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Home >> Signaling Pathways >> Ubiquitination/ Proteasome >> Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Products for  Autophagy

  1. Cat.No. 产品名称 Information
  2. GC62626 ICCB-19 hydrochloride ICCB-19 hydrochloride is an inhibitor of TNFRSF1A Associated Via Death Domain (TRADD) with IC50 of 1.12 μM and 2.01 μM for protecting Velcade-induced apoptosis in Jurkat cells and protecting RDA in MEFs, respectively. ICCB-19 indirectly inhibits Receptor-interacting serine/threonine-protein kinase 1 (RIPK1). ICCB-19 effectively induces autophagy.
  3. GC14969 Idarubicin HCl

    盐酸伊达比星; 4-Demethoxydaunorubicin hydrochloride

     Antitumor antibiotic used in treatment of leukemia
  4. GC62465 Idelalisib D5

    CAL-101 D5; GS-1101 D5

     Idelalisib D5 (CAL-101 D) 是 Idelalisib 的一种氘代化合物。Idelalisib 是一种口服有效的高选择性 p110δ 抑制剂。
  5. GC19411 IITZ-01 IITZ-01 是一种有效的溶酶体自噬抑制剂，具有单剂抗肿瘤活性，对 PI3Kγ 的 IC50 为 2.62 μM。
  6. GC10314 Imatinib (STI571)

    伊马替尼; STI571; CGP-57148B

     伊马替尼 (STI571) (STI571) 是一种口服生物可利用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL、v-Abl、PDGFR 和 c-kit 激酶活性。伊马替尼 (STI571) (STI571) 通过在 ATP 结合位点附近结合而起作用，将其锁定在封闭或自我抑制的构象中，从而半竞争性地抑制蛋白质的酶活性。伊马替尼 (STI571) 也是 SARS-CoV 和 MERS-CoV 的抑制剂。
  7. GC60930 Imatinib D4

    [2H4]-伊马替尼,STI571 D4; CGP-57148B D4

     ImatinibD4(STI571D4)是Imatinib(STI571)的氘代物。Imatinib是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制BCR/ABL，v-Abl，PDGFR，c-kit激酶活性。
  8. GC39612 Imatinib D8

    伊马替尼D8,STI571-d8; CGP-57148B-d8

     Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。
  9. GC11759 Imatinib Mesylate (STI571)

    甲磺酸伊马替尼; STI571 Mesylate; CGP-57148B Mesylate

     Imatinib Mesylate (STI571)是一种口服生物有效的多靶点抑制剂，对Bcr-Abl，c-Kit和PDGFR的IC50分别为0.6μM，0.1μM 和0.1μM。
  10. GC16407 Imiquimod

    咪喹莫特; R 837

    A TLR7 agonist
  11. GC10712 Imiquimod hydrochloride

    盐酸咪喹莫特; R 837 hydrochloride

    A TLR7 agonist
  12. GC12645 Imiquimod maleate

    马来酸咪喹莫特; R 837 maleate

    A TLR7 agonist
  13. GC49670 Indium (III) thiosemicarbazone 5b An anticancer agent
  14. GC17556 Indomethacin

    吲哚美辛; Indometacin

     Indomethacin(吲哚美辛)是一种有效的口服活性 COX1/2 抑制剂,COX-1 和 COX-2 的IC50 值分别为 18 nM 和 26 nM。
  15. GC60935 Indomethacin sodium hydrate

    吲哚美辛钠盐三水合物; Indometacin sodium hydrate

     A non-selective COX inhibitor
  16. GC40227 Indomethacin-d4

    吲哚美辛-D4; Indometacin-d4

     An internal standard for the quantification of indomethacin
  17. GC61565 Indophagolin

    5-溴-N-(4-氯-3-(三氟甲基)苯基)-1-(环丙烷羰基)吲哚啉-6-磺酰胺

     Indophagolin, a potent indoline-containing autophagy inhibitor with IC50 of 140 nM, antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively, also has a strong antagonistic effect on serotonin receptor 5-HT6 with IC50 of 1.0 μM.
  18. GC10969 INK 128 (MLN0128)

    沙帕色替; INK-128; MLN0128; TAK-228

     Inhibitor of TORC1/2
  19. GC32742 INT-767 INT-767是法尼醇X受体/TGR5双激动剂，平均EC50分别为30和630nM。
  20. GC16105 Iohexol

    碘海醇

     A contrast reagent
  21. GC11229 IOWH-032

    3-(3,5-二溴-4-羟基苯基)-N-(4-苯氧基苄基)-1,2,4-恶二唑-5-甲酰胺

     A modulator of CFTR
  22. GC30608 Ipsalazide

    伊普柳氮

    Ipsalazide是一种新的柳氮磺吡啶类似物，旨在释放胃肠道中的5-氨基水杨酸和无毒载体分子。
  23. GC11473 Irinotecan

    伊立替康; (+)-Irinotecan; CPT-11

     Irinotecan是一种拓扑异构酶抑制剂，主要用于治疗结直肠癌。Irinotecan可通过与拓扑异构酶 I-DNA 复合物结合，阻止 DNA 链的再连接，并导致 DNA 双链断裂和细胞死亡 。
  24. GC11048 Irinotecan HCl Trihydrate

    盐酸伊立替康三水合物; (+)-Irinotecan hydrochloride trihydrate; CPT-11 hydrochloride trihydrate

     A potent inhibitor of DNA topoisomerase I
  25. GC36329 Irinotecan hydrochloride

    伊立替康盐酸盐; (+)-Irinotecan hydrochloride; CPT-11 hydrochloride

     A potent inhibitor of DNA topoisomerase I
  26. GN10666 Isoalantolactone

    异土木香内酯; (+)-Isoalantolactone; Isohelenin

     A sesquiterpene lactone with diverse biological activities
  27. GC13795 Isobavachalcone

