Autophagy
Autophagy(自噬)
Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.
Autophagy 相关产品(1140)
- GC30646Skatole(3-Methylindole)CAS: 83-34-1纯度: >99.50%
Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.
- GC30744Norepinephrine (Adrenor)CAS: 51-41-2纯度: >98.00%
(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
- GC30761α-Hydroxylinoleic acidCAS: 57818-44-7纯度: >98.00%
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation.
- GC30790Triflupromazine hydrochlorideCAS: 1098-60-8纯度: >99.50%
A phenothiazine with diverse biological activities
- GC30842Androsterone (5α-Androstan-3α-ol-17-one)CAS: 53-41-8纯度: >98.00% / >95.00%
Androsterone (5α-Androstan-3α-ol-17-one)是睾酮的一种代谢产物，可调节癫痫发作的易感性。
- GC30871Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)CAS: 28094-15-7纯度: >98.00% / >97.00%
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。
- GC30992Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)CAS: 110429-35-1
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.
- GC31317Sitagliptin (MK0431)CAS: 486460-32-6纯度: >99.50%
Sitagliptin (MK0431) 是一种口服、高选择性的二肽基肽酶-4（DPP-4）抑制剂，IC 50 为18nM。
- GC31386(-)-PX20606 trans isomer ((-)-PX-102 trans isomer)CAS: 1268244-88-7
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。
- GC31395PX20606 trans racemate (PX-102 trans racemate)CAS: 1268244-85-4纯度: >98.50%
PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。
- GC31586Monacolin J (Antibiotic MB 530A)CAS: 79952-42-4
Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，可抑制 HMG-CoA 还原酶的活性。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC30565 | BAR502 | 1612191-86-2 | >98.00% | |
A dual agonist of GP-BAR1 and FXR | ||||
| GC30608 | Ipsalazide | 82101-17-5 | - | |
Ipsalazide是一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的5-氨基水杨酸和无毒载体分子。 | ||||
| GC30609 | p38 MAPK-IN-2 | 635725-16-5 | - | |
p38MAPK-IN-2是一种p38kinase的抑制剂。 | ||||
| GC30646 | Skatole(3-Methylindole) | 83-34-1 | >99.50% | |
Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect. | ||||
| GC30676 | MAPK13-IN-1 | 229002-10-2 | >98.00% | |
MPAK13-IN-1是MAPK13(p38δ)的一个抑制剂，其IC50值为620nM。 | ||||
| GC30744 | Norepinephrine (Adrenor) | 51-41-2 | >98.00% | |
(-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively. | ||||
| GC30751 | FAAH-IN-1 | 1242441-47-9 | - | |
FAAH-IN-1是脂肪酸酰胺水解酶(FAAH)抑制剂，对大鼠和人FAAH的IC50值分别为145nM和650nM。 | ||||
| GC30761 | α-Hydroxylinoleic acid | 57818-44-7 | >98.00% | |
ABTL0812 (α-Hydroxylinoleic acid, LP-10218, SCLN-0812) inhibits Akt/mTOR axis by inducing the overexpression of TRIB3 and activating autophagy in lung squamous carcinoma cell lines. ABTL0812 also induces AMPK activation and ROS accumulation. | ||||
| GC30785 | 4E2RCat | 432499-63-3 | >98.00% | |
4E2RCat是eIF4E-eIF4G相互作用的抑制剂，IC50值为13.5μM。 | ||||
| GC30787 | Sertindole (Lu 23-174) | 106516-24-9 | >99.50% | |
An atypical antipsychotic | ||||
| GC30790 | Triflupromazine hydrochloride | 1098-60-8 | >99.50% | |
A phenothiazine with diverse biological activities | ||||
| GC30842 | Androsterone (5α-Androstan-3α-ol-17-one) | 53-41-8 | >98.00% / >95.00% | |
Androsterone (5α-Androstan-3α-ol-17-one)是睾酮的一种代谢产物，可调节癫痫发作的易感性。 | ||||
| GC30871 | Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride) | 28094-15-7 | >98.00% / >97.00% | |
Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。 | ||||
| GC30884 | LX2343 | 333745-53-2 | >99.50% | |
An inhibitor of BACE1 and PI3K | ||||
| GC30990 | Calcineurin substrate | 113873-67-9 | - | |
A synthetic peptide substrate | ||||
| GC30992 | Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate) | 110429-35-1 | - | |
Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type. | ||||
| GC31058 | FR 167653 free base | 158876-65-4 | - | |
FR-167653是一种选择性的p38MAPK抑制剂。 | ||||
| GC31170 | Calmodulin-Dependent Protein Kinase II 290-309 | 115044-69-4 | - | |
A CaMKII inhibitor | ||||
| GC31239 | SA72 | 934809-60-6 | - | |
SA72是高度选择性的脂肪酸酰胺水解酶(FAAH)抑制剂。 | ||||
| GC31317 | Sitagliptin (MK0431) | 486460-32-6 | >99.50% | |
Sitagliptin (MK0431) 是一种口服、高选择性的二肽基肽酶-4（DPP-4）抑制剂，IC 50 为18nM。 | ||||
| GC31386 | (-)-PX20606 trans isomer ((-)-PX-102 trans isomer) | 1268244-88-7 | - | |
(-)-PX20606 trans isomer ((-)-PX-102 trans isomer) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 18 和 29 nM。 | ||||
| GC31395 | PX20606 trans racemate (PX-102 trans racemate) | 1268244-85-4 | >98.50% | |
PX20606 trans racemate (PX-102 trans racemate) (PX-102 trans racemate) 是一种 FXR 激动剂，在 FRET 和 M1H 试验中对 FXR 的 EC50 分别为 32 和 34 nM。 | ||||
| GC31586 | Monacolin J (Antibiotic MB 530A) | 79952-42-4 | - | |
Monacolin J (Antibiotic MB 530A) 是一种胆固醇生物合成抑制剂，可抑制 HMG-CoA 还原酶的活性。 | ||||
| GC31665 | (R)-BPO-27 | 1415390-47-4 | >99.50% | |
(R)-BPO-27是有效的CFTR抑制剂，IC50值为4nM。 | ||||