TGF-β / Smad Signaling
TGF-β / Smad Signaling(TGF-β / Smad 信号转导)
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that regulates proliferation, migration, differentiation, and survival of many different cell types. Deletion or mutation of different members of the TGF-β family have been shown to cause vascular remodeling defect and absence of mural cell formation, leading to embryonic lethality or severe vascular disorders. TGF-β induces smooth muscle differentiation via Notch or SMAD2 and SMAD3 signaling in ES cells or in a neural crest stem cell line. TGF-β binds to TGF-βRI and to induce phosphorylation of SMAD2/3, thereby inhibiting proliferation, tube formation, and migration of endothelial cells (ECs).
TGF-β is a pluripotent cytokine with dual tumour-suppressive and tumour-promoting effects. TGF-β induces the epithelial-to-mesenchymal transition (EMT) leading to increased cell plasticity at the onset of cancer cell invasion and metastasis.
TGF-β / Smad Signaling 相关产品(360)
- GC39398LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA)纯度: >98.00%
LSKL, Inhibitor of Thrombospondin TSP-1是一种来源于潜伏相关蛋白（LAP）-TGFβ的四肽，可竞争性结合抑制TGF-β1。
- GC39612Imatinib D8CAS: 1092942-82-9
Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。
- GC40080Bosutinib-d8CAS: 2733145-45-2纯度: >99.00%
An internal standard for the quantification of bosutinib
- GC40197Pirfenidone-d5CAS: 1020719-62-3纯度: >99.00%
An internal standard for the quantification of pirfenidone
- GC40928Trimethylamine N-oxideCAS: 1184-78-7纯度: >95.00%
A metabolite of choline, phosphatidylcholine, and L-carnitine
- GC44655PKCε Inhibitor PeptideCAS: 182683-50-7纯度: >98.00%
PKCε Inhibitor Peptide，也称为 εV1-2，是一种蛋白激酶 C ε (PKCε) 衍生肽，作为选择性 PKCε 抑制剂，抑制 PKCε 的易位 。
- GC45828Ponatinib-d8CAS: 1562993-37-6纯度: >99.00%
An internal standard for the quantification of ponatinib
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39398 | LSKL, Inhibitor of Thrombospondin (TSP-1) (TFA) | - | >98.00% | |
LSKL, Inhibitor of Thrombospondin TSP-1是一种来源于潜伏相关蛋白（LAP）-TGFβ的四肽，可竞争性结合抑制TGF-β1。 | ||||
| GC39612 | Imatinib D8 | 1092942-82-9 | - | |
Imatinib D8 (STI571 D8) 是 Imatinib (STI571) 的氘代物。Imatinib 是一种口服生物可用的酪氨酸激酶抑制剂，可选择性抑制 BCR/ABL，v-Abl，PDGFR，c-kit 激酶活性。 | ||||
| GC40080 | Bosutinib-d8 | 2733145-45-2 | >99.00% | |
An internal standard for the quantification of bosutinib | ||||
| GC40197 | Pirfenidone-d5 | 1020719-62-3 | >99.00% | |
An internal standard for the quantification of pirfenidone | ||||
| GC40770 | L-erythro Sphingosine (d18:1) | 6036-75-5 | >98.00% | |
A bioactive sphingolipid | ||||
| GC40928 | Trimethylamine N-oxide | 1184-78-7 | >95.00% | |
A metabolite of choline, phosphatidylcholine, and L-carnitine | ||||
| GC41737 | (S)-Glycyl-H-1152 (hydrochloride) | 913844-45-8 | >98.00% | |
A ROCK inhibitor | ||||
| GC41863 | 10,11-dehydro Curvularin | 21178-57-4 | >98.00% | |
A natural mycotoxin | ||||
| GC42747 | Afuresertib (hydrochloride) | 1047645-82-8 | >98.00% | |
A pan-Akt inhibitor | ||||
| GC43105 | C8 Ceramide (d18:1.8:0) | 74713-59-0 | >98.00% | |
A cell-permeable ceramide analog | ||||
| GC43184 | CAY10622 | 1038549-25-5 | >98.00% | |
A ROCK1 and ROCK2 inhibitor | ||||
| GC43286 | CMPD101 | 865608-11-3 | >98.50% | |
CMPD101是一种高效、高选择性且具有膜通透性的小分子G蛋白偶联受体激酶2（GRK2）和GRK3抑制剂，其对GRK2和GRK3的IC 50 值分别为18nM和5.4nM。 | ||||
| GC43993 | K252b | 99570-78-2 | >98.00% | |
A cell-impermeable kinase inhibitor | ||||
| GC44094 | LX7101 (hydrochloride) | 2319882-48-7 | >98.00% | |
A LIMK and ROCK inhibitor | ||||
| GC44303 | N-Acetylpuromycin | 22852-13-7 | >98.00% | |
A non-ribotoxic form of puromycin | ||||
| GC44655 | PKCε Inhibitor Peptide | 182683-50-7 | >98.00% | |
PKCε Inhibitor Peptide，也称为 εV1-2，是一种蛋白激酶 C ε (PKCε) 衍生肽，作为选择性 PKCε 抑制剂，抑制 PKCε 的易位 。 | ||||
| GC44729 | Prostratin | 60857-08-1 | >98.00% | |
An HIV re-activator | ||||
| GC44903 | SMAD3 Inhibitor, SIS3 | 1009104-85-1 | >98.00% | |
An inhibitor of TGF-β signaling | ||||
| GC45414 | CRT0066854 | 1438881-19-6 | >99.00% | |
A PKCι and PKCζ inhibitor | ||||
| GC45828 | Ponatinib-d8 | 1562993-37-6 | >99.00% | |
An internal standard for the quantification of ponatinib | ||||
| GC48345 | Lyso-Monosialoganglioside GM2 (ammonium salt) | - | >98.00% | |
A sphingolipid | ||||
| GC49269 | Myr-ZIP | - | >95.00% | |
A PKMζ inhibitor | ||||
| GC49334 | Chroman 1 (hydrochloride hydrate) | - | >98.00% | |
A ROCK2 inhibitor | ||||
| GC50043 | SR 3677 dihydrochloride | 1781628-88-3 | - | |
A ROCK1 and ROCK2 inhibitor | ||||