    补骨脂乙素; Corylifolinin; Isobacachalcone

     A chalcone and flavonoid with diverse biological activities
  28. GC39109 Isodeoxyelephantopin

    异去氧苦地胆苦素

     Isodeoxyelephantopin 是一种倍半萜烯内酯，可从Elephantopus scaber 中分离得到。Isodeoxyelephantopin 可诱导活性氧的生成，抑制NF-κB 的激活。Isodeoxyelephantopin 还能调节LncRNA 的表达，有抗乳腺癌的作用。
  29. GN10088 Isoliquiritigenin

    异甘草素; GU17; ISL; Isoliquiritigen; SJ000286237

     A flavonoid with diverse biological activities
  30. GC12017 Isoniazid

    异烟肼; INH; Isonicotinic acid hydrazide; Isonicotinic hydrazide

     An inhibitor of mycolic acid synthesis
  31. GC64098 Isoniazid-d4

    异烟肼-D4,INH-d4; Isonicotinic acid hydrazide-d4; Isonicotinic hydrazide-d4

     Isoniazid-d4 (INH-d4) 是 Isoniazid 的氘代物。Isoniazid (INH) 是一种前药，必须被细菌过氧化氢酶 KatG 激活。Isoniazid 对快速分裂的分枝杆菌具有杀菌作用，并具有抗菌活性。
  32. GC36339 Isorhapontigenin

    异丹叶大黄素

     Isorhapontigenin (ISOR), isolated from Belamcanda chinensis, is a derivative of stilbene. Isorhapontigenin possessed potent antioxidative activity. Isorhapontigenin suppresses interleukin-1β-induced inflammation and cartilage matrix damage in rat chondrocytes.
  33. GC15826 Isosorbide

    异山梨酯; D-Isosorbide; Dianhydro-D-glucitol

     A dianhydrohexitol
  34. GC36346 Isosorbide mononitrate

    单硝酸异山梨酯; Isosorbide-5-mononitrate

     A nitric oxide donor with cardioprotective activity
  35. GC15382 Isotretinoin

    异维A酸; 13-cis-Retinoic acid

     A retinoid
  36. GC43922 Isovaleryl-L-carnitine (chloride)

    L-异戊酰基肉碱

     An acylcarnitine
  37. GC47470 Isovaleryl-L-carnitine-d3 (chloride)

    CAR 5:0-d3, C5:0 Carnitine-d3, L-Carnitine isovaleryl ester-d3, L-Isovalerylcarnitine-d3

     A neuropeptide with diverse biological activities
  38. GC10447 Isradipine (Dynacirc)

    伊拉地平,PN 200-110

     An L-type calcium channel blocker
  39. GC15462 ISRIB (trans-isomer)

    ISRIB(TRANS-ISOMER)抑制剂

     ISRIB (trans-isomer)是一种选择性抑制整合应激反应（ISR）通路的小分子化合物。ISRIB (trans-isomer)是PERK的一种高度选择性抑制剂，IC50为5nM。
  40. GC11056 Itraconazole

    伊曲康唑 ; R51211

     An antifungal agent and hedgehog pathway inhibitor
  41. GC74091 Itraconazole-d9

    R51211-d9

     Itraconazole-d9是氘标记的伊曲康唑。
  42. GC32209 ITX5061 ITX5061是一个II型p38MAPK抑制剂，也是清道夫受体B1(SR-B1)的拮抗剂。
  43. GC14797 IU1

    Usp14 inhibitor

     IU1是一种细胞可渗透的、可逆的选择性蛋白酶体抑制剂，对USP14的 IC50 为 4.7μM。
  44. GC10296 Ivacaftor (VX-770)

    依伐卡托; VX-770

     A CFTR potentiator
  45. GC12489 Ivacaftor benzenesulfonate

    VX-770 benzenesulfonate;VX 770 benzenesulfonate;VX770 benzenesulfonate;Kalydeco benzenesulfonate

     A CFTR potentiator
  46. GC13316 Ivacaftor hydrate

    VX-770 hydrate;VX 770 hydrate;VX770 hydrate;Kalydeco hydrate

     A CFTR potentiator
  47. GC12339 Ivermectin

    伊维菌素; MK-933

     A mixture of ivermectin B1a and ivermectin B1b
  48. GC36356 Ixazomib citrate

    枸橼酸艾沙佐米; MLN9708

     Ixazomib citrate (MLN9708, Ninlaro) is a prodrug of Ixazomib (MLN2238), which is a selective, orally bioavailable inhibitor of 20S proteasome that inhibits the chymotrypsin-like proteolytic (β5) site with IC50 of 3.4 nM and Ki of 0.93 nM, respectively. Ixazomib (MLN2238) also inhibits caspase-like (β1) and trypsin-like (β2) proteolytic sites with IC50 of 31 nM and 3500 nM, respectively.
  49. GC65331 IZCZ-3 IZCZ-3 是有效的 c-MYC 转录抑制剂，具有抗肿瘤活性。
  50. GC10133 JNJ-42165279

    N-(4-氯-3-吡啶基)-4-[(2,2-二氟-1,3-苯并二恶茂-5-基)甲基]-1-哌嗪甲酰胺

     An irreversible FAAH inhibitor
  51. GC32690 JPH203 (KYT-0353)

    KYT-0353

     JPH203 (KYT-0353) 是一种选择性 L 型氨基酸转运蛋白 1 抑制剂，显着抑制 HT-29 YD-38 和白血病细胞的亮氨酸摄取和细胞生长，IC50 值分别为 0.06 μM 和 4.1 μM 。

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