GlpBio

BTK

BTK(布鲁顿酪氨酸激酶)

BTK (Bruton's tyrosine kinase) binds PIP3 and phosphorylates phospholipase C, plays a crucial role in B cell maturation as well as mast cell activation.

BTK 相关产品(71)

  • GC11230 structure
    GC11230RN486
    CAS: 1242156-23-5
    纯度: >99.50%

    A selective BTK inhibitor

  • GC11063 structure
    GC11063BMX-IN-1
    CAS: 1431525-23-3
    纯度: >98.50%

    A selective BMX and BTK inhibitor

  • GC11995 structure
    GC11995GDC-0834
    CAS: 1133432-50-4
    纯度: >99.00%

    GDC-0834 是 GDC-0834 的 S-对映异构体。

  • GC13219 structure
    GC13219ONO-4059
    CAS: 1351635-67-0
    纯度: >99.50%

    A derivative of ONO-4059

  • GC13365 structure
    GC13365CGI-1746
    CAS: 910232-84-7
    纯度: >98.00%

    A potent, selective BTK inhibitor

  • GC13439 structure
    GC13439CNX-774
    CAS: 1202759-32-7
    纯度: >99.00%

    A potent, selective, and irreversible BTK inhibitor

  • GC13562 structure
    GC13562AVL-292
    CAS: 1202757-89-8
    纯度: >98.00%

    A covalent BTK inhibitor

  • GC13812 structure
    GC13812PCI-32765 (Ibrutinib)
    CAS: 936563-96-1
    纯度: >99.50%

    PCI-32765 (Ibrutinib) 是一种不可逆的选择性布鲁顿氏酪氨酸激酶 (BTK) 抑制剂，可选择性靶向其激酶结构域并通过降低其磷酸化能力来调节 BTK 下游信号传导，在无细胞试验中 IC50 为 0.5 nM 。

  • GC14857 structure
    GC14857LFM-A13
    CAS: 244240-24-2
    纯度: >99.50%

    A BTK inhibitor

  • GC15453 structure
    GC15453ACP-196
    CAS: 1420477-60-6
    纯度: >99.50%

    A BTK inhibitor

  • GC19162 structure
    GC19162GDC-0853
    CAS: 1434048-34-6
    纯度: >99.50%

    A BTK inhibitor

  • GC19333 structure
    GC19333BTK IN-1
    CAS: 1270014-40-8
    纯度: >98.50%

    A BTK inhibitor

  • GC30155 structure
    GC30155PCI-33380
    CAS: 1022899-36-0

    PCI-33380是布鲁顿酪氨酸激酶(BTK)的不可逆抑制剂(荧光探针)。

  • GC31339 structure
    GC31339PRN1008
    CAS: 1575596-29-0
    纯度: >98.00%

    PRN1008 (Rilzabrutinib) is a reversible covalent, selective and oral active inhibitor of Bruton’s Tyrosine Kinase (BTK), with an IC50 of 1.3 nM.

  • GC31679 structure
    GC31679ARQ 531
    CAS: 2095393-15-8
    纯度: >99.00%

    Nemtabrutinib (ARQ 531, MK-1026) is an ATP-competitive tyrosine kinase inhibitor designed to target BTK with an IC50 of 0.85 nM. It also has a distinct kinase selectivity profile with strong inhibitory activity against several key oncogenic drivers from TEC, Trk and Src family kinases.

  • GC31713 structure
    GC31713BMS-986142
    CAS: 1643368-58-4
    纯度: >99.50%

    A BTK inhibitor

  • GC31760 structure
    GC31760BMS-935177
    CAS: 1231889-53-4
    纯度: >99.00%

    BMS-935177 is a potent, reversible Bruton's Tyrosine Kinase (BTK) inhibitor with an IC50 value of 2.8 nM and demonstrates good kinase selectivity. It is more potent against BTK than other kinase, including the other Tec family kinases (TEC, BMX, ITK, and TXK) over which the compound is between 5- and 67-fold selective.

  • GC32007 structure
    GC32007Btk inhibitor 2
    CAS: 1558036-85-3
    纯度: >99.50%

    Btk inhibitor 2 is a BTK inhibitor.

  • GC32844 structure
    GC32844BMS-986195
    CAS: 1912445-55-6
    纯度: >99.50%

    A covalent BTK inhibitor

  • GC33064 structure
    GC33064CG-806 (Luxeptinib)
    CAS: 1616428-23-9
    纯度: >99.00%

    CG-806 (Luxeptinib) (CG-806) 是一种具有口服活性、可逆、一流、非共价且有效的 pan-FLT3/pan-BTK 抑制剂。 CG-806 (Luxeptinib) 在急性髓性白血病细胞中诱导细胞周期停滞、凋亡或自噬。

  • GC33821 structure
    GC33821Tirabrutinib (ONO-4059)
    CAS: 1351636-18-4
    纯度: >99.50%

    A BTK inhibitor

  • GC34062 structure
    GC34062Evobrutinib (M2951)
    CAS: 1415823-73-2
    纯度: >98.00%

    Evobrutinib 作为一种口服、高选择性、共价的布鲁顿氏酪氨酸激酶抑制剂，具有良好的耐受性和有效性。

  • GC34069 structure
    GC34069(±)-Zanubrutinib ((±)-BGB-3111)
    CAS: 1633350-06-7
    纯度: >99.50%

    (±)-Zanubrutinib ((±)-BGB-3111) ((±)-BGB-3111) 是一种有效的、选择性的和口服的 Bruton's 酪氨酸激酶 (Btk) 抑制剂。

  • GC34075 structure
    GC34075Zanubrutinib (BGB-3111)
    CAS: 1691249-45-2
    纯度: >99.00%

    A potent and covalent BTK inhibitor