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Home >> Signaling Pathways >> Endocrinology and Hormones >> Androgen Receptor

Androgen Receptor(雄激素受体)

AR (androgen receptor) is a member of steroid hormone receptor and ligand-activated transcription factor. It plays a crucial role in prostate cellular proliferation and male sexual differentiation.

Products for  Androgen Receptor

  1. Cat.No. 产品名称 Information
  2. GC62118 ARV-110

    ARV-110

     ARV-110是一种具有口服生物利用度的特异性雄激素受体（AR）PROTAC降解剂，可导致AR的泛素化和降解。
  3. GC62106 JNJ-63576253

    TRC-253

     JNJ-63576253 (TRC-253) is a potent and selective androgen receptor (AR) Antagonist with IC50 of 6.9 nM. JNJ-63576253 displays robust inhibition in WT and LBD-mutated, enzalutamide-resistant models of prostate cancer.
  4. GC62061 Melengestrol acetate

    醋酸美伦孕酮

     A synthetic progestogen
  5. GC61971 Liarozole

    利阿唑,R75251

     A CYP26A1 inhibitor
  6. GC61850 Medroxyprogesterone acetate D3

    醋酸甲羟孕酮 D3; Medroxyprogesterone 17-acetate-d3; Farlutin-d3

     Medroxyprogesterone acetate D3 是 Medroxyprogesterone acetate 的氘代物。Medroxyprogesterone acetate 是一种广泛使用的合成类固醇，与孕酮 (progesterone)，雄激素 (androgen) 和糖皮质激素受体 (glucocorticoid receptors) 都有作用。
  7. GC61491 (R)-Bicalutamide

    (R)-比卡鲁胺

     (R)-Bicalutamide是Bicalutamide的R型对映体。(R)-Bicalutamide是一种雄激素受体(AR)拮抗剂，具有抗肿瘤活性。(R)-Bicalutamide广泛用于前列腺癌的研究。
  8. GC61481 PROTAC AR Degrader-4 TFA PROTACARDegrader-4包含cIAP1配体结合基团，linker和雄激素受体(AR)配体结合基团。基于cIAP1的降解剂也被称为SNIPER。
  9. GC48880 7-Methoxyflavone

    7-甲氧基黄酮

     A flavone with diverse biological activities
  10. GC48831 Flutamide-d7

    SCH 13521-d7

     Flutamide-d7 是氘标记的氟他胺。
  11. GC48808 5β-Androstane-3α,17β-diol

    5β-Adiol, 5β-Androstanediol, β-Androstane-3α,17β-diol, Etiocholanediol

     A metabolite of testosterone
  12. GC48724 Pregnanetriol

    孕三醇

     A metabolite of 17α-hydroxyprogesterone
  13. GC47674 Mifepristone-d3

    RU486-d3; RU 38486-d3

     A neuropeptide with diverse biological activities
  14. GC47554 Letrozole-d4

    来曲唑 d4

     An internal standard for the quantification of letrozole
  15. GC47231 Dimethomorph

    烯酰吗啉

     A morpholine fungicide
  16. GC47215 Dienogest-d8 An internal standard for the quantification of dienogest
  17. GC47159 Cyprodinil

    嘧菌环胺

     An anilinopyrimidine fungicide
  18. GC46925 Bicalutamide-d4

    比卡鲁胺 d4

     An internal standard for the quantification of bicalutamide
  19. GC46777 AC-262536

    4-(3-内型-羟基-8-氮杂双环[3.2.1]辛烷-8-基)萘-1-甲腈

    A selective androgen receptor modulator
  20. GC46775 Abiraterone Acetate-d4

    CB7630-d4

     醋酸阿比特龙-d4 (CB7630-d4) 是氘标记的醋酸阿比特龙。醋酸阿比特龙 (CB7630) 是一种口服的、有效的、选择性的、不可逆的 CYP17A1 抑制剂，具有抗雄激素活性。醋酸阿比特龙是阿比特龙 (CB7598) 的前药形式。
  21. GC46471 17β-hydroxy Exemestane-d3 A neuropeptide with diverse biological activities
  22. GC46456 16α-Hydroxyetiocholanolone A metabolite of 16α-DHEA and androstenedione
  23. GC60589 Apalutamide D4

    ARN-509-d4

     ApalutamideD4(ARN-509D4)是Apalutamide的一种氘代化合物。Apalutamide是有效，竞争性的雄激素受体(AR)拮抗剂，IC50为16nM。
  24. GC39451 Testosterone (propionate)

    丙酸睾丸素

     An Analytical Reference Standard
  25. GC45935 Testosterone

    睾酮

    An Analytical Reference Standard
  26. GC45530 Norgestrel-d6

    左炔诺孕酮 d6

     An internal standard for the quantification of norgestrel
  27. GC37687 Stanolone benzoate

