Autophagy(自噬)

Cat.No. 产品名称 Information

GC33464 Oxyresveratrol (trans-Oxyresveratrol)

氧化白藜芦醇; trans-Oxyresveratrol

A resveratrol analog

GC33008 p38 MAPK-IN-1 p38MAPK-IN-1是p38MAPK新型高效选择性抑制剂,IC50值68nM。

GC30609 p38 MAPK-IN-2 p38MAPK-IN-2是一种p38kinase的抑制剂。

GC31988 p38α inhibitor 1

p38αinhibitor1是p38α的抑制剂，来自专利WO2008076265A1。

GC30158 p38-α MAPK-IN-1

p38-α MAPK-IN-1 is an inhibitor of p38-α, with IC50 value of 2300 nM in EFC displacement assay, and 5500 nM in HTRF assay.

GC11993 PAC-1

Procaspase activating compound 1

An in vitro procaspase-3 activator

GC12511 Paclitaxel (Taxol)

紫杉醇

紫杉醇是从短叶红豆杉的树皮和针叶中提取出来的三环二萜化合物。

GN10498 Paeonol

丹皮酚

A phenol with diverse biological activities

GC69650 Paeonol-d3 Paeonol-d3 是氘代的 Paeonol 。

GC14304 Palovarotene

4-[(1E)-2-[5,6,7,8-四氢-5,5,8,8-四甲基-3-(1H-吡唑-1-基甲基)-2-萘基]乙烯基]苯甲酸,R 667; Ro 3300074

A RARγ agonist

GC15814 Pamapimod (R-1503, Ro4402257)

Ro4402257; R1503

An orally bioavailable inhibitor of p38α MAP kinase

GC12257 Panobinostat (LBH589)

帕比司他; LBH589; NVP-LBH589

A pan-HDAC inhibitor

GC12718 Pantoprazole

泮托拉唑; BY1023; SKF96022

A proton pump inhibitor

GC36847 Pantoprazole sodium

泮托拉唑钠; BY1023 sodium; SKF96022 sodium

A proton pump inhibitor

GC36848 Pantoprazole sodium hydrate

泮托拉唑钠水合物; BY1023 sodium hydrate; SKF96022 sodium hydrate

A proton pump inhibitor

GC36855 Paris saponin VII

重楼皂苷 VII; Chonglou Saponin VII

Chonglou Saponin VII (Dioscinin, Polyphyllin-VII, Paris saponin-VII), a kind of steroidal saponins from Chonglou (Rhizoma Paridis Chonglou), inhibits EMT and reduces the invasion of ovarian cancer cells via the GSK-3β/β-catenin signaling pathway.

GC17229 Paroxetine HCl

盐酸帕罗西汀; BRL29060 hydrochloride; BRL29060A

A selective serotonin reuptake inhibitor

GC30992 Paroxetine hydrochloride hemihydrate (BRL29060 hydrochloride hemihydrate)

盐酸帕罗西汀半水合物; BRL29060 hydrochloride hemihydrate; BRL29060A hemihydrate

Paroxetine HCl (BRL-29060A, FG-7051) is an antidepressant drug of the SSRI type.

GC71661 Paroxetine-d4 hydrochloride Paroxetine-d4 hydrochloride是氘标记的盐酸帕罗西汀。

GN10357 Parthenolide

小白菊内酯; (-)-Parthenolide

Parthenolide是一种NF-κB抑制剂，对Eca109、KYSE-510、SiHa和MCF-7细胞48h的IC₅₀值分别约为10.3、13.3、8.42和9.54µM。

GC16327 Pazopanib (GW-786034)

帕唑帕尼; GW786034

A multi-kinase inhibitor

GC12730 Pazopanib Hydrochloride

盐酸帕唑帕尼; GW786034 (Hydrochloride)

A multi-kinase inhibitor

GC72911 Pazopanib-13C,d3 hydrochloride

GW786034-13C,d3 hydrochloride

Pazopanib-13C,d3 hydrochloride是氘和13C标记的盐酸帕唑帕尼。

GC12205 PD 146176

NSC168807

PD 146176 是一种有效的选择性网织红细胞 15-LOX-1 抑制剂。

GC17737 PD 169316

4-[4-(4-氟苯基)-2-(4-硝基苯基)-1H-咪唑-5-基]吡啶

A specific p38 MAPK inhibitor

GC19279 PD-166866 A potent inhibitor of FGFR1

GC10397 PD0325901

N-[(2R)-2,3-二羟基丙氧基]-3,4-二氟-2-[(2-氟-4-碘苯)氨基]苯甲酰胺,PD0325901,PD-0325901,PD 0325901,PD325901,PD 325901,PD-325901

PD0325901是一种具口服活性、选择性和非ATP竞争性的丝裂原活化蛋白激酶激酶（MEK）抑制剂，IC₅₀值为0.33nM。

GC11015 PD168393 An irreversible EGFR kinase inhibitor

GC12819 PD98059

2-(2-氨基-3-甲氧基苯基)-4H-1-苯并吡喃-4-酮

D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。

GN10084 Peiminine

贝母素乙,Vertieinon

An alkaloid with diverse biological activities

GC11610 Pemetrexed

培美曲塞二钠盐; LY231514 disodium

An antifolate with anticancer activity

GC17694 Pemetrexed disodium hemipenta hydrate

培美曲塞二钠水合物; LY231514 disodium hemipenta hydrate

Pemetrexed disodium hemipenta hydrate 是一种新型抗叶酸剂，LY231514 的五谷氨酸的 Ki 值分别为 1.3、7.2 和 65 nM，用于抑制胸苷酸合酶 (TS)、二氢叶酸还原酶 (DHFR) 和甘氨酰胺核糖核苷酸甲酰转移酶 (GARFT)。

GC10458 Penfluridol

五氟利多; R-16341

A typical antipsychotic

GC36868 Pennogenin 3-O-beta-chacotrioside

偏诺皂苷元-3-O-Α-L-吡喃鼠李糖-(1→4)[Α-L-吡喃鼠李糖基](1→2)-Β-D-葡萄糖苷

Pennogenin 3-O-beta-chacotrioside, an active component isolated from Paris polyphylla, modulates autophagy via increasing the expressions of autophagy-related proteins LC3 and Beclin-1, and posesses anti-colorectal cancer activity.

GC40685 Pentoxifylline

NSC 637086, Oxpentifylline

Pentoxifylline is a methylxanthine derivative.

GC11974 Pepstatin A

抑肽素; Pepstatin A

胃抑素Pepstatin A是由放线菌类产生的一种特异性的、具有口服活性的天冬氨酸蛋白酶 (aspartic proteases) 抑制剂,能够抑制 hemoglobin-pepsin、hemoglobin-proctase、casein-pepsin、casein-proctase、casein-acid protease 和 hemoglobin-acid protease 的活性,IC50 值分别为 4.5 nM、6.2 nM、150 nM、290 nM、520 nM 和 260 nM；Pepstatin A可抑制 HIV protease 的活性.Pepstatin A (0-120 µM) 抑制了受体活化因子NF-κB配体(RANKL)-诱导的破骨细胞分化。