Angiogenesis(血管生成)

Cat.No. 产品名称 Information

GC17263 Leukadherin 1 An allosteric activator of CD11b/CD18

GC14857 LFM-A13 A BTK inhibitor

GC19222 Lifitegrast

立他司特; SAR 1118; SHP-606

An inhibitor of the LFA-1/ICAM-1 interaction

GC90787 Lipid A4

一种分支离子化阳离子脂质类物质。

GC13227 LRGILS-NH2 LRGILS-NH2 是一种反向序列蛋白酶激活受体-2 (PAR-2)-失活的阴性对照，SLIGRL-NH2 是一种 PAR-2 激活肽。

GC47582 Lupulone

蛇床酮

A beta-acid

GC32724 LW6 (HIF-1α inhibitor)

HIF-1α inhibitor; LW8

LW6是一种缺氧诱导因子1(hypoxia inducing factor 1, HIF)抑制剂,通过降解HIF-1α有效抑制HIF-1α的积累,但不影响缺氧时HIF- 1a mRNA水平。

GC36500 LXW7 LXW7 是一种八聚二硫环肽，为整合素 αvβ3 的配体，能够有效、特异性地靶作用于内皮祖细胞 (EPCs) 和内皮细胞 (ECs)。在 ECs 细胞中，LXW7 可增强 VEGFR-2 的磷酸化和 ERK1/2 的活化。

GC40865 LYG-202 A synthetic flavonoid with anticancer and anti-angiogenic activities

GC32055 MK-0429 (L-000845704)

L-000845704

MK-0429 (L-000845704) (L-000845704) 是一种具有口服活性的、有效的、选择性的非肽类泛整合素拮抗剂，对于 α 的 IC50 值为 1.6 nM、2.8 nM、0.1 nM、0.7 nM、0.5 nM 和 12.2 nM ;vβ1, αvβ3, αvβ5, αvβ6, αvβ8 and α5β1, respectively.

GC19251 MK-8617 A HIF-PH1, -2, and -3 inhibitor

GC14319 ML 228

CID-46742353

A HIF pathway activator

GC13004 ML161

ML161

Reversible inhibitor of PAR1-mediated platelet activation

GC18608 MMP-2/MMP-9 Inhibitor II

Matrix Metalloproteinase-2/Matrix Metalloproteinase-9 Inhibitor II

A dual inhibitor of MMP-2 and MMP-9

GC18616 MMP-8 Inhibitor I

Matrix Metalloproteinase-8 Inhibitor I

A selective inhibitor of MMP-8

GC10048 MNS

3,4-亚甲二氧-beta-硝基苯乙烯,NSC 170724; 5-(2-Nitrovinyl)benzodioxole

An inhibitor of Src, Syk, and platelet aggregation

GC10046 Molidustat (BAY85-3934)

BAY 85-3934

A pan-HIF-PH inhibitor

GC36661 MT-802 MT-802 is a potent PROTAC that induces Bruton's tyrosine kinase (BTK) knockdown. MT-802 recruits BTK to the cereblon E3 ubiquitin ligase complex to trigger BTK ubiquitination and degradation via the proteasome. MT-802 has potential for treatment of C481S mutant chronic lymphocytic leukemia (CLL).

GC49686 N-desmethyl Regorafenib N-oxide

瑞戈非尼杂质14

An active metabolite of regorafenib

GC62255 N-piperidine Ibrutinib hydrochloride N-piperidine Ibrutinib hydrochloride, a reversible Ibrutinib derivative, is a potent BTK inhibitor with IC50s of 51.0 and 30.7 nM for WT BTK and C481S BTK, respectively.

GC44290 NAADP (sodium salt)

Nicotinic acid adenine dinucleotide phosphate

A secondary messenger that induces calcium mobilization

GC61109 Natalizumab

那他珠单抗

Natalizumab是一种重组的人源化单克隆抗体，与α4β1-整联蛋白(α4β1-integrin)结合并阻断其与血管细胞粘附分子1(VCAM-1)的相互作用。Natalizumab可用于复发缓解型多发性硬化症和克罗恩氏病的研究。Natalizumab也可阻止淋巴细胞进入中枢神经系统，从而防止急性脱髓鞘复发。

GC44358 Nebivolol O-β-D-Glucuronide An active metabolite of nebivolol

GC91360 NM-3 NM-3是一种合成异香豆素，可以抑制血管生成。

GC73434 NRX-0492 NRX-0492是一种口服有效的BTK降解剂。

GC44465 NSC 12

NSC 172285

An FGF inhibitor

GC44475 NVP-BEZ235 (hydrochloride)

Dactolisib

Dual inhibitor of PI3K and mTOR

GC69600 NX-2127 NX-2127 是一种口服有效的 BTK 抑制剂，可诱导细胞中突变的 BTKC481S 降解。NX-2127 抑制 BTKC481S 突变体 TMD8 细胞的增殖，比 Ibrutinib 更有效。NX-2127 催化 Ikaros (IKZF1) 和 Aiolos (IKZF3) 的降解，对应的作用浓度分别为 25 nM 和 54 nM。NX-2127 刺激 T 细胞活化并增加原代人 T 细胞中 IL-2 的产生。

GC49349 O-Desethyl Sildenafil

西地那非杂质C

A metabolite of sildenafil

GC16107 Obtustatin 整合素 α1β1 抑制剂

GC74342 Obtustatin triacetate Obtustatin triacetate是一种41个残基的非RGD解整合素。

GC17358 Octyl-α-ketoglutarate

α-KG octyl ester

A cell-permeable form of α-ketoglutarate

GC15199 OGT 2115 An inhibitor of heparanase

GC12821 Oltipraz

奥替普拉; RP 35972; NSC 347901

A Nrf2 and CAR activator

GC13219 ONO-4059

GS-4059 analog

A derivative of ONO-4059

GC69630 Orbofiban acetate Orbofiban acetate是一种口服活性血小板膜糖蛋白IIb/IIIa拮抗剂，抑制血小板聚集。

GC41625 Oroxylin A

千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

A flavonoid with diverse biological activities

GC36821 OSU-T315

OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).