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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC14129 Nilotinib(AMN-107)

    尼洛替尼; AMN107

     Nilotinib(AMN-107)（尼洛替尼）是一种选择性口服酪氨酸激酶抑制剂，可抑制天然Bcr-Abl（WT p210）和突变型Bcr-Abl（E281K、E292K、F317L、M351T和F486S）的自磷酸化，IC50值分别为20、42、31、38、29和41nM。
  3. GC16587 Nimodipine

    尼莫地平; BAY-e 9736

     Nimodipine是一种1,4-二氢吡啶类L型钙离子通道拮抗剂，主要用于治疗动脉瘤性蛛网膜下腔出血（aSAH），预防脑血管痉挛。
  4. GC11618 Nitazoxanide

    硝唑尼特; NTZ; NSC 697855

     Nitazoxanide是一种噻唑烷类抗原虫和抗病毒药物，对抑制Giardia lamblia滋养体增殖的IC50为2.4μM。Nitazoxanide常被用于感染性疾病的研究，并可能在治疗病毒性胃肠炎和寄生虫感染等疾病中具有潜在应用价值。
  5. GC16999 Nitrendipine

    尼群地平; BAY-E-5009

     An L-type calcium channel blocker
  6. GC34009 Nitroprusside disodium dihydrate (Sodium nitroprusside dihydrate)

    硝普钠二水合物; Sodium nitroprusside dihydrate; Sodium Nitroferricyanide(III) Dihydrate

     Sodium Nitroprusside Dihydrate is a potent vasodilator working through releasing NO spontaneously in blood.
  7. GC11365 Nitroxoline

    硝羟喹啉; 8-Hydroxy-5-nitroquinoline; 5-Nitro-8-quinolinol

     An 8-hydroxyquinoline with diverse biological activities
  8. GC39411 NL-1 The mitochondrial mitoNEET ligand NL-1 is a mitoNEET inhibitor, which induces a concentration-dependent decrease in cell viability with an IC50 of 47.35 μM and 56.26 μM in REH and REH/Ara-C cells respectively. The docking studies using liver mitochondrial suspensions show the IC50 of NL-1 binding for [3H]-rosiglitazone is 0.9 μM and the Ki for NL-1 site 1 and site 2 was 4.78 and 2.77, respectively.
  9. GN10325 Nobiletin

    川陈皮素

     A flavonoid with diverse biological activities
  10. GC14075 Nocodazole

    诺考达唑

     Nocodazole是一种抗有丝分裂药物，是一种快速可逆的微管聚合抑制剂，在无细胞试验中抑制Abl，Abl（E255K）和Abl（T315I），IC50值分别为0.21μM，0.53μM和0.64μM。
  11. GC50113 Noradrenaline bitartrate

    L-去甲肾上腺素酒石酸氢盐(酯),Levarterenol tartrate; L-Noradrenaline tartrate

     Norepinephrine (Levarterenol; L-Noradrenaline) tartrate 是一种有效的肾上腺素能受体 (AR) 激动剂。
  12. GC10976 Noradrenaline bitartrate monohydrate

    酒石酸去甲肾上腺素; Levarterenol bitartrate monohydrate; L-Noradrenaline bitartrate monohydrate

     An adrenoceptor agonist
  13. GC18089 Nordihydroguaiaretic acid

    去甲二氢愈创木酸; NDGA

     A non-selective LO inhibitor
  14. GC30744 Norepinephrine (Adrenor)

    去甲肾上腺素; Levarterenol; L-Noradrenaline

    (-)-Norepinephrine (Arterenol, Levarterenol, L-Noradrenaline) is a natural neurotransmitter and hormone. It is an agonist of adrenergic receptors with Ki values of 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively.
  15. GC36758 Norepinephrine hydrochloride

    去甲肾上腺素盐酸盐; Levarterenol hydrochloride; L-Noradrenaline hydrochloride

    A racemic mixture of of L-norepinephrine and D-norepinephrine
  16. GC64076 Nortriptyline

