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Home >> Signaling Pathways >> Proteases >> Endogenous Metabolite

Endogenous Metabolite(内源性代谢物)

Metabolite results when a drug is metabolized into a modified form which continues to produce effects. A metabolome in a given body fluid is influenced by endogenous factors such as age, sex, body composition and genetics as well as underlying pathologies.The levels of the enormous array of unique small-molecule metabolites are usually kept tightly regulated by the activity of a very large array of enzymes and transporters responsible for the production, transformation, degradation, and compartmentalization of these small molecules.The levels of the endogenous small molecules present in the brain are normally tightly regulated.

Products for  Endogenous Metabolite

  1. Cat.No. 产品名称 Information
  2. GC44795 Miquelianin (Quercetin 3-O-glucuronide)

    槲皮素3-O-葡萄糖酸苷,Quercetin 3-O-glucuronide; Quercetin 3-glucuronide

     Miquelianin (Quercetin 3-O-glucuronide)是槲皮素在体内的主要代谢产物，也是羰基还原酶1（CBR1）的抑制剂。
  3. GC44793 Pyrroloquinoline quinone

    吡咯喹啉醌; PQQ; Methoxatin

     据报道，吡咯并喹啉醌是一种新的哺乳动物乳酸脱氢酶 (LDH) 辅酶。
  4. GC44785 Pyridoxal 5'-phosphate (hydrate)

    3-羟基-2-甲基-5-磷酰氧甲基-4-吡啶甲醛,Pyridoxal phosphate hydrate

     An enzyme cofactor
  5. GC44680 Pregnenolone sulfate (sodium salt)

    3β-Hydroxy-5-pregnen-20-one monosulfate sodium

     Pregnenolone sulfate (sodium salt)是一种孕烯醇酮的神经活性代谢产物，对氨基丁酸A型受体（GABAAR）的IC50值为26±2μmol/L，对不含γ亚基的GABAAR的IC50值为18±3μmol/L。
  6. GC44635 Phosphoenolpyruvic Acid (potassium salt)

    磷酸烯醇式丙酮酸钾; Potassium 1-carboxyvinyl hydrogenphosphate

     An enzyme substrate for glycolysis and gluconeogenesis pathways
  7. GC44592 Pentacosanoic Acid

    二十五烷酸

     A saturated long-chain fatty acid
  8. GC44551 Palmitoyl-L-carnitine (chloride)

    L-氯化棕榈酰肉碱

     A long-chain acylcarnitine
  9. GC44550 Palmitoyl-D-carnitine (chloride)

    CAR 16:0, C16:0 Carnitine, D-Carnitine hexadecanoyl ester, D-Carnitine palmitoyl ester, D-Hexadecanoylcarnitine, Hexadecanoyl-D-carnitine, D-Palmitoylcarnitine

     A long-chain acylcarnitine
  10. GC44490 Octanoyl-L-carnitine (chloride)

    C8 Carnitine

     A medium-chain acylcarnitine
  11. GC44307 NADP+

    烟酰胺腺嘌呤双核苷酸磷酸盐,Coenzyme II, β-NADP, Nicotinamide adenine dinucleotide phosphate, TPN

     NADP+ 是电子供体烟酰胺腺嘌呤二核苷酸磷酸的氧化形式。
  12. GC44284 N1,N8-Diacetylspermidine (hydrochloride)

    NSC 685959

     An acetyl derivative of spermidine
  13. GC44262 Myristoyl-L-carnitine (chloride)

    L-Myristoylcarnitine

     A long-chain acylcarnitine
  14. GC44079 L-Leucyl-L-Leucine methyl ester (hydrochloride)

    LLOMe hydrochloride; Leu-Leu methyl ester hydrochloride; H-Leu-Leu-OMe hydrochloride

     L-Leucyl-L-Leucine methyl ester (hydrochloride)是一种溶酶体缩合产物，对自然杀伤细胞和CD4+及CD8+ T淋巴细胞具有细胞毒性，但不影响辅助性T细胞和B细胞。
  15. GC44061 L-Homoarginine (hydrochloride)

    L-高精氨酸盐酸盐

     An uncompetitive inhibitor of alkaline phosphatases
  16. GC44044 Lauroyl-L-carnitine (chloride)

