Salinomycin sodium salt is a macrocyclic polyether ionophore antibiotic produced by the fermentation of Streptomyces albus[1-2]. Salinomycin sodium salt is used in research for the prevention and treatment of coccidiosis in livestock and poultry, as well as for anticancer studies[3-4].
In vitro, Salinomycin sodium salt (0.1–40μM) was combined with Doxorubicin to treat feline injection-site sarcoma C10 cells and squamous cell carcinoma SCCF1 cells for 48 hours. Salinomycin sodium salt significantly enhanced the cytotoxicity of doxorubicin, demonstrating a synergistic effect in both C10 and SCCF1 cells[5]. Salinomycin sodium salt (1μM) was used to treat human melanoma SK-Mel-19 cells for 24 hours. Salinomycin sodium salt induced a decrease in mitochondrial membrane potential and endoplasmic reticulum stress by inhibiting autophagic flux, leading to autophagic cell death[6].
In vivo, Salinomycin sodium salt (20mg/kg/day) was orally administered to Cd-exposed mice starting 15 days after Cd exposure, once daily for 14 consecutive days. Salinomycin sodium salt significantly reduced Cd accumulation in the liver and kidneys, restored hepatic and renal function markers, and alleviated histopathological damage in the liver[7]. Salinomycin sodium salt (16mg/kg/day) was orally administered to Pb-exposed mice starting 15 days after Pb exposure, once daily for 14 consecutive days. Salinomycin sodium salt significantly reduced abnormal elevations of magnesium and phosphorus in the brain and mitigated Pb-induced neuronal necrosis and histopathological changes in brain tissue[8].
References:
[1] Qi D, Liu Y, Li J, et al. Salinomycin as a potent anticancer stem cell agent: State of the art and future directions. Med Res Rev. 2022 May;42(3):1037-1063.
[2] Dewangan J, Srivastava S, Rath SK. Salinomycin: A new paradigm in cancer therapy. Tumour Biol. 2017 Mar;39(3):1010428317695035.
[3] Jiang J, Li H, Qaed E, et al. Salinomycin, as an autophagy modulator-- a new avenue to anticancer: a review. J Exp Clin Cancer Res. 2018 Feb 13;37(1):26.
[4] Antoszczak M, Huczyński A. Anticancer Activity of Polyether Ionophore-Salinomycin. Anticancer Agents Med Chem. 2015;15(5):575-91.
[5] Borlle L, Dergham A, Wund Z, et al. Salinomycin decreases feline sarcoma and carcinoma cell viability when combined with doxorubicin. BMC Vet Res. 2019 Jan 24;15(1):36.
[6] Liu Y, Hao Y, Li Y, et al. Salinomycin induces autophagic cell death in salinomycin-sensitive melanoma cells through inhibition of autophagic flux. Sci Rep. 2020 Oct 28;10(1):18515.
[7] Kamenova K, Gluhcheva Y, Vladov I, et al. Ameliorative effect of the anticancer agent salinomycin on cadmium-induced hepatotoxicity and renal dysfunction in mice. Environ Sci Pollut Res Int. 2018 Feb;25(4):3616-3627.
[8] Petrova E, Gluhcheva Y, Pavlova E, et al. Effects of Salinomycin and Deferiprone on Lead-Induced Changes in the Mouse Brain. Int J Mol Sci. 2023 Feb 2;24(3):2871.
Salinomycin sodium salt是一种由Streptomyces albus发酵产生的大环聚醚离子载体抗生素 [1-2]。Salinomycin sodium salt可用于畜禽养殖中防治球虫病以及抗癌的相关研究[3-4]。
在体外，Salinomycin sodium salt（0.1-40μM）联合多柔比星处理猫注射部位肉瘤细胞C10和鳞状细胞癌SCCF1细胞48小时，Salinomycin sodium salt显著增强多柔比星的细胞毒性，在C10和SCCF1细胞中表现为协同效应 [5]。Salinomycin sodium salt（1μM）处理人黑色素瘤SK-Mel-19细胞24小时，Salinomycin sodium salt通过抑制自噬流诱导线粒体膜电位下降和内质网应激，导致自噬性细胞死亡[6]。
在体内，Salinomycin sodium salt（20mg/kg/day）口服处理Cd暴露小鼠（从Cd暴露后第15天开始，连续14天），Salinomycin sodium salt显著降低肝脏和肾脏中的Cd蓄积，恢复肝肾功能指标，并改善肝组织病理学损伤[7]。Salinomycin sodium salt（16mg/kg/day）口服处理Pb暴露小鼠（从Pb暴露后第15天开始，连续14天），Salinomycin sodium salt显著降低脑组织中镁和磷的异常升高，并减轻Pb诱导的神经元坏死和脑组织病理学变化[8]。