Hedgehog
Hh (Hedgehog) signalling is a evolutionarily conserved pathway that is critical for embryonic development, tissue and organ morphogenesis. Mammalian Hh protein ligands include Sonic Hh, Desert Hh and Indian Hh. Dysfunctions of Hh singalling lead to developmental abnormalities and cancer.
Hedgehog 相关产品(43)
- GC43809Hedgehog Antagonist VIIICAS: 330796-24-2纯度: >98.00%
An inhibitor of hedgehog pathway signaling
- GC44855RU-SKI 43 (hydrochloride)CAS: 1782573-67-4纯度: >98.50%
An inhibitor of hedgehog acyltransferase
- GC47474Itraconazole-d5CAS: 1217510-38-7纯度: >99.00%
An internal standard for the quantification of itraconazole
- GC48062RU-SKI 201 (hydrochloride)CAS: 2320262-09-5纯度: >95.00%
A neuropeptide with diverse biological activities
- GC4965119-alkyne CholesterolCAS: 2058319-71-2纯度: >95.00%
An alkyne derivative of cholesterol for click chemistry
- GC663903-epi-Vitamin D3CAS: 57651-82-8
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4) 是维生素 D3 类似物，是一种 Hedgehog pathway 抑制剂，在U87MG 细胞中测定的 IC50 为 39.2 μM。
- GC728381-Methyladenosine-d3 hydrochloride纯度: 不显示
1-Methyladenosine-d3 hydrochloride是氘的氯盐形式，标记为1-甲基腺苷。
- GC91424S1PL-IN-31CAS: 1538574-95-6纯度: >98.00%
S1PL-IN-31是一种抑制神经酰胺-1-磷酸（S1P）裂解酶的抑制剂（IC50 = 210 nM）。它也是平滑蛋白受体（Smo）的拮抗剂（IC50 = 440 nM）。
| 货号 | 产品名称 | CAS号 | 纯度 | 结构 |
|---|---|---|---|---|
| GC39359 | Ciliobrevin D | 1370554-01-0 | >98.00% | |
Ciliobrevin D是一种动力蛋白ATP酶活性抑制剂，可阻止马达蛋白的动力循环活动。 | ||||
| GC43346 | Cyclopamine-KAAD | 306387-90-6 | >96.00% | |
A potent inhibitor of hedgehog signaling | ||||
| GC43809 | Hedgehog Antagonist VIII | 330796-24-2 | >98.00% | |
An inhibitor of hedgehog pathway signaling | ||||
| GC44321 | Nat-20(S)-yne | 1397692-46-4 | >90.00% | |
Nat-20(S)-OHC with a terminal alkyne group | ||||
| GC44458 | N-Palmitoyl-L-Aspartate | 1782-17-8 | >98.00% | |
A natural N-acylaspartate | ||||
| GC44855 | RU-SKI 43 (hydrochloride) | 1782573-67-4 | >98.50% | |
An inhibitor of hedgehog acyltransferase | ||||
| GC45090 | Triparanol | 78-41-1 | >98.00% | |
An inhibitor of DHCR24 | ||||
| GC47435 | HPI-1 (hydrate) | - | >95.00% | |
A Hedgehog pathway inhibitor | ||||
| GC47474 | Itraconazole-d5 | 1217510-38-7 | >99.00% | |
An internal standard for the quantification of itraconazole | ||||
| GC47570 | Lipoxygenin | 2247911-68-6 | >98.00% | |
An inhibitor of 5-LO | ||||
| GC48062 | RU-SKI 201 (hydrochloride) | 2320262-09-5 | >95.00% | |
A neuropeptide with diverse biological activities | ||||
| GC49651 | 19-alkyne Cholesterol | 2058319-71-2 | >95.00% | |
An alkyne derivative of cholesterol for click chemistry | ||||
| GC64134 | Hh-Ag1.5 | 612542-14-0 | >99.00% | |
Hh-Ag1.5 (SAg1.5) 是一种有效的 Hedgehog (Hh) 激动剂，EC50 为 1 nM。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。 | ||||
| GC66390 | 3-epi-Vitamin D3 | 57651-82-8 | - | |
3-epi-Vitamin D3 (Epicholecalciferol) (Compound 4) 是维生素 D3 类似物，是一种 Hedgehog pathway 抑制剂，在U87MG 细胞中测定的 IC50 为 39.2 μM。 | ||||
| GC72838 | 1-Methyladenosine-d3 hydrochloride | - | 不显示 | |
1-Methyladenosine-d3 hydrochloride是氘的氯盐形式，标记为1-甲基腺苷。 | ||||
| GC73310 | SMO-IN-2 | 1822355-27-0 | >98.00% | |
SMO-IN-2（化合物1）是一种有效的SMO （smoothened）抑制剂，对hedgehog （Hh）信号通路的IC50值为123.4 nM。 | ||||
| GC73776 | DS-1-38 | - | >99.00% | |
DS-1-38是一种EYA1拮抗剂，可阻断Sonic Hedgehog （SHH）信号。 | ||||
| GC74091 | Itraconazole-d9 | 1309272-50-1 | >97.00% | |
Itraconazole-d9是氘标记的伊曲康唑。 | ||||
| GC91424 | S1PL-IN-31 | 1538574-95-6 | >98.00% | |
S1PL-IN-31是一种抑制神经酰胺-1-磷酸（S1P）裂解酶的抑制剂（IC50 = 210 nM）。它也是平滑蛋白受体（Smo）的拮抗剂（IC50 = 440 nM）。 | ||||