    L-氯化月桂酰肉碱

     月桂基-l-肉碱是一种天然存在的化合物，属于酰基肉碱家族。
  17. GC44029 L-Alanyl-L-Glutamine

    L-丙氨酸-L-谷氨酰胺

     A synthetic glutamine dipeptide
  18. GC44019 L-(+)-Ergothioneine

    麦角硫因; L-(+)-Ergothioneine

     L-(+)-Ergothioneine是一种含硫的组氨酸衍生物，是一种有效的抗氧化剂。
  19. GC43922 Isovaleryl-L-carnitine (chloride)

    L-异戊酰基肉碱

     Isovaleryl-L-carnitine (chloride)是L-肉碱的类似物，可延迟小鼠C2.8肝细胞中起始的凋亡细胞死亡。
  20. GC43904 Inosine 5'-triphosphate (sodium salt)

    三磷酸肌苷三钠盐

     A nucleoside triphosphate
  21. GC43903 Indoxyl Sulfate (potassium salt)

    硫酸吲哚钾盐

     硫酸吲哚酚(Indoxyl sulfate (IS)),又称3-吲哚酚硫酸和3-吲哚酚硫酸,是膳食l -色氨酸的代谢物,具有心脏毒素和尿毒症毒素的作用。
  22. GC43901 Indole-3-Acetic Acid (sodium salt)

    1H-吲哚-3-羧酸（吲哚乙酸）,Indole-3-acetic acid sodium; 3-IAA sodium

     A plant growth regulator
  23. GC43876 Hydroxy Bosentan

    波生坦羟甲基杂质,Ro 48-5033

     A metabolite of bosentan
  24. GC43820 Hexadecanal

    十六醛,Palmitaldehyde

     A free fatty aldehyde analog of palmitic acid
  25. GC43776 Glycochenodeoxycholic Acid (sodium salt)

    甘氨鹅脱氧胆酸钠; Chenodeoxycholylglycine sodium salt; Sodium glycochenodeoxycholate

     A primary bile acid
  26. GC43498 DL-α-Lipoic Acid

    α-硫辛酸; Thioctic acid; (±)-α-Lipoic acid; DL-α-Lipoic acid

     An important decarboxylation cofactor and antioxidant
  27. GC43490 DL-Glyceraldehyde-3-phosphate

    DL-甘油醛3-磷酸

     DL-甘油醛-3-磷酸是冬氨酸氨基转移酶阳离子和阴离子同工酶的一种时间依赖性抑制剂。
  28. GC43434 D-Glucose-6-phosphate (sodium salt)

    D-葡萄糖-6-磷酸

     D-Glucose-6-phosphate (sodium salt)是葡萄糖代谢的基本组成部分，是葡萄糖被己糖激酶（或葡萄糖激酶）磷酸化或葡萄糖-1-磷酸被磷酸葡糖变位酶转化时在细胞中形成的，这是糖原合成的第一步。
  29. GC43432 D-Glucosamine-2-sulfate (sodium salt)

    氨基葡萄糖硫酸钠盐

     D-Glucosamine-2-sulfate（钠盐）是一种内源性代谢物。
  30. GC43431 D-Fructose-6-phosphate (sodium salt)

    D-果糖-6-磷酸二钠

     D-Fructose-6-phosphate (sodium salt)是一种内源性代谢物，是糖酵解和磷酸戊糖途径的中间产物。
  31. GC43403 Dehydroepiandrosterone Sulfate (sodium salt)

    去氢表雄酮硫酸钠,Sodium prasterone sulfate

     A steroid precursor
  32. GC43393 Decanoyl-L-carnitine (chloride)

    L-癸酰氯化肉碱

     A derivative of L-carnitine
  33. GC43367 D-(+)-Glucose-13C6

    13C6-葡萄糖,Glucose-13C6; D-(+)-Glucose-13C6; Dextrose-13C6

     D-(+)-Glucose-13C6是D-(+)-Glucose的稳定同位素标记对应物，主要用作定量 D-(+)-Glucose的内标，通过GC-或LC-MS测量。
  34. GC43355 Cytidine 5'-triphosphate (sodium salt)

    三磷酸胞苷二钠,NSC 20261

     Cytidine 5͇-三磷酸（钠盐）是一种内源性代谢物。
  35. GC43323 Creatine Phosphate (potassium salt)

