-9}Po-58.0 IU/mg}

    硫酸乙酰肝素 (HS) 是一种复杂的聚阴离子多糖，广泛表达于细胞表面和细胞外基质。

  • GC31663 structure
    GC31663Adavivint (SM04690)
    CAS: 1467093-03-3
    纯度: >98.00% / >99.00%

    Adavivint (SM04690,Lorecivivint) is a potent and specific inhibitor of canonical Wnt signaling with an EC50 of 19.5 nM for inhibiting the TCF/LEF reporter. It is ?150- to 500-fold more potent than the other known Wnt inhibitors across multiple cellular assays.

  • GC31717 structure
    GC31717Ginkgetin
    CAS: 481-46-9
    纯度: >98.00% / >98.50%

    Ginkgetin一种从银杏叶中提取的双黄酮类天然化合物，能够抑制Wnt信号通路（IC₅₀=5.92μM）。

  • GC31794 structure
    GC31794Methyl vanillate
    CAS: 3943-74-6
    纯度: >99.00%

    Methyl Vanillate, one of the ingredients in Hovenia dulcis Thunb, activates the Wnt/β-catenin pathway and induces osteoblast differentiation in vitro.

  • GC32698 structure
    GC32698Pyrvinium pamoate (Pyrvinium embonate)
    CAS: 3546-41-6
    纯度: >98.00%

    An anthelmintic and anticancer agent

  • GC32763 structure
    GC32763LF3
    CAS: 664969-54-4
    纯度: >99.50%

    An inhibitor of the β-catenin-TCF4 protein-protein interaction

  • GC32914 structure
    GC32914EMT inhibitor-1
    CAS: 1638526-21-2
    纯度: >99.00%

    EMTinhibitor-1是Hippo，TGF-β和Wnt信号通路的抑制剂，并拥有抗肿瘤活性。

  • GC32923 structure
    GC32923KY1220
    CAS: 292168-79-7
    纯度: >99.00% / >98.00%

    KY1220 is a small molecule that destabilizes both β-catenin and Ras, via targeting the Wnt/β-catenin pathway with IC50 of 2.1 μM in HEK293 reporter cells.

  • GC33304 structure
    GC33304Gigantol
    CAS: 67884-30-4
    纯度: >99.50%

    Gigantol是一种来自几种药用兰花的联苄基化合物。Gigantol对癌症有潜在治疗价值。Gigantol是Wnt/β-catenin通路的抑制剂。

  • GC34628 structure
    GC34628IWP-O1
    CAS: 2074607-48-8
    纯度: >99.00%

    IWP-O1 is a porcn inhibitor with an EC50 value of 80 pM in a cultured cell reporter assay of Wnt signaling and effectively suppresses the phosphorylation of Dvl2/3 in HeLa cells.

  • GC34980 structure
    GC34980(E)-Ferulic acid
    CAS: 537-98-4
    纯度: >99.00%

    Trans-ferulic acid is a potent activator of AMPKunder high glucose condition.

  • GC35873 structure
    GC35873DK419
    CAS: 2102672-22-8
    纯度: >99.50%

    DK419 是一种有效、可口服的 Wnt/β-catenin 信号通路抑制剂，IC50 值为 0.19 μM。DK419 能降低 Axin2，β-catenin，c-Myc，Cyclin D1 和 Survivin 能够改变细胞内耗氧率，诱导 pAMPK 的产生。

  • GC36073 structure
    GC36073Foxy-5
    CAS: 881188-51-8

    A Wnt5a peptide mimetic

  • GC36483 structure
    GC36483L-Quebrachitol
    CAS: 642-38-6
    纯度: >95.00%

    L-Quebrachitol (L-QCT), a natural product isolated from many plants, promotes proliferation and cell DNA synthesis. L-Quebrachitol upregulates bone morphogenetic protein-2 (BMP-2) and runt-related transcription factor-2 (Runx2) and regulatory genes associated with mitogen-activated protein kinase (MAPK) and Wnt/β-catenin signaling pathway, while down-regulating the receptor activator of the nuclear factor-κB(NF-κB) ligand (RANKL) mRNA level.

  • GC37937 structure
    GC37937Wnt/β-catenin agonist 1
    CAS: 2305372-67-0

    Wnt/β-catenin agonist 1 (compound 3f) 是 Wnt/β-catenin 信号通路的一个激动剂，EC50 值为 0.27 μM。

  • GC39159 structure
    GC39159Tegatrabetan
    CAS: 1227637-23-1

    Tegatrabetan (BC2059) is an antagonist of β-Catenin. Tegatrabetan (BC2059) treatment disrupts the binding of β-catenin with the scaffold protein transducin β-like 1 (TBL1) and proteasomal degradation and declines in the nuclear levels of β-catenin.

  • GC39266 structure
    GC39266Hematein
    CAS: 475-25-2
    纯度: >65.00%

    Hematein inhibits casein kinase II activity in a selective, dose-dependent and ATP non-competitive manner in vitro, with IC50 of 0.55 μM in the presence of 10 μM ATP.