    去甲替林,Desmethylamitriptyline; Desitriptilina

     Nortriptyline hydrochloride (Desitriptyline, ELF-101, EN-7048, Desmethylamitriptyline) is the hydrochloride salt form of nortriptyline, a tricyclic antidepressant agent used for short-term treatment of various forms of depression.
  17. GC11989 Nortriptyline (hydrochloride)

    盐酸去甲替林; Desmethylamitriptyline hydrochloride; Desitriptilina hydrochloride

     A tricyclic antidepressant
  18. GC32821 Noscapine ((S,R)-Noscapine)

    那可汀

     Noscapine是一种口服止咳药,主要通过其σ受体激动剂活性调节,且Noscapine具有抗癌活性。
  19. GC39023 Notoginsenoside Fc

    三七皂苷 FC

     Notoginsenoside Fc 是从三七叶中分离得到的一种原卟啉二醇 (PPD-) 型皂苷，可有效抵消血小板聚集。Notoginsenoside Fc 可以通过促进自噬促进糖尿病大鼠血管损伤后的内皮细胞再生。
  20. GC16486 Novobiocin Sodium

    新生霉素钠,Albamycin sodium; Cathomycin sodium

     An inhibitor of DNA gyrase
  21. GC12424 NS 1643 An activator of ERG1 and ERG2
  22. GC44464 NSC 109555

    DDUG, NCI C04808

     An inhibitor of Chk2
  23. GC34924 NSC 185058 An inhibitor of ATG4B
  24. GC10470 Nutlin-3a chiral

    Nutlin-3a;Nutlin 3a

     Nutlin-3a 手性是 Nutlin-3 的活性异构体，是鼠类双微体 2 (MDM2) 拮抗剂，IC50 值为 0.09μM。
  25. GC12963 NVP-AEW541

    AEW541

     An IGF-1R inhibitor
  26. GC16145 NVP-BGT226

    NVP-BGT226 maleate

     A dual PI3K and mTOR inhibitor
  27. GC11569 Obatoclax mesylate (GX15-070)

    Obatoclax甲磺酸盐,GX15-070 Mesylate

     An antagonist of pro-survival Bcl-2 proteins
  28. GC14158 Obeticholic Acid

    奥贝胆酸; INT-747; 6-ECDCA; 6-Ethylchenodeoxycholic acid

     Obeticholic Acid（奥贝胆酸；INT-747；6-ECDCA；6-Ethylchenodeoxycholic acid）是一种有效的，选择性的和口服活性的法尼醇X受体（FXR ）激动剂，EC50为99nM。
  29. GC70528 Obeticholic acid-d5 Obeticholic acid-d5是氘标记的奥贝胆酸。
  30. GC64358 Olacaftor

    VX-440

     Olacaftor (VX-440) 是囊性纤维化跨膜电导调节因子 (CFTR) 的调节剂，来自专利US9782408。
  31. GC12495 Olanzapine

    奥氮平; LY170053

     Olanzapine是一种单胺拮抗剂。
  32. GC61809 Olanzapine D3

    奥氮平 D3; LY170053-d3

     OlanzapineD3(LY170053D3)是Olanzapine的氘代物。Olanzapine是一种选择性单胺能拮抗剂，高亲和力结合5-羟色胺H1，5HT2A/2C，5HT3，5HT6(Ki分别为7、4、11、57和5nM)，多巴胺D1-4(Ki=11-31nM)，毒蕈碱M1-5(Ki=1.9-25nM)和肾上腺素α1受体(Ki=19nM)。Olanzapine是一种非典型的抗精神病剂。
  33. GC17580 Olaparib (AZD2281, Ku-0059436)

    奥拉帕尼; AZD2281; KU0059436

     Olaparib (AZD2281, Ku-0059436) 是一种有效的选择性 PARP 抑制剂，特异性靶向 PARP1 和 PARP2（IC 50 分别 = 5 nM 和 1 nM）。
  34. GN10184 Oleanolic acid

