GlpBio

Autophagy

Autophagy(自噬)

Autophagy is a catabolic process which degrades and recycles long-lived proteins and cytoplasmic organelles through lysosome. It plays an important role in growth regulation and maintenance of homeostasis.

Autophagy 相关产品(1140)

  • GC12793 structure
    GC12793RITA (NSC 652287)
    CAS: 213261-59-7
    纯度: >99.00%

    RITA (NSC 652287)是一种三环噻吩衍生物，可结合p53dN（K d =1.5nM）并阻断p53-HDM-2相互作用，抑制p53泛素化。

  • GC12801 structure
    GC12801Rasagiline Mesylate
    CAS: 161735-79-1
    纯度: >99.50%

    An inhibitor of MAO-B

  • GC12804 structure
    GC12804KN-93 Phosphate
    CAS: 1913269-12-1
    纯度: >99.50%

    KN-93 Phosphate是一种有效的、细胞膜通透性的、选择性Ca 2+ /钙调蛋白依赖性蛋白激酶II（CaMKII）抑制剂，IC 50 值为0.37μM。

  • GC12805 structure
    GC12805Procainamide HCl
    CAS: 614-39-1
    纯度: >98.00%

    An Analytical Reference Standard

  • GC12819 structure
    GC12819PD98059
    CAS: 167869-21-8
    纯度: >98.00%

    D98059是一种有效的选择性MEK抑制剂，IC50为2 μM。

  • GC12828 structure
    GC12828Daunorubicin
    CAS: 20830-81-3

    Daunorubicin是一种天然来源的蒽环类抗生素，通过嵌入DNA双链并抑制拓扑异构酶Ⅱ活性，阻断DNA复制与转录，从而诱导肿瘤细胞凋亡。

  • GC12830 structure
    GC12830Stavudine (d4T)
    CAS: 3056-17-5
    纯度: >99.50%

    An inhibitor of HIV reverse transcriptase

  • GC12843 structure
    GC12843MEK162 (ARRY-162, ARRY-438162)
    CAS: 606143-89-9
    纯度: >99.50%

    A MEK1/2 inhibitor

  • GC12846 structure
    GC12846Elaiophylin
    CAS: 37318-06-2

    A macrodiolide antibiotic

  • GC12918 structure
    GC12918TPEN
    CAS: 16858-02-9
    纯度: >99.00% / >97.00%

    TPEN是一种可穿透细胞的多齿重金属螯合剂，能够高亲和力地结合锌离子，并且对Mg 2+ 和Ca 2+ 具有较低的亲和力。

  • GC12920 structure
    GC12920Pregnenolone
    CAS: 145-13-1
    纯度: >98.00%

    A natural steroid hormone

  • GC12926 structure
    GC12926VX-745
    CAS: 209410-46-8
    纯度: >99.00% / >98.00%

    A p38α MAPK inhibitor

  • GC12942 structure
    GC12942DAPT (GSI-IX)
    CAS: 208255-80-5
    纯度: >98.00%

    DAPT (GSI-IX) 是一种具有口服活性的 γ-分泌酶抑制剂，对人原代神经元培养物中产生的总淀粉样蛋白-β (Aβ) 和 Aβ42 的 IC50 分别为 115 nM 和 200 nM。

  • GC12963 structure
    GC12963NVP-AEW541
    CAS: 475489-16-8
    纯度: >98.50%

    An IGF-1R inhibitor

  • GC12993 structure
    GC12993Vancomycin hydrochloride
    CAS: 1404-93-9
    纯度: >99.50% / >98.00%

    A glycopeptide antibiotic

  • GC13001 structure
    GC13001SB 203580 hydrochloride
    CAS: 869185-85-3
    纯度: >98.00%

    A water soluble p38 MAPK inhibitor

  • GC13022 structure
    GC13022Esomeprazole Magnesium trihydrate
    CAS: 217087-09-7

    An H + /K + -ATPase inhibitor

  • GC13023 structure
    GC13023KC02
    CAS: 1646795-60-9

    Structural analog and inactive form of KC01

  • GC13029 structure
    GC13029AZD2014
    CAS: 1009298-59-2
    纯度: >98.50%

    A potent dual mTORC1/2 inhibitor

  • GC13035 structure
    GC13035Bay 11-7821
    CAS: 19542-67-7
    纯度: >99.50% / >95.00%

    Bay 11-7821是一种IκBα磷酸化和NF-κB抑制剂，选择性且不可逆地抑制TNF-α诱导的IκB-α磷酸化（IC 50 值约为10μM），并减少NF-κB和粘附分子的表达。Bay 11-7821抑制泛素特异性蛋白酶USP7和USP21，IC 50 分别为0.19、0.96μM。

  • GC13037 structure
    GC13037CX-4945 (Silmitasertib)
    CAS: 1009820-21-6
    纯度: >99.50%

    CX-4945 (Silmitasertib)是一种有效的具口服活性的酪蛋白激酶2（CK2）抑制剂，对CK2α的IC 50 值为1nM。

  • GC13055 structure
    GC13055Mocetinostat (MGCD0103, MG0103)
    CAS: 726169-73-9
    纯度: >99.00%

    An orally available HDAC inhibitor

  • GC13063 structure
    GC13063N-Benzylpalmitamide
    CAS: 74058-71-2
    纯度: >98.00%

    A long-chain fatty acid amide

  • GC13065 structure
    GC13065Chelerythrine Chloride
    CAS: 3895-92-9
    纯度: >98.50% / >98.00%

    Chelerythrine Chloride是一种强效且可渗透细胞的蛋白激酶C（protein kinase C, PKC）抑制剂，IC 50 值为660nM。