GlpBio

YB-0158

目录号: GC63303纯度: >98%同义词: Wnt pathway inhibitor 2
COASDSData Sheet
YB-0158 被称为 Wnt 通路抑制剂 2。
YB-0158
Cas No.: 1144043-83-3
规格价格库存数量操作
5 mg¥6,380.00现货
1
10 mg¥10,200.00现货
1
50 mg¥35,620.00现货
1
100 mg¥57,000.00现货
1
电话: 400-920-5774Email: sales@glpbio.cn

文献被引

本产品暂无引用记录;以下为 GlpBio 产品在 Nature / Cell / Science 等顶刊的客户引用样例
  • Nature cover
    Nature
    641, 529–536 (2025)
  • Nature cover
    Nature
    628, 630–638 (2024)
  • Nature cover
    Nature
    632, 686–694 (2024)
  • Nature cover
    Nature
    618, 1017–1023 (2023)
  • Nature cover
    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
  • Science cover
    Science
    387(6739) (2025)
  • Science cover
    Science
    387(6734) (2025)
  • Cell Research cover
    Cell Research
    35, 97–116 (2025)
  • Cell Research cover
    Cell Research
    34, 683–706 (2024)
  • Cell Research cover
    Cell Research
    33, 273–287 (2023)
  • Cell Research cover
    Cell Research
    33, 546–561 (2023)
  • Cell Research cover
    Cell Research
    33, 904–922 (2023)
  • Cell Research cover
    Cell Research
    31, 1291–1307 (2021)

产品描述 Description

YB-0158 is known as Wnt pathway inhibitor 2. YB-0158 is a peptidomimetic structure with high predicted affinity for Sam68 [1].

YB-0158 elicits a cancer-selective response impeding main cancer stem cell hallmarks [1].

YB-0158 displayed enhanced selective toxicity in colorectal cancer models vs. normal intestinal epithelium progenitor cells. YB-0158 exert negative impact on cancer cell growth by inducing apoptosis and reducing proliferation. YB-0158 eradicated CSCs activity in vivo by a syngeneic mouse-to-mouse serial transplantation assay [2].

References:
[1]. Angelique N. Masibag, Christopher J. Bergin, Joshua R. Haebe, A?cha Zouggar, Muhammad S. Shah, Tamara Sandouka, Amanda Mendes da Silva, Fran?ois M. Desrochers, Aube Fournier-Morin, Yannick D. Benoit.Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience, Volume 24, Issue 12, 17 December 2021, Pages 103442
[2]. Masibag, Angelique Noelline. Characterization of a New Peptidomimetic Compound Modulating Sam68 Functions in Human Colon Cancer Stem Cells. Diss. Université d'Ottawa/University of Ottawa, 2021.

YB-0158 被称为 Wnt 通路抑制剂 2。YB-0158 是一种拟肽结构，对 Sam68 [1] 具有高预测亲和力。

YB-0158 引发癌症选择性反应，阻碍主要的癌症干细胞标志[1]。

与正常肠上皮祖细胞相比，YB-0158 在结直肠癌模型中表现出增强的选择性毒性。 YB-0158 通过诱导细胞凋亡和减少增殖对癌细胞生长产生负面影响。 YB-0158 通过同源小鼠对小鼠连续移植试验在体内根除 CSCs 活性[2]。

实验参考方法 Experimental Reference Method

Cell experiment [1]:

Cell lines

HT29 cells

Preparation Method

Cells were treated with DMSO or YB-0158 for 48 hours. As a positive control, each cell line was treated with 1 µM of staurosporine for 6 h.

Reaction Conditions

0.2, 0.5µM for 48 hours

Applications

EdU incorporation confirmed that lower doses of YB-0158 were sufficient to significantly decrease proliferation in human CRC cells. When used at 0.5 µM, YB-0158 also significantly increased apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays
Animal experiment [1]:

Animal models

C57BL/6 mice accepted subcutaneous injection of MC38 cells into the flanks

Preparation Method

Seven days post-injection, daily doses of YB-0158 (100mg/kg), or control saline (HBSS vehicle) were intraperitoneally injected in tumor-bearing animals for 14 days.

Dosage form

Intraperitoneal injection, 100mg/kg

Applications

No significant differences in primary tumor size were observed upon either YB-0158 in vivo treatments versus saline controls, residual secondary tumors from YB-0158-treated group were significantly smaller versus matched saline controls.

References:

[1]: Angelique N. Masibag, Christopher J. Bergin, Joshua R. Haebe, AÏcha Zouggar, Muhammad S. Shah, Tamara Sandouka, Amanda Mendes da Silva, FranÇois M. Desrochers, Aube Fournier-Morin, Yannick D. Benoit.Pharmacological targeting of Sam68 functions in colorectal cancer stem cells. iScience, Volume 24, Issue 12, 17 December 2021, Pages 103442

产品文档 Product Documents

Purity:>98%
COASDSData Sheet

化学性质Chemical Properties

CAS 号
1144043-83-3
同义词
Wnt pathway inhibitor 2
分子式
C32H32N7Na2O7P
分子量
703.59 g/mol
溶解性
DMSO : 100 mg/mL (142.13 mM; Need ultrasonic)|Water : < 0.1 mg/mL (ultrasonic;adjust pH to 1 with 1M HCl) (insoluble)
保存条件
Store at -20°C
General tips
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
为了提高溶解度，请将管子加热至 37°C，然后在超声波浴中震荡一段时间。
Shipping Condition
评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备 RT，或根据请求配备蓝冰。

计算工具摩尔浓度 / 稀释 / 分子量 / 单位换算 / 体内配方 / 溶解度

g/mol