Dendrophenol (Moscatilin) is from Dendrobium nobile, a naturally occurring bibenzyl compound with potential antimutagenic activity. Dendrophenol (Moscatilin) almost completely suppresses (97%) the AFB1-induced SOS response with an IC50 of 0.08 μM.
Dendrophenol induces apoptosis of colorectal HCT-116 cells via tubulin depolymerization and DNA damage stress and that this leads to the activation of JNK and mitochondria-involved intrinsic apoptosis pathway.[2]
In Male severe combined immunodeficient mice implanted with HCT-116 cells, the i.p. treatment with dendrophenol causes a significant inhibition of tumor growth without the loss of body weight.[2]
[1] Miyazawa M, et al. J Agric Food Chem. 1999 May;47(5):2163-7. [2] Chen TH, et al. Clin Cancer Res. 2008 Jul 1;14(13):4250-8.