GlpBio

5-HT Receptor

5-HT Receptor(5-羟色胺受体)

5-HT receptor (5-hydroxytryptamine receptors) is a group of GPCRs (G protein-coupled receptors) and LGICs (ligand-gated ion channels) found in the central and peripheral nervous systems.

5-HT Receptor 相关产品(419)

  • GC25434 structure
    GC25434Frovatriptan Succinate
    CAS: 158930-09-7

    Frovatriptan Succinate(SB 209509 Succinate,VML 251 Succinate) is the succinate salt form of frovatriptan, a synthetic triptan with serotonin (5-HT) receptor agonist activity especially for the 5-HT1B/1D receptors.

  • GC25563 structure
    GC25563Lasmiditan succinate
    CAS: 439239-92-6

    Lasmiditan succinate (COL-144, LY573144) is a novel, centrally acting, highly selective 5-HT(1F) receptor agonist (Ki=2.21 nM) without vasoconstrictor activity.

  • GC25569 structure
    GC25569Lerisetron
    CAS: 143257-98-1

    Lerisetron (F 0930, F 0930RS) is a 5-HT3 receptor antagonist with IC50 of 0.81μM.

  • GC25756 structure
    GC25756Pirenperone
    CAS: 75444-65-4

    Pirenperone (R-47456, R-50656), a quinazoline derivative, is a selective antagonist of SR-2A (5-HT2 serotonin receptor) when employed in low doses. Pirenperone behaves like a typical neuroleptic when used in higher doses (greater than 0.1 mg/kg).

  • GC25898 structure
    GC25898SB 200646
    CAS: 143797-63-1

    SB 200646 (SB 200646A) is a potent, selective and oral-active antagonist of 5-HT2B/2C over 5-HT2A receptor with 50 fold selectivity. The pKi for rat 5-HT2C receptor, rat 5-HT2B receptor and rat 5-HT2A receptor are 6.9, 7.5 and 5.2, respectively. SB 200646 has electrophysiological and anxiolytic properties in vivo.

  • GC26002 structure
    GC26002Trazodone
    CAS: 19794-93-5
    纯度: >98.00%

    Trazodone (AF-1161) is a 5-HT 2A/2C receptor antagonist that is used as an antidepressant for treating major depressive disorder and anxiety disorders.

  • GC30198 structure
    GC30198Dolasetron Mesylate hydrate
    CAS: 878143-33-0
    纯度: >99.00%

    A 5-HT 3 receptor antagonist

  • GC30206 structure
    GC30206Roluperidone (CYR-101)
    CAS: 359625-79-9
    纯度: >99.50%

    A dual antagonist of 5-HT 2A and σ 2 receptors

  • GC30273 structure
    GC30273Tedatioxetine hydrobromide (Lu AA 24530 hydrobromide)
    CAS: 960151-65-9
    纯度: >99.50%

    Tedatioxetine (Lu AA24530) hydrobromide 可作为 5-HT2A、5-HT2C、5-HT3 和 α；1A-肾上腺素受体拮抗剂，可作为 5-羟色胺和去甲肾上腺素 (NE) 的首选三重再摄取抑制剂 (TRI)。

  • GC30280 structure
    GC30280Chlorpromazine D6 hydrochloride
    CAS: 1228182-46-4
    纯度: >99.50%

    Chlorpromazine D6 hydrochloride是 Chlorpromazine 的氘代物，可被用于 NMR、GC-MS 或 LC-MS 分析中的内标品，用于定量分析。

  • GC30314 structure
    GC303145-HT4 antagonist 1
    CAS: 261766-73-8

    5-HT4antagonist1是一个5-HT4受体拮抗剂，其pKi值为9.6。

  • GC30352 structure
    GC30352Lintopride
    CAS: 107429-63-0

    Lintopride是5HT4拮抗剂，对5HT3有轻微拮抗作用。

  • GC30412 structure
    GC30412Dolasetron (MDL-73147)
    CAS: 115956-12-2
    纯度: >98.00%

    A 5-HT 3 receptor antagonist

  • GC30413 structure
    GC30413Dolasetron Mesylate (MDL-73147EF)
    CAS: 115956-13-3

    A 5-HT 3 receptor antagonist

  • GC30446 structure
    GC30446MHP 133
    CAS: 147340-43-0

    MHP133是一种多靶点抑制剂，可以抑制AChE的活性，KKi值为69μM;同时抑制毒蕈碱M1和M2受体，5HT4受体和咪唑I2受体。

  • GC30681 structure
    GC30681Revexepride
    CAS: 219984-49-3

    Revexepride是一种高度选择性的5-HT4receptor激动剂，也是潜在的CYP3A4enzyme诱导剂，可用于治疗胃食管返流疾病。

  • GC30762 structure
    GC30762Harmine (Telepathine)
    CAS: 442-51-3
    纯度: >99.50%

    A unique regulator of PPARγ expression

  • GC30787 structure
    GC30787Sertindole (Lu 23-174)
    CAS: 106516-24-9
    纯度: >99.50%

    An atypical antipsychotic

  • GC30796 structure
    GC30796Nelotanserin (APD125)
    CAS: 839713-36-9
    纯度: >99.50%

    Nelotanserin (APD125) 是一种有效的 5-HT2A 反向激动剂、中度有效的 5-HT2C 部分反向激动剂和弱 5-HT2B 反向激动剂，在 IP 积累试验中 IC50 分别为 1.7、79、791 nM。

  • GC30797 structure
    GC30797lumateperone Tosylate (ITI-007)
    CAS: 1187020-80-9
    纯度: >99.00%

    An atypical antipsychotic

  • GC30826 structure
    GC30826Temanogrel (APD791)
    CAS: 887936-68-7
    纯度: >98.50%

    Temanogrel (APD791) 是一种高度选择性的 5-HT2A 受体拮抗剂，Ki 为 4.9 nM。

  • GC30880 structure
    GC30880LP-211
    CAS: 1052147-86-0
    纯度: >99.50%

    LP-211是一种选择性的、可透过血脑屏障的5-HT 7 受体（K i =0.58nM）激动剂，选择性高于5-HT 1A 受体（K i =188nM）和D2受体（K i =142nM）。

  • GC30888 structure
    GC308888-OH-DPAT (8-Hydroxy-DPAT)
    CAS: 78950-78-4
    纯度: >95.00%

    8-OH-DPAT 是5-HT1A 激动剂， pIC50 值为 8.19 ，此外8-OH-DPAT对5-HT1B(pIC50 , 5.42)和5-HT (pIC50 <5)受体亲和力都很弱 。

  • GC30907 structure
    GC30907AVN-492
    CAS: 1220646-23-0
    纯度: >99.50%

    A 5-HT 6 receptor antagonist