    齐墩果酸; Oleanic acid; Caryophyllin

     Oleanolic acid齐墩果酸是一种天然的五环三萜，长期以来一直被用作治疗肝炎的有效药物。齐墩果酸对多种癌症也有抗肿瘤作用。
  35. GC49815 Oleuropein aglycone

    3,4-DHPEA-EA

     A polyphenol with diverse biological activities
  36. GC13166 Omeprazole

    奥美拉挫; H 16868

     An irreversible inhibitor of the gastric proton pump
  37. GC36806 Omeprazole D3

    奥美拉挫 D3; H 16868-d3

     An internal standard for the quantification of omeprazole
  38. GC61155 Omeprazole sodium

    奥美拉唑钠,H 16868 sodium

     An irreversible inhibitor of the gastric proton pump
  39. GC64070 Omeprazole-d3-1

    奥美拉唑-D3,H 16868-d3-1

     An internal standard for the quantification of omeprazole
  40. GN10332 Onjisaponin B

    远志皂苷B

     A triterpenoid saponin with neuroprotective activity
  41. GC15447 Oprozomib (ONX-0912)

    ONX-0912,ONX0912,ONX 0912,PR 047,Oprozomib

     An orally available proteasome inhibitor
  42. GC39260 OR-1855

    (R)-6-(4-氨基苯基)-4,5-二氢-5-甲基-3(2H)-哒嗪酮

     OR-1855 是 Levosimendan 的活性代谢产物，对人体肌层收缩力有影响。Levosimendan 是一种钙敏感性药物，用于治疗急性失代偿性充血性心力衰竭。
  43. GN10732 Oroxin B

    木蝴蝶苷B

     Oroxin B (OB) 是从中草药 Oroxylum indicum (L.) Vent 中分离得到的黄酮类化合物。Oroxin B (OB) 具有明显的抑制作用，通过上调 PTEN、下调 PTEN 诱导肝癌细胞早期凋亡而不是晚期凋亡COX-2、VEGF、PI3K 和 p-AKT.Oroxin B (OB) 在恶性淋巴瘤细胞中选择性诱导肿瘤抑制性 ER 应激。
  44. GC41625 Oroxylin A

    千层纸素A; Baicalein 6-methyl ether; 6-Methoxybaicalein

     A flavonoid with diverse biological activities
  45. GC14071 OSI-027

    反式-4-[4-氨基-5-(7-甲氧基-1H-吲哚-2-基)咪唑并[5,1-F][1,2,4]三嗪-7-基]环己烷羧酸,ASP7486

     Dual mTORC1/mTORC2 inhibitor
  46. GC15742 OSU-03012 (AR-12)

    2-氨基-N-[4-[5-(2-菲基)-3-(三氟甲基)-1H-吡唑-1-基]苯基]乙酰胺

     An anti-cancer celecoxib analog
  47. GC36821 OSU-T315

    OSU-T315 (ILK-IN-1) is a small Integrin-linked kinase (ILK) inhibitor with an IC50 of 0.6 μM, inhibiting PI3K/AKT signaling by dephosphorylation of AKT-Ser473 and other ILK targets (GSK-3β and myosin light chain).
  48. GC10579 Ouabain Octahydrate

    乌本(箭毒)苷,哇巴因,Acocantherine; G-Strophanthin

     Ouabain Octahydrate是一种Na+/K+-ATPase抑制剂，能够用于研究充血性心力衰竭。
  49. GC17716 Oxaliplatin

    奥沙利铂

    奥沙利铂（Oxaliplatin）是一种用于治疗癌症的细胞毒性化疗药物。
  50. GC30871 Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)

    6-羟基多巴胺盐酸盐; 6-Hydroxydopamine hydrochloride; 6-OHDA hydrochloride

     Oxidopamine hydrochloride (6-Hydroxydopamine hydrochloride)（6-OHDA）是神经递质多巴胺的拮抗剂。
  51. GC33446 Oxyphenisatin acetate

    双醋酚丁

     Oxyphenisatinacetate是oxyphenisatin的前体药物，过去常用作泻药。

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