    Phosphocreatine

    磷酸肌酸（钾盐）主要存在于脊椎动物的骨骼肌中，是一种称为 α 氨基酸和衍生物的有机化合物，是测定肌酸激酶的底物，用于在骨骼肌收缩过程中再生 ATP。
  36. GC43296 Coenzyme B12

    腺苷钴胺; Coenzyme B12; Cobamamide; AdoCbl

    A biologically active form of vitamin B12
  37. GC43261 Cholesteryl Myristate

    胆固醇肉豆蔻酸; Cholesteryl myristate; Cholesteryl tetradecanoate

     A cholesterol ester
  38. GC43257 Cholesteryl Eicosapentaenoate

    20:5 Cholesteryl ester

     A cholesterol ester
  39. GC43251 Cholesterol Sulfate (sodium salt)

    胆固醇硫酸酯钠盐

    硫酸胆固醇（Cholesterol Sulfate (sodium salt)) 于 1965 年首次从人体血浆中分离出来，浓度为 300 μg/100 ml 。
  40. GC43000 Butyryl-L-carnitine (chloride)

    R-丁酰基肉碱

     A butyrate ester of carnitine
  41. GC42846 Arachidonoyl-L-carnitine (chloride)

    C20:4 Carnitine​

    A C20:4 acylcarnitine
  42. GC42697 Acetyl Coenzyme A (sodium salt)

    乙酰辅酶A钠盐; Acetyl-CoA trisodium

     乙酰辅酶A钠盐（Acetyl Coenzyme A (sodium salt)）是酶促乙酰基转移反应中必需的辅因子和酰基载体。Acetyl Coenzyme A 可作为组蛋白乙酰酶（HAT）的乙酰基供体，用于组蛋白和非组蛋白的翻译后乙酰化反应。
  43. GC42562 5-Methyl-2'-deoxycytidine

    5-甲基-2'-脱氧胞苷,5-Methyldeoxycytidine

     A pyrimidine nucleoside
  44. GC42484 5,6-dihydroxy Indole

    5,6-二羟基吲哚

     An intermediate in melanogenesis
  45. GC42410 4-hydroxy Nonenal

    4-羟基壬烯醛,4-HNE

     4-羟基壬烯醛（4-hydroxy Nonenal，4-HNE）是一种脂质过氧化（LPO）产物，是一种α，β不饱和羟基烯醛，由ω-6多不饱和脂肪酸氧化形成，它是一种无色油。
  46. GC42201 3,3'-Diiodo-L-thyronine

    3,3'-二碘甲腺原氨酸,3,3'-T2

     A metabolite of thyroid hormone
  47. GC42150 2'-Deoxycytidine 5'-diphosphate (sodium salt hydrate)

    2'-脱氧胞苷-5'-二磷酸三钠盐,dCDP trisodium

     A nucleotide diphosphate
  48. GC42000 TRIA-662 (1-Methylnicotinamide chloride)

    3-氨基甲酰-1-甲基氯化吡啶,1-Methylnicotinamide chloride; N-methylnicotinamide chloride

     TRIA-662 (1-Methylnicotinamide chloride)是烟酰胺经烟酰胺N-甲基转移酶（NNMT）催化生成的主要代谢产物。
  49. GC41999 1-Methylhistamine (hydrochloride)

    1-甲基组胺二对甲苯磺酸盐

     1-Methylhistamine (hydrochloride)是一种由组胺经组胺-N-甲基转移酶（HNMT）催化产生的主要代谢产物，用于评估体内组胺的代谢水平。
  50. GC41825 1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)

    1,2-Dipalmitoyl-sn-glycero-3-phosphatidic Acid, 1,2-Dipalmyitoyl-sn-glycero-3-phophate, 1,2-DPPA, 16:0/16:0-PA

     1,2-Dipalmitoyl-sn-glycero-3-phosphate (sodium salt)（16:0/16:0-PA）是一种磷脂，含有插入到sn-1和sn-2位置的长链（16:0）棕榈酸，能够用于制备脂质体、胶束和人工膜。
  51. GC41804 1,2-Dimyristoyl-sn-glycero-3-PE

    1,2-十四酰基磷脂酰乙醇胺

     A phospholipid

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