    17-安息香酸雄甾醇酮

     Stanolone benzoate (Androstanolone benzoate) 是一种合成的雄激素和合成代谢类固醇。
  28. GC36981 PROTAC AR Degrader-4 PROTAC AR Degrader-4 包含 cIAP1 配体结合基团，linker 和雄激素受体 (AR) 配体结合基团。基于 cIAP1 的降解剂也被称为 SNIPER。
  29. GC36820 Ostarine Ostarine (GTx-024, MK-2866, Enobosarm) is a selective androgen receptor modulator (SARM) with Ki of 3.8 nM, and is tissue-selective for anabolic organs. Phase 3.
  30. GC36621 MK-0773

    PF-05314882

     MK-0773 是一种选择性雄激素受体调节剂 (selective androgen receptor modulators)，与 AR 结合，IC50 值为 6.6 nM。
  31. GC36344 Isosilybin B

    异水飞蓟宾B

     Isosilybin B，一种从 silymarin 中分离的黄酮木脂素，具有抗前列腺癌 (PCA) 活性，抑制癌细胞增殖，诱导 G1 期阻滞和凋亡。Isosilybin B 引起雄激素受体降解。
  32. GC35541 Boldenone Undecylenate

    宝丹酮十一烯酸酯

     An Analytical Reference Standard
  33. GC35534 BMS-564929 BMS-564929 是一种 雄激素受体 (AR) 激动剂，结合到雄激素受体，Ki 为 2.11±0.16 nM。
  34. GC35069 2,2,5,7,8-Pentamethyl-6-Chromanol

    3,4-二氢-2,2,5,7,8-五甲基-2H-1-苯并吡喃-6-酚,PMC

     2,2,5,7,8-Pentamethyl-6-Chromanol (PMC) 是维生素 E (α-tocopherol) 的抗氧化部分。2,2,5,7,8-Pentamethyl-6-Chromanol 具有有效的雄激素受体 (androgen receptor) 信号调节和抗前列腺癌细胞系的抗癌活性。
  35. GC45239 δ4-Abiraterone

    阿比特龙代谢物,Δ4-Abiraterone; CB-7627; Abiraterone D4A metabolite

     An active metabolite of abiraterone
  36. GC44861 S-23

    (S)-2-(芴甲氧羰基)-3-联苯基氨基丙酸

     A selective androgen receptor modulator
  37. GC44686 Prochloraz

    咪鲜胺; BTS 40542

    An imidazole antifungal
  38. GC44527 p,p'-DDE

    2，2-双（4-氯苯基）-1，1-二氯乙烯,4,4'-DDE; p,p'-Dichlorodiphenyldichloroethylene

     A metabolite and degradation product of the pesticide DDT
  39. GC44405 Nilutamide

    尼鲁米特,Nilandron; RU 23908

     A non-steroidal androgen receptor antagonist
  40. GC44363 Neoaureothin

    NSC 260179, Spectinabilin

     A bacterial metabolite
  41. GC41300 17β-hydroxy Exemestane

    亚甲基宝丹酮

     An active metabolite of exemestane
  42. GC41153 Tibolone

    替勃龙

     Tibolone是一种合成类固醇，具有弱雌激素、孕激素及雄激素活性。
  43. GC40528 11α-hydroxy Testosterone A CYP3A metabolite of testosterone
  44. GC34887 Androstanolone acetate

    雄诺龙醋酸酯

     Androstanoloneacetate是一种雄激素配体，靶向作用于雄激素受体α(AR)。Androstanoloneacetate通过连接桥与cIAP1配体Bestatin结合从而形成PROTAC分子。
  45. GC34005 Dehydroisoandrosterone 3-acetate (Dehydroepiandrosterone 3-acetate)

    醋酸去氢表雄酮; Dehydroepiandrosterone 3-acetate; DHEA acetate

     Dehydroepiandrosterone 3-acetate 是一种睾酮/雌激素前体和已知的脊椎动物攻击性调节剂。
  46. GC33224 Proxalutamide (GT0918)

    GT0918; Pruxelutamide

     Proxalutamide (GT0918)是一种新型的、具有口服活性的雄激素受体（AR）拮抗剂，Proxalutamide可下调TMPRSS2和ACE2的表达来抑制病毒进入宿主细胞，同时通过激活Nrf2通路以减少炎症。
  47. GC32908 UT-155 UT-155是一种选择性的、有效的雄激素受体(AR)拮抗剂，与AR-LBD结合的Ki值为267nM。
  48. GC32907 N-desmethyl Enzalutamide (N-desmethyl MDV 3100)

    4-[3-[4-氰基-3-(三氟甲基)苯基]-5,5-二甲基-4-氧代-2-硫代-1-咪唑烷基]-2-氟苯甲酰胺,N-desmethyl MDV 3100

     N-desMethyl EnzalutaMide (N-desmethyl MDV 3100) is the active metabolite of Enzalutamide, which is an oral androgen receptor inhibitor for treatment of castration-resistant prostate cancer.
  49. GC32408 LGD-4033 (Ligandrol)

    An Analytical Reference Standard
  50. GC32403 LGD-3303 LGD-3303是一种口服的非甾体选择性雄激素受体调节剂（SARM），与雄激素受体具有高亲和力（Ki=0.9nM）。
  51. GC32402 ORM-15341 ORM-15341 is a potent and full antagonist for human AR (hAR) with IC50 value of 38 nM and the inhibition constant (Ki) value of 8